Doxorubicin is a widely used agent in the treatment of cancer, but cardiotoxicity associated with this drug limits its potential for use. The cardioprotective effects dapagliflozin, an antidiabetic drug, have to counteract cardiotoxic effect doxorubicin therapy. In our study, we aimed investigate protective dapagliflozin from possible doxorubicin-induced cardiotoxicity.

With the increasing incidence of cancer among adult population, radiotherapy (RT) is frequently used as a critical component in treatment various types. Due to nature ionizing radiation, damage usually occurs within tissues anatomical neighborhood with primary tumor localization. Dapagliflozin (DAPA), originally developed an oral anti-diabetic medication, has been shown have potent cardioprotective effects DAPA-HF trial. The DAPA against RT induced cardiac cellular were investigated this...

Rhabdomyolysis (RM) can lead to life-threatening myoglobinuric acute kidney injury (AKI). Despite various treatment modalities for AKI, their effectiveness remains limited. Dexpanthenol (DEX) is an antioxidant, anti-inflammatory, and anti-apoptotic agent with demonstrated protective effects on tissues. The current study aimed investigate the genetic mechanisms of DEX in AKI due glycerol-induced RM. Thirty-two female Wistar Albino rats weighing between 250-300 g were allocated into four...

Background and Objective Periodontitis, a chronic inflammatory disease caused by oral bacterial infection, is considered to be risk factor for systemic diseases including diabetes mellitus, pneumonia, hyperlipidemia atherosclerosis. The aim of this study was evaluate the effectiveness melatonin against periodontal inflammation‐induced multiple organ injury in rats. Material Methods Eighteen female Wistar albino rats were randomly divided into three groups six each: control;...

In this study, we tested the effects of L-carnitine (LC) on radiation-induced ileal mucosal damage.Thirty Wistar albino rats were divided into five groups. The control group received physiological saline intraperitoneally (i.p.). Radiation-1 and radiation-2 groups whole-body X-irradiation 8.3 Gy as a single dose. These sacrificed at 6th hour 4th day after irradiation, respectively. + LC same dose irradiation plus daily 200 mg/kg LC. was applied one before for four days irradiation.The levels...

This study aimed to explore whether PARP-1 regulatory pathway mediated X irradiation induced cell cycle arrest and apoptosis or not. In this regard, colonic mucosal injury caused by whole-body X-irradiation through PARP-1, caspase 3 p53 were evaluated in experimental rat models. Eighteen Wistar albino rats divided into three groups. Two radiation groups received 8.3 Gy dose of as a single the control group physiological saline intraperitoneally. Radiation sacrificed after 6 h 4 days...

Poly(ADP-ribosyl)ation is a posttranslational protein modification carried out by family of enzymes referred to as poly(ADP-ribose) polymerases (PARPs). It has been proposed that the broad nuclear distribution PARPs may allow them modulate gene expression in addition their more accepted role DNA repair mediators. The poly(ADP-ribosyl)ation during oogenesis and folliculogenesis unknown. Here we found when 3- 4-wk-old mice were injected with 5-amninoisoquinolinone, water soluble inhibitor...

Purpose: Angiotensin converting enzyme inhibitors (ACEI) and type I angiotensin receptor blockers (ARB) have been shown to exert significant effects on bone tissue via a local renin-angiotensin-aldosterone system (RAS). The aim of our study was delineate their influences fracture healing process. Methods: Sixty adult male Wistar Albino rats were divided into three groups. After undergoing surgical femoral fixation, the ACEI group received 10 mg/kg Enalapril, ARB Losartan Control did not...

Background and Objectives: Ocular alkaline burn is a clinical emergency that can cause permanent vision loss due to limbal stem cell deficiency corneal neovascularization (CNV). Although the basic pathogenetic mechanisms are considered be acute oxidative stress triggered by inflammation, underlying intracellular have not been clearly elucidated. The aim of this study was investigate role endoplasmic reticulum (ER) on inflammation neovascularization, effect ER inhibitor salubrinal (SLB), as...

Methidathion (MD) is one of the most widely used organophosphate insecticides (OPIs) for public health programmes and agricultural purposes. However it causes side effects such as liver disorders. We examined ameliorating a combination vitamins E C against MD induced toxicity in rats. was given orally with single dose 8 mg/kg body weight at 0 h. Vitamin vitamin were injected 30 min after treatment doses 150 i.m. 200 i.p., respectively. Liver tissue samples taken 24 h administration. In...

This experiment was designed to investigate the lipid peroxidation and histological effects of chronic fluorosis on first second generation rat lung tissues. Sixteen, virgin, female Wistar rats were mated with eight males (2:1) for approximately 12 h obtain first-generation rats. Pregnant divided into two experimental groups (control fluoride supplemented). The pregnant in fluoride-supplemented group exposed 30 mg/L sodium (NaF) commercial drinking water containing 0.07 NaF throughout...

Structured Abstract Objects To investigate the effects of curcumin (CUR) and melatonin (MEL) on new bone formation following rapid maxillary expansion (RME) in rats. Setting Sample Population For this study, 24 12‐week‐old adult male Wistar albino rats from Animal Laboratory at Adnan Menderes University, Faculty Medicine, were used. Materials Methods The randomly divided into 3 groups (n = 8 each): only (OE), plus MEL CUR (CUR). given to during study period. After sacrifice animals,...

This study aimed to investigate the histopathological effects of thyroidectomy on both immature and adult rat testes.Male albino Wistar rats, 4 weeks old weighing between 45 55 g, were used for this study. The experimental groups as follows: 2-week control group (group I); II); 4-week III); IV); 6-week V), VI). included sham-operated untreated rats. In II, IV VI, total was performed under ether anesthesia in all rats at age. killed 2nd, 4th 6th weeks, respectively, following thyroidectomy....

The aim of the current study was to investigate whether agmatine (AGM) has a protective effect against cisplatin-induced nephrotoxicity.Thirty-two rats were randomly divided into four groups: (1) Saline (control); (2) Cisplatin (CDDP; 7.5 mg/kg intraperitoneally); (3) Agmatine (AGM; 10 (4) plus (CDDP + AGM). given before and two consecutive days after cisplatin injection. All animals underwent renal scintigraphy with 99mTc-DMSA. levels serum creatinine, cystatin C, blood urea nitrogen (BUN)...

This study was designed to investigate the effects of Dexpanthenol (Dxp) on liver and pancreas histology cytokine levels in streptozotocine (STZ)-induced diabetic rats. Twenty-four Wistar albino male rats were divided into four groups: control, Dxp, STZ-induced (STZ) treatment with (STZ-Dxp) groups. Experimental diabetes induced by single dose STZ (50 mg/kg) intraperitoneally (i.p.). After administration STZ, STZ-Dxp group began receive a 300 mg/kg/day i.p. Dxp for 6 weeks. Liver tissues...

Aim: The aim of this study was to investigate the effects shilajit on new bone formation following rapid maxillary expansion (RME) in a rat model using biochemical, histological, and immunohistochemical techniques.Material Method: rats (12-week-old, 24 male Wistar albino) were randomly divided into 3 groups (n=8 each): no (NE), only (OE), plus (Shilajit). Shilajit given during 5 day 12 retention period. After sacrificing animals, examinations performed.Results: Superoxide dismutase,...

Amaç: Bu çalışmanın amacı Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi’nde son 10 yıl içinde yayınlanan çalışmaları bibliyometrik yönden analiz edip dergide geliştirmesi gereken yönleri belirlemek ve derginin etki faktörünün arttırılması için öneri sunabilmektir. Gereç yöntemler: fakültesi Dergisi’nin kamuya açık dijital arşivi, elektronik veri tabanından tarandı. 2009-2018 yılları arasında yayınlanmış özgün araştırma, olgu sunumu derleme türündeki çalışmalar değerlendirmeye alındı....

Abstract Background: As in the rest of world, distance education methods have been introduced higher our country. The aim study is to evaluate satisfaction learning management system. Methods: was designed as a cross-sectional with mixed research design. 467 students stated their opinions for questionnaire (n: 467). Results: In evaluation scale total scores, mean calculated 17.72 ± 5.49 (min: 5, max: 25). Between preclinical term and clinical term, t-test performed independent groups, there...

Objective This study aims to evaluate the effect of ellagic acid (EA) by measuring levels alveolar bone resorption and inflammatory oxidative stress markers in periodontal tissues serum on repair process related experimental periodontitis rats. Methodology Forty Wistar rats were divided into four groups as follows: Group 1=healthy control (n=10); 2=EA (15 mg/kg)(n=10); 3=periodontitis 4=periodontitis+EA mg/kg) (n=10). The model was established ligating bilateral mandibular first molars for...