A5032634428- Birth, Development, and Health
- Paraoxonase enzyme and polymorphisms
- Pregnancy and preeclampsia studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Ischemia and Reperfusion
- Growth Hormone and Insulin-like Growth Factors
- Eicosanoids and Hypertension Pharmacology
- Sepsis Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
- Renal function and acid-base balance
- Pancreatitis Pathology and Treatment
- Spondyloarthritis Studies and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Advanced Glycation End Products research
- Lipoproteins and Cardiovascular Health
- Obstructive Sleep Apnea Research
- Reproductive System and Pregnancy
- Pituitary Gland Disorders and Treatments
- Sperm and Testicular Function
- Spinal Cord Injury Research
- Antioxidant Activity and Oxidative Stress
- Liver Disease Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- biodegradable polymer synthesis and properties
- Diabetes, Cardiovascular Risks, and Lipoproteins
University of Ottawa
2023-2024
Bülent Ecevit University
2009-2022
Laboratoire de Biochimie
2004-2006
Ministry of Health
1995
The aim of this study was to compare the anti-inflammatory response methylprednisolone and alpha2-agonist dexmedetomidine in spinal cord injury (SCI).Twenty-four male adult Wistar albino rats, weight 200-250 g, were included study. rats divided into four groups as follows: control group (n: 6) received only laminectomy; SCI with trauma alone; SCI+methylprednisolone 30 mg/kg methylprednisolone, followed by a maintenance dose 5.4 mg/kg/h; SCI+dexmedetomidine 10 microg/kg treatment...
Head trauma is one of the most important clinical issues that not only can be fatal and disabling, requiring long-term treatment care, but also cause heavy financial burden. Formation or distribution free oxygen radicals should decreased to enable fixing poor neurological outcomes prevent neuronal damage secondary ischemia after trauma. Coenzyme Q₁₀ (CoQ₁₀), a component mitochondrial electron transport chain, strong antioxidant plays role in membrane stabilization. In this study, CoQ₁₀ head...
Background: Preeclampsia is characterized by hypertension and proteinuria that begins in the second half of pregnancy. Endothelial dysfunction trophoblastic hypoperfusion seen preeclampsia suggested to be part an increased maternal inflammatory response In this study, we aimed evaluate some markers pre-eclamptic normotensive pregnants.
In vitro literature studies have suggested that atherosclerotic oxidized low density lipoprotein (OxLDL) inhibits trophoblast invasion. The objective of this study was to determine the levels OxLDL and examine relationship between antioxidative estradiol, estriol, prooxidative progestin in normal preeclamptic placental tissues measure serum activity paraoxonase (PON1). included 30 32 pregnant women. determined with ELISA, unconjugated progesterone were chemiluminescence method tissues. Serum...
RESULTS:The mean pleural effusion volume, calculated LW/BW ratio, serum IL-6 and lung tissue MDA levels were significantly lower in EPO groups than ANP groups.No statistically significant difference was observed either or values of IL-2 among the groups.The level tumor necrosis factor-α (TNF-α) accumulation ox-LDL evident tissues when compared to groups, particularly at 72 h.Histopathological evaluation confirmed improvement injury parameters after exogenous administration, 48 h h. C O N L U...
The aim of the present study was to examine probable relationship between accumulation oxLDL and hepatic fibrogenesis in cholestatic rats. There is growing evidence support current theories on how oxidative stress that results lipid peroxidation involved pathogenesis liver injury fibrogenesis. One major early products, OxLDL, thought play complex roles various immuno-inflammatory mechanisms. A prolonged (21-day) experimental bile duct ligation performed Wistar-albino Biochemical analysis...
Background and Objective Periodontitis, a chronic inflammatory disease caused by oral bacterial infection, is considered to be risk factor for systemic diseases including diabetes mellitus, pneumonia, hyperlipidemia atherosclerosis. The aim of this study was evaluate the effectiveness melatonin against periodontal inflammation‐induced multiple organ injury in rats. Material Methods Eighteen female Wistar albino rats were randomly divided into three groups six each: control;...
Abstract Synthesis of Poly(methyl methacrylate), PMMA‐multigraft copolymers derived from linseed oil, soybean and linoleic acid PMMA‐ g ‐polymeric oil/oily acid‐ ‐poly(3‐hydroxy alkanoate) (PHA), their protein adsorption bacterial adherence have been described. Polymeric peroxides [polymeric oil peroxide (PSB), polymeric (PLO), (PLina)] initiated the copolymerization MMA unsaturated PHA‐soya to yield PMMA–PLO–PHA, PMMA–PSB–PHA, PMMA–PLina–PHA multigraft copolymers. were completely soluble...
Abstract To diversify edible‐oil polymer composite, polymeric linoleic acid (PLina) peroxide was obtained by the auto‐oxidation of in a simple way for use as macroinitiator free radical polymerization vinyl monomers. Peroxidation, epoxidation, and/or perepoxidation reactions under air at room temperature resulted PLina, having soluble fraction more than 91 weight percent (wt%), with molecular ranging from 1,644 to 2,763 Da, and containing up 1.0 wt% peroxide. PLina initiated ether styrene...
Atrial fibrillation is one of the most common arrhythmias associated with not only increased morbidity after coronary artery bypass grafting but also healthcare costs. Many factors are atrial onset grafting. We prospectively examined which could predict grafting.Fifty-seven consecutive patients (37 men, mean age=60.2+/-12 years) sinus rhythm before included study. Clinical, demographic, laboratory and echocardiographic characteristics all evaluated prospectively. The maximum minimum P-wave...
The aim of this study was to determine the normal values serum IGF-1 and IGFBP-3 in Turkish children adults (1-79 years).The included 571 healthy 625 from West Black Sea region Turkey. Serum concentrations were determined using a chemiluminescent immunometric assay on an Immulite 1000 analyzer.IGF-1 levels tended be higher girls compared boys among children. differences statistically significant puberty age 12-14 years for prepubertally 9-10 IGFBP-3. Peaks observed 2 earlier (14 years) than...
Cardiac complications are often developed after subarachnoid hemorrhage (SAH) and may cause sudden death of the patient. There reports in literature addressing ischemia modified albumin (IMA) as an early useful marker diagnosis ischemic heart events. The aim this study is to evaluate serum IMA by using cobalt binding (ACB) test first, second, seventh days experimental SAH rats.Twenty-eight Wistar albino rats were divided into four groups each consisting seven animals. These classified...
Objectives: The circumventricular organs (CVOs) are essential for most autonomic and endocrine functions. Trauma bleeding can affect their function. aim of this study was to investigate apoptosis necrosis in CVOs the early period after experimental subarachnoid hemorrhage (SAH) rats, using annexin V affinity caspase 3 immunostaining.Methods: Three groups were used: Days 1 2 SAH, a control group, seven Wistar albino rats each. Subarachnoid accomplished by transclival basilar artery puncture....
Introduction: Resveratrol (RSV) is a natural polyphenolic compound found in grape skins and the red wine which improves histological reorganization of regenerating tissue dermal wound healing. Since anastomotic healing possesses paramount importance to prevent complications colorectal surgery, present study aimed evaluate effect RSV on experimental left colonic anastomoses. Methods: Thirty-two male Wistar albino rats were randomized into two groups subjected anastomosis. The group was...
Intestinal ischemia/reperfusion (I/R) is a complex phenomenon that causes destruction of both local and remote tissues. The objective this study was to investigate the possible participation oxidized low-density lipoproteins (oxLDLs) inducible nitric oxide synthase (iNOS) expression in renal tissue damage after intestinal I/R. superior mesenteric artery blocked for 30 minutes, followed by 24 hours reperfusion. At end reperfusion period, tissues were removed; presence oxLDL, superoxide...
<i>Background:</i> The contribution of genetic factors in hypertension cannot be denied. <i>Methods:</i> In this study we evaluated the relationship between vitamin D receptor (VDR) gene polymorphisms (<i>Bsm</i>-I, <i>Apa</i>-I and <i>Fok</i>-I), target organ damage 74 patients (female/male 49/25, mean age 49.2 ± 8 years) with essential hypertension. VDR genotypes were by polymerase chain reaction digestion amplified products...