A5036619376- Curcumin's Biomedical Applications
- Reproductive Biology and Fertility
- Health Education and Validation
- Pancreatic function and diabetes
- Retinoids in leukemia and cellular processes
- Thermal Regulation in Medicine
- Virus-based gene therapy research
- Historical Turkish Studies
- Respiratory Support and Mechanisms
- Effects of Radiation Exposure
- Pesticide Exposure and Toxicity
- Cardiovascular Disease and Adiposity
- Ovarian function and disorders
- Helicobacter pylori-related gastroenterology studies
- Cancer Research and Treatments
- Pharmacological Effects of Natural Compounds
- Humic Substances and Bio-Organic Studies
- Digital Imaging for Blood Diseases
- Nursing Diagnosis and Documentation
- Dental Research and COVID-19
- Sleep and Wakefulness Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inhalation and Respiratory Drug Delivery
- Genital Health and Disease
- Adipose Tissue and Metabolism
Bülent Ecevit University
2015-2025
Aim: Capsaicin is a compound that possesses antioxidant and anti-inflammatory properties, it found in almost all bitter fruits. The objective of our study was to investigate the protective effect capsaicin an ethanolic ulcer model. Materials Methods: male Wistar albino rats were divided into four groups, comprising control group three experimental groups (n=8). (C) administered single dose distilled water subcutaneously. (CAP) 1 mg/kg CAP via gavage. 1ml absolute alcohol gavage, 30 minutes...
Context Carbon tetrachloride (CCl4) is a chemical that still widely used in industry and has been shown to cause structural defects rat testicles through oxidative stress. Aims In our study, the effect of curcumin on CCl4-mediated testicular damage was investigated. Methods Twenty-four adult Wistar albino male rats weighing 300–350 g were divided into four groups: control group (olive oil applied by gavage every consecutive day for 3 weeks); CCl4 + groups (200 mg/kg dissolved olive given...
This study aimed to explore whether PARP-1 regulatory pathway mediated X irradiation induced cell cycle arrest and apoptosis or not. In this regard, colonic mucosal injury caused by whole-body X-irradiation through PARP-1, caspase 3 p53 were evaluated in experimental rat models. Eighteen Wistar albino rats divided into three groups. Two radiation groups received 8.3 Gy dose of as a single the control group physiological saline intraperitoneally. Radiation sacrificed after 6 h 4 days...
Ionising radiation exposure of 5-10gray (Gy) to the pelvic area induces premature ovarian failure (POF). Twenty-four young adult Wistar albino female rats were treated with subcutaneous capsaicin 0.5mg/kg per day or placebo for 10days then exposed whole body irradiation. Rats randomly divided into four groups: (1) control; (2) capsaicin; (3) only (IR): injected before a single dose 8.3-Gy irradiation; (4) radiation-capsaicin (IR+CAP): prior Radiation triggered oxidative stress, increased...
Background Methotrexate (MTX) is an agent used in the treatment of many neoplastic and non-neoplastic diseases known to cause oxidative damage normal tissues. Curcumin (Cur) a natural polyphenol compound with powerful antioxidant antiapoptotic effects. In this study we investigate effects Cur on MTX-induced ovarian damage.
Curcumin is a natural polyphenol with antioxidant, antiapoptotic and anti-inflammatory properties. In the present study, we explored roles of PARP-1 NF-κB molecules in inflammation apoptosis modulation caused by curcumin ethanol-induced gastric ulcer model. Male wistar albino rats (n=32) were divided into four groups. A single dose 1 mL corn oil was given orally to normal control ethanol After 30 minutes after application, absolute alcohol administered group. The group 100 mg/kg orally....
<title>Abstract</title> Purpose Acute respiratory distress syndrome (ARDS) leads to high morbidity and mortality, with limited pharmacological treatments a reliance on supportive therapies. Recent evidence suggests cannabinoids may offer protective therapeutic benefits against tissue damage, including lung pathologies. While cannabinoids' positive impacts pathologies are known, their specific effects ARDS mechanisms have not been thoroughly examined. The study purposes explore the of injury...
Acute respiratory distress syndrome (ARDS) is a serious pulmonary reaction with well-defined clinical parameters in humans triggered by many causes besides bacterial and viral pneumonia. However, there no definitive definition of ARDS the experimental animal model. With its 2010 workshop report, American Thoracic Society defined main histopathological features that determine presence laboratory animals, such as changes parenchymal tissue, altered integrity alveolar capillary barrier,...
Aim: The aim of this study was to compare the histomorphometric and immunohistochemical properties heart aorta in young adult aged rats. Material Methods: Sixteen female Wistar albino rats, eight (6 months old, female, 233.25±13.85 g) rats were used study. sacrificed under high dose anaesthesia aortic tissues collected. Ventricular septum interventiculare thicknesses measured on tissues, tunica media, intima thickness diameter histomorphometrically tissues. In addition, Inducible Nitric...
Purpose: Acute respiratory distress syndrome (ARDS) leads to high morbidity and mortality, with limited pharmacological treatments a reliance on supportive therapies. Recent evidence suggests cannabinoids may offer protective therapeutic benefits against tissue damage, including lung pathologies. While cannabinoids' positive impacts pathologies are known, their specific effects ARDS mechanisms have not been thoroughly examined. The study purposes explore the of injury in direct indirect...
Aim: Immunohistochemistry is still frequently preferred in both diagnostic and experimental studies
 because it can show proteins where they are the tissue. One of main problems immunohistochemistry
 background staining, which be prevented by protein blocking occurs as
 a result binding primary antibodies to tissue Fc receptors due antigenic
 similarity. There no consensus on whether wash after current publications and
 immunohistochemistry manuals published...
Amaç: Kanıta dayalı tıp (KDT) uygulamaları, Tıp Fakültesi öğrencilerinin tıbbi araştırmaların
 tasarlanması, yürütülmesi, bulguların analizi ve sunumu alanlarında tecrübe kazanmalarını amaçlar. Bu
 sayede eleştirel düşünme bilimsel akıl yürütme yeteneği kazanmış hekimlerin sağlık akademik
 camiaya kazandırılmasını hedefler.
 Gereç Yöntemler: KDT dersi, Zonguldak Bülent Ecevit Üniversitesi Dönem III ders
 programı içinde yer almaktadır. Öğrencilerin araştırma...
Abstract Study question Is capsaicin effective in preventing radiation induced ovarian follicle loss and premature failure (POF) rats? Summary answer Capsaicin pre-treatment before radiotherapy restores especially primordial pool, inhibits atresia of follicles, may be an acceptable therapeutic modality to prevent POF. What is known already Ionizing exposure pelvic area induces inflammation, oxidative stress, follicular apoptosis; leading Phytochemicals were used animal studies POF because...