Extensive research has been focused on radiation-induced brain injury. Animal and human studies have shown that flavonoids remarkable toxicological profiles. This study aims to investigate the neuroprotective effects of quercetin in an experimental A total 32 adult male Wistar-Albino rats were randomly divided into four groups (control, quercetin, radiation, radiation+quercetin groups, with eight each group). Doses (50 mg/kg) administered animals groups; radiation exposed a dose 20 Gy...

Our aims are to determine whether the urinary neutrophil gelatinase-associated lipocalin (uNGAL) can predict acute kidney injury (AKI) development in nonseptic and nonasphyxiated but critically ill preterm infants.Fifty infants, gestational age (GA) between 28 34 weeks, were included this case control study. Blood urine samples taken for blood urea nitrogen, serum creatinine, uNGAL on postnatal (PN) days 1 7. levels measured by enzyme-linked immunoassay. Clinical laboratory characteristics...

Objective: The aim of this study is to determine the reference values serum Cystatin C (CysC) and CysC-based estimated glomerular filtration rate (GFR) on 3rd 30th day life in comparison with creatinine (Cr) Cr-based GFR.Methods: This prospective was performed 52 preterm neonates whose gestational ages were between 28 34 weeks. Preterm divided into three groups according age as follows: week 28–29 (group 1), 30–32 2) 33–34 3). Blood samples obtained days life. CysC determined by...

In this study, it was aimed to evaluate the effect of ethanol extract Annona Muricata (AM) leaves in prevention brain damage caused by ionizing radiation (IR). This study conducted Experimental Animal Research Unit a university with 28 adults female Wistar Albino rats. The experimental groups were as follows: Control group (n = 8), AM 6), IR + 6). group, astrocyte hypertrophy, microglial reaction and inflammatory levels significantly higher than control (P < 0.001). Edema compared (P=0.001)....

The aim of this study was to evaluate and compare the effect radiotherapy on testicles with different treatment positions plans for rectal cancer patients.Mono-institutional prospective study.Three plans; supine 4-fields (s4f), prone (p4f), 3-fields (p3f) 15 male patients carcinoma receiving 45 Gy pelvic were evaluated. Testicular doses in each plan calculated. Since localizations primary tumor may affect testicular dose, boost not taken into account.Kruskal Wallis test, Pearson Spearman...

Ionising radiation exposure of 5-10gray (Gy) to the pelvic area induces premature ovarian failure (POF). Twenty-four young adult Wistar albino female rats were treated with subcutaneous capsaicin 0.5mg/kg per day or placebo for 10days then exposed whole body irradiation. Rats randomly divided into four groups: (1) control; (2) capsaicin; (3) only (IR): injected before a single dose 8.3-Gy irradiation; (4) radiation-capsaicin (IR+CAP): prior Radiation triggered oxidative stress, increased...

Radyasyona Bağlı İntestinal Hasarda Quercetin'in Koruyucu EtkisiAim: The aim of this study was to evaluate the protective use quercetin in a rat model radiation-induced enteritis and colitis.Methods: Twenty four adult rats were randomly divided into groups.Group SHAM given only physiological saline, group QUER 50 mg/kg for 15 days, RAD irradiation QUER+RAD mg/kg, then irradiated.Twenty hours after exposure radiation, all euthanized evaluation ileum colon morphology biochemical...

Abstract Background: Intensity-modulated radiotherapy (IMRT) is a widely used irradiation technique in rectal cancer patients. We aimed to compare 4 different IMRT plans with 3-dimensional conformal (3D-CRT) considering organs at risk (OARs) patients carcinoma. Methods: This retrospective study included 27 who were irradiated preoperatively between January 2016 and December 2018. Five (4-field 3D-CRT 2 phases, 7-field 9-field simultaneous integrated boost [SIB] IMRT, SIB IMRT) generated for...

surgery (BCS) to those having undergone modified radical mastectomy (MRM). Material and Methods: Forty-four BCS 27 MRM patients have been included in this retrospective study. All completed adjuvant chemotherapies radiation therapies. who received breast reconstruction afterwards, experienced local or distant organ relapse, over fifty years old excluded. Each patient’s quality of life has evaluated using the Short Form 36 (SF-36), 6 months after completion their treatment. Results: Between...

Objective: The spinal cord is often involved in radiotherapy to treat malignancies and considered as one of the most critical dose-limiting organs. Histopathological changes radiation-induced injury include gliosis, demyelination, necrosis white matter, well vascular both gray matter. All aerial parts Annona muricata (AM) are used traditional medicine practices, previous studies revealed that AM leaf extract has radioprotective effect against gamma- irradiation. This study aimed evaluate...

Objectives: Active and adaptive coping strategies have been identified as factors that can assist cancer patients in effectively managing overcoming the crisis, leading to potential for post-traumatic growth during diagnosis treatment stages. Psychological flexibility is another factor protect individuals promote more reactions traumatic situations. The study aims examine investigation of mediation role with stress relationship between psychological posttraumatic patients. Methods: This was...

Abstract Objectives This study investigates the effect of Annona muricata (AM) leaf extract against irradiation-induced damage by evaluation hepatic tissue and levels oxidative inflammatory stress in circulation. Methods An experimental with 37 female Wistar albino rats randomized into four groups (controls three intervention groups) was performed. The first interventional group (group 2) received 300 mg/kg AM oral gavage once a day for 9 days, 3 single dose whole-body radiation (8.3 Gy)...

Abstract Objective: In the era of neoadjuvant chemotherapy (NAC), most accurate method for axillary staging is a challenge surgeon. Sentinel lymph node biopsy (SLNB) recommended choice care in clinically node-negative (cN0) disease. Nevertheless, role preoperative ultrasound (AUS) or 18F-FDG PET/CT case cN0 patients after NAC (ycN0) controversial. The purpose presented study to assess correlation between surgeon performed AUS and data with SNLB results further determine predictive pathologic...

Abstract We report the radioprotective attitude of Annona muricata (AM) leaf extract as antioxidant material to prevent cellular damage in ileum tissue. The protective effects an ethyl acetate AM leaves are comprehensively investigated against radiation-induced ileal numerous rats. Thirty-two adult female rats were separated into 4 groups (3 intervention and 1 control) follows: controls received 0.01 mL/kg distilled water, group 300 mg/kg extract, ionizing radiation (IR) a single dose whole...

Anahtar kelimeler: Mide kanseri, kemoradyoterapi SUMMARY The Results of Postoperative Chemoradiotheapy in Gastric Carcinoma Patients: Bulent Ecevit University Experience Objective: treatment results postopeative chemoradiotherapy patients with gastric carcinoma were evaluated. Material and Methods: A total 77 carcinoma, treated postoperative between 2007-2011, evaluated retrospectively. Chemoradiotherapy was applied accordance the Integroup-0116 study protocol. Total 45 Gy radiotherapy...

Aim: Liver is mostly exposed to radiation during radiotherapy the upper abdomen, right lobe of lung, distal esophagus tumors or total body irradiation. Radiation may lead cellular damage, and clinical laboratory findings liver dysfunction. This study aimed investigate protective effect peroral hesperidin on reducing oxidative stress in tissue caused by ionızing Material Methods: 24 adult male rats were randomly divide into four groups. Group control was given only physiological saline, HES...