Abstract Background Renal fibrosis is considered an irreversible pathological process and the ultimate common pathway for development of all types chronic kidney diseases renal failure. Diosmin a natural flavonoid glycoside that has antioxidant, anti-inflammatory, antifibrotic activities. However, whether protects kidneys by inhibiting unknown. We aimed to investigate role in interstitial explore underlying mechanisms. Methods The UUO mouse model was established gavaged with (50 mg/kg·d 100...

Background The objective of this study was to develop and validate a machine learning (ML) model for predict in-hospital mortality among critically ill patients with congestive heart failure (CHF) combined chronic kidney disease (CKD).

Abstract This study aimed to establish and validate a machine learning (ML) model for predicting in-hospital mortality in patients with sepsis-associated acute kidney injury (SA-AKI). collected data on SA-AKI from 2008 2019 using the Medical Information Mart Intensive Care IV. After employing Lasso regression feature selection, six ML approaches were used build model. The optimal was chosen based precision area under curve (AUC). In addition, best interpreted SHapley Additive exPlanations...

Carbon dots (CDs) are new carbon nanomaterials, among which those prepared from biomass popular due to their excellent optical properties and environmental friendliness. As representative natural phenolic compounds, tea polyphenols ideal precursors with fluorescent aromatic rings hydroxyl structures. Usually, polyphenolic can only be used produce blue or green CDs, fluorescence in long wavelength domains, such as orange red, cannot achieved. Herein, the high reactivity of groups...

Abstract Background This study aimed to explore the prevalence and related risk factors of sarcopenia in patients on maintenance hemodialysis (MHD). Methods cohort enrolled 165 MHD. The were divided into non-sarcopenia groups based presence or not. Sarcopenia was diagnosed according consensus Asian Working Group that considers reduced muscle mass decreased strength (19). measured using multi-frequency bioelectrical impedance (Inbody260) skeletal index (SMI) used: <7.0 kg/m 2 (male);...

Multicolor solid-state fluorescent CDs were prepared by a one-step solvothermal method using citric acid as the carbon source and six alkyl amines carbonization solvents. We found that chain type of amine solvent significantly affects interaction between dots in solid state thus fluorescence wavelength quantum efficiency CDs.

Bioorganic fertilizers can alleviate (a) biotic stresses and sustainably increase crop yields. The effect of bioorganic on the rhizosphere bacterial community Panax notoginseng soil metabolism remains unknown. Here, we tracked changes in physicochemical properties, microbiota responses, metabolic functions after addition a fertilizer P. field. application reduced acidification, improved organic matter, increased contents total/available nutrients. Soil amendment with significantly affected...

Estimation of Remaining Useful Lifetime (RUL) discrete power electronics is important to enable predictive maintenance and ensure system safety. Conventional data-driven approaches using neural networks have been applied address this challenge. However, due ignoring the physical properties target RUL function, can result in unreasonable estimates such as going upwards wrong endings. In paper, we apply fundamental principle Physics-Informed Neural Network (PINN) enhance Recurrent (RNN) based...

The choices of matrices and protocols for sample deposition are critical factors, which impact each other in the matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI). Previous reports on MALDI MS have only compared their performances terms signal intensities provided optical microphotos or images spots but typically lacked quantitative evaluation. Therefore, there is an urgent need to develop a multivariate model evaluate performance different combinations...

To determine the effects of roxadustat on calcification when treating renal anemia in end-stage kidney disease (ESKD) patients. A prospective cohort study enrolled participants with ESKD that either received or no treatment. The primary outcome was change degree hydroxyapatite (HAP) crystals deposition. secondary propensity, a measure calcification, allowing an evaluation conversion process from to calciprotein particles. total 205 patients were enrolled, and 187 (91.2%) completed follow-up...

The objective of this study was to investigate the effects simvastatin (SIM) on lipid metabolism disorders and gut microbiota in high-fat diet-induced hyperlipidemic rats. obtained results revealed that feeding rats with SIM (20 mg/kg/day) significantly decreased serum level inhibited hepatic accumulation steatosis. Histological analysis further indicated reduced deposition adipocytes hepatocytes comparison HFD group. underlying mechanisms administration against HFD-induced hyperlipidemia...

Carbon dots (CDs) are widely used nanomaterials that not only exhibit good biocompatibility and photostability, but also benefit from a simple preparation process easy functionalization, making them promising for broad applications in the fields of heavy metal ion detection optoelectronic devices. Based on excellent optical properties CDs current situation increasing energy shortages, this paper selects natural polyphenolic compound tannic acid (TA) found biomass materials as carbon source...

This study aimed to establish and validate a machine learning (ML) model for predicting in-hospital mortality in critically ill patients with chronic kidney disease (CKD).This collected data on CKD from 2008 2019 using the Medical Information Mart Intensive Care IV. Six ML approaches were used build model. Accuracy area under curve (AUC) choose best In addition, was interpreted SHapley Additive exPlanations (SHAP) values.There 8527 eligible participation; median age 75.1 (interquartile...

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Biomass carbon dots (BCDs) have the advantages of being nontoxic, low cost and simple to prepare, excellent optical properties, good biocompatibility stability, therefore broad application prospects in areas such as heavy metal ion detection optoelectronic devices. Herein, a simple, green, solvent-free method preparing BCDs was developed. CDs with certain fluorescence properties were prepared by pyrolysis at different temperatures using two abundant components (cellulose lignin) biomass...

Chronic kidney disease(CKD) is one of the most prevalent non-communicable health concerns in children and adolescents worldwide; however, data on its incidence, prevalence, disability-adjusted life years (DALYs) trends population are limited. We aimed to assess global, regional national CKD burden adolescents.

In this paper, the insecticidal activity of natural capsaicinoids (NC) and reference ingredients (imidacloprid, abamectin, pyridaben, which are active commercial pesticides) against 14 agricultural insects was studied in both laboratory field. The results showed that median lethal concentration (LC 50 ) 90% values NC were greater than those had a weaker relative toxicity corresponding ingredients. impressive when it used to control Aphis gossypii from Cucumis sativus 152.82 mg L −1 but...

To investigate the predictors of coronary artery calcification (CAC) and its association with cardiovascular events (CVE) in patients stage 3-5 chronic kidney disease (CKD).Two hundred ninety CKD our nephrology department were enrolled from 2018 to May 2019. The levels matrix Gla protein (MGP) interleukin 6 (IL-6) measured via enzyme-linked immunosorbent assay (ELISA) method 131 all. CAC was evaluated computed tomography (CT). covariate factors analyzed by binary logistic regression...

Detection of heavy metal residues in herbal medicines by a high-sensitivity X-ray fluorescence method that couples monochromatic excitation energy dispersive spectrometry and the fast fundamental parameters method.

Interstitial fibrosis is involved in the progression of various chronic kidney diseases and renal failure. Diosmin a naturally occurring flavonoid glycoside that has antioxidant, anti-inflammatory, antifibrotic activities. However, whether diosmin protects kidneys by inhibiting unknown.The molecular formula was obtained, targets related to were screened, interactions among overlapping genes analyzed. Overlapping used for gene function KEGG pathway enrichment analysis. TGF-β1 induce HK-2...

The purpose of this study was to explore the effects fibre-reinforced composites and onlay restorations on fracture resistance cracked teeth. experiments were grouped as follows: intact teeth, crown; onlay; annular ribbond + onlay, laminated fibre post crown, crown crown. maximal Von Mises stress dentin, at crack, pattern under static loading analysed by single-factor analysis variance (ANOVA) post-test LSD. had a significant difference in than (P < 0.05). more favourable fractures pattern,...