Diabetes is associated with depression and anxiety symptoms. The current investigation was designed to explore the effect of melatonin on depressive like-behaviours, oxidative stress, levels AGE, RAGE S100B in streptozotocin-induced diabetic rats. animals were divided into four groups: Normoglycemic; Normoglycemic + melatonin; diabetic; (10 mg/kg, for 4 weeks). malondialdehyde (MDA), reduced glutathione (GSH), measured like-behaviours assessed by forced swimming elevated plus maze tests,...

Depression and anxiety are common mental health disorders affecting thoughts, behaviors, emotions. This study aimed to investigate the effect of angiotensin II type I receptor blocker (AT1RB), valsartan, on menopause-induced depression anxiety-like elucidate possible mechanisms action by measuring levels nod-like protein 3 (NLRP3), interleukin-1beta (IL-1β), brain-derived neurotrophic factor (BDNF), oxidative stress in brain tissue. Thirty-two Wistar albino female rats were randomly divided...

Multiple organ failure, including acute lung injury, is a common complication of intestinal ischemia and reperfusion (I/R) injury contributes to its high mortality rate. Activated polymorphonuclear neutrophils reactive oxygen species contribute the caused by I/R. Mineralocorticoid receptor antagonist spironolactone has protective effect against I/R in animal models retina, kidney, heart, brain. The aim present study investigate aldosterone blocker on induced I/R.Wistar albino rats were...

Purpose: Angiotensin converting enzyme inhibitors (ACEI) and type I angiotensin receptor blockers (ARB) have been shown to exert significant effects on bone tissue via a local renin-angiotensin-aldosterone system (RAS). The aim of our study was delineate their influences fracture healing process. Methods: Sixty adult male Wistar Albino rats were divided into three groups. After undergoing surgical femoral fixation, the ACEI group received 10 mg/kg Enalapril, ARB Losartan Control did not...

The aim of this study was to evaluate the effect obesity on renal functions and possible relationship between TGF-beta1 in hypertensive patients. Seventy newly diagnosed, patients (male/female 36/34, aged 45.0 +/- 8.0 years) 30 17/13, 41.8 7.7 normotensive controls were included. Patients both groups analyzed for serum levels glucose, creatinine, uric acid, lipids, TGF-beta1. A 24-hour urine sample also obtained; creatinine clearance rate urinary albumin excretion (UEA) investigated....

Serious functional and structural alterations of gastrointestinal tract are observed in failure blood supply, leading to dismotility. Activation opioid receptors provides cardioprotective effect against ischemia-reperfusion (I/R) injury. The aim the present study was determine whether or not remifentanil could reduce I/R injury small intestine.Male Wistar Albino rats were subjected mesenteric ischemia (30 min) followed by reperfusion (3h). Four groups designed: sham control; alone;...

Several studies have shown that low estrogen levels can lead to an increase in the incidence of depression and anxiety during menopause. The hippocampus prefrontal cortex are parts brain involved depressive- anxiety-like behaviors. Recent revealed metformin has neuroprotective effects mainly due its antioxidant properties. aim present study was examine therapeutic potential behavior as well oxidative stress ovariectomized rats. Young female Wistar Albino rats were distributed into four...

BACKGROUND: One of the important risk factors for dementia is chronic cerebral hypoperfusion (CCH) especially in patients with cerebrovascular disease.OBJECTIVES: In present study, using rat model bilateral common carotid artery occlusion, possible protective effects ethyl pyruvate (EP) have been explored terms memory impairment, oxidative stress, and levels caspase-3, Na-K ATPase, IL-1β.METHODS: Rats were treated EP (50 mg/kg, i.p) 4 weeks.Cognitive function was evaluated by Morris Water...

It is still not clear whether mitral valve prolapse (MVP) a risk factor for ischemic stroke. The aim of this study was to evaluate uncomplicated MVP silent cerebral events. Fifty-two patients with and 46 control subjects without were included in the study. All evaluated infarct (SCI) magnetic resonance imaging. Five (9.6%) who had but no other factors events SCI. results suggest that SCI, should receive anti-platelet-aggregating drugs.

Objective: The aim of this study is to put forward the association between helicobacter pylori infection and elevated low density lipoprotein cholesterol among patients who were admitted family medicine at Baskent University Adana Teaching Medical Research Center. Methods: records 463 referred esophagogastroduodenoscopy analysed in retrospective study. Results rapid urease test (CLO) or histopathologic examination gastric biopsy recorded. lipid profile was investigated. Results: Mean age...

Intraperitoneal adhesions are fibrous bands that form between tissues and organs in the abdominal cavity, which can result from body's healing process after surgery, leading to pain, bowel obstruction, infertility severe cases. Magnesium (Mg), known for its anti-inflammatory anticoagulant properties, has been hypothesized influence adhesion formation.

Aim: Postoperative cognitive dysfunction (POCD) is usually seen in the aged patients postoperative
 period. In present study, we aimed to investigate effects of melatonin on and synaptic
 oxidative stress POCD model constructed by abdominal surgery rats.
 Material Methods: Twenty months old male Wistar rats were randomly allocated into control
 group, treated-control group treated-surgery group. The novel
 object recognition test (NORT) was used assess postoperative...

Amaç: Diabetes mellitus (DM) kronik hiperglisemi ile karakterize metabolik bir hastalıktır. Bu çalışmanın amacı, melatoninin DM’li sıçanlarda iskelet kası ve kalp üzerindeki etkilerini değerlendirmektir. Gereç Yöntemler: 36 erkek Wistar albino rat kontrol grubu, + melatonin Diyabet grubu olarak 4 gruba ayrıldı. Melatonin (10 mg / kg, ip) tedavisi dört hafta süreyle uygulandı. Malondialdehit (MDA) seviyeleri indirgenmiş glutatyon (GSH) Nrf2 tiyoredoksin (TRX) değerlendirildi. Bulgular:...

Serious functional and structural alterations of gastrointestinal tract are observed in failure blood supply, leading to dismotility. Activation opioid receptors provides cardioprotective effect against ischemia-reperfusion (I/R) injury. The aim the present study was determine whether or not remifentanil could reduce I/R injury small intestine.Male Wistar Albino rats were subjected mesenteric ischemia (30min) followed by reperfusion (3h). Four groups designed: sham control; alone;...

Amaç: Oksidatif stresin diyabetik komplikasyonların gelişiminde çok önemli rol oynadığı yaygın

Amaç: Bu çalışma çevresel zenginleştirmenin (EE) kronik serebral hipoperfüzyonla (KSH) oluşturulan vasküler demans modelinde depresyon benzeri davranış, korteks ve hipokampüsde beyin kaynaklı nörotrofik faktör (BDNF), kaspaz-1 IL-1β seviyeleri üzerine etkisini incelemek için tasarlanmıştır.Daha önceki çalışmalar EE'nin KSH oksidatif stres inhibisyonu endojen nörokoruyucu faktörlerin artırılmasını içeren yararlı etkilere sahip olduğunu göstermişlerdir

Amaç: Glukagon benzeri peptit-1 (GLP-1), enteroendokrin L hücrelerinden salgılanan önemli bir inkretin hormondur. GLP-1 analogları, diyabet ve obezite tedavisi için kullanılmaktadır. Ovaryan hormonların kardiyovasküler fonksiyonların düzenlenmesinde etkili rol oynadığı iyi bilinmektedir. Postmenopozal kadınlarda hastalık insidansı artar. Bu çalışmanın amacı, yumurtalıkları alınmış sıçanlarda GLP- 1 analoğu olan liraglutid uygulanmasının kardiyak fonksiyonlar kalp dokusu oksidatif stres...

Aim: Menopause is defined as the depletion of ovarian follicular reserve followed by cessation menstrual cycles. It has been
 reported that gonadal steroid hormones play an important role in bladder function women. Changes urine pattern including
 overactive bladder, stress incontinence and recurrent urinary tract infections occur a result menopause. 1,1-dimethylbiguanide
 hydrochloride, metformin, (MET) oral anti-diabetic drug used to reduce hepatic glucose production...