A5101814428- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Pleural and Pulmonary Diseases
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- AI in cancer detection
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Tracheal and airway disorders
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Neurological Disease Mechanisms and Treatments
- Cancer Diagnosis and Treatment
- COVID-19 diagnosis using AI
- Colorectal and Anal Carcinomas
- Spondyloarthritis Studies and Treatments
- Adenosine and Purinergic Signaling
- Cancer, Lipids, and Metabolism
Tongji University
2016-2025
Shanghai Pulmonary Hospital
2016-2025
Mianyang Central Hospital
2024
University of Electronic Science and Technology of China
2024
University of South China
2023
North Sichuan Medical University
2023
First People’s Hospital of Zunyi
2022
Zunyi Medical University
2022
First Hospital of Jilin University
2020
Jilin University
2020
Background Preoperative mediastinal staging is crucial for the optimal management of clinical stage I non–small cell lung cancer (NSCLC). Purpose To develop a deep learning signature N2 metastasis prediction and prognosis stratification in NSCLC. Materials Methods In this retrospective study conducted from May 2020 to October population with NSCLC, an internal cohort was adopted establish signature. Subsequently, predictive efficacy biologic basis proposed were investigated external cohort....
BackgroundThis study, based on multicentre cohorts, aims to utilize computed tomography (CT) images construct a deep learning model for predicting major pathological response (MPR) neoadjuvant chemoimmunotherapy in non-small cell lung cancer (NSCLC) and further explore the biological basis under its prediction.Methods274 patients undergoing curative surgery after NSCLC at 4 centres from January 2019 December 2021 were included divided into training cohort, an internal validation external...
This study aimed to investigate the relationship between lymph node micrometastasis and histologic patterns of adenocarcinoma, with a particular focus on their joint effect prognosis. We retrospectively reviewed 235 patients stage I adenocarcinoma from January 2009 December 2009. Lymph was evaluated by immunohistochemical staining for cytokeratin (AE1/AE3) thyroid transcription factor-1. A logistic regression model applied confirm predictive factors micrometastasis. Survival analysis...
To investigate the association between CT imaging features and survival outcomes in patients with primary invasive mucinous adenocarcinoma (IMA).Preoperative image findings were consecutively evaluated 317 resected IMA from January 2011 to December 2015. The long-term assessed by univariate analysis. independent prognostic factors identified multivariate Cox regression analyses. comparison of was investigated using Kaplan-Meier method propensity scores. Furthermore, impact based on different...
Background: Micropapillary/solid (MP/S) growth patterns of lung adenocarcinoma are vital for making clinical decisions regarding surgical intervention. This study aimed to predict the presence a MP/S component in using radiomics analysis. Methods: Between January 2011 and December 2013, patients undergoing curative invasive resection were included. Using "PyRadiomics" package, we extracted 90 features from preoperative computed tomography (CT) images. Subsequently, four prediction models...
Existing prognostic models are useful for estimating the prognosis of lung adenocarcinoma patients, but there remains room improvement. In current study, we developed a deep learning model based on histopathological images to predict recurrence risk patients. The efficiency was then evaluated in independent multicenter cohorts. defined high- and low-risk groups successfully stratified entire cohort. Moreover, multivariable Cox analysis identified as an predictor disease-free survival....
Immune therapy has shown good results in small-cell lung cancer (SCLC), but the impact of immune microenvironment disease is unclear. In this work, we detected expression programmed death 1 (PD-1), PD-ligand (PD-L1), and other biomarkers cancer. We also analyzed correlations between these markers survival SCLC.Protein PD-1, PD-L1, PD-L2, CD3, CD4, CD8, FOXP3 was surgical tissues from 102 SCLC patients by immunohistochemistry.Positive PD-1 on tumor-infiltrating lymphocytes (TILs) found 40.2%...
Invasive adenocarcinoma intraoperatively misdiagnosed as in situ or minimally invasive is more likely to undergo potentially insufficient resection. The purpose of our study was evaluate the diagnostic accuracy frozen section. We retrospectively reviewed 1,111 lung adenocarcinomas from January March 2016 performance A derivation cohort consisting 436 cases diagnosed by section same period were analyzed find predictive factors for final diagnosis. Validation cohorts (first: April June 2016,...
Our study aimed to evaluate the prognostic significance and adjuvant chemotherapy (ACT) benefits of a micropapillary/solid (MS) pattern in patients with stage IB lung adenocarcinoma.Patients pathologically-confirmed adenocarcinoma who underwent surgical resection between January 2009 December 2011 were included. The tumors reclassified into three categories: MS patterns absent (MS-); non-predominant (MS+); predominant (MS++). correlations prognosis ACT recurrence-free survival (RFS)...
The aim of the study was to investigate relationship between ground-glass opacity (GGO) and tumour spread through air space (STAS), as well their joint influence on prognosis stage I lung adenocarcinoma.A total 620 consecutive patients with surgically resected adenocarcinoma January 2011 December 2012 were reviewed retrospectively. relevance STAS GGO analysed by logistic regression, prognostic significance investigated via Kaplan-Meier method Cox regression models. Furthermore, determine...
The International Association for the Study of Lung Cancer (IASLC) recently proposed a new grading system lung adenocarcinoma (LUAD). We aimed to validate prognostic performance and explore its role in guiding strategy lymph node (LN) dissection. retrospectively reviewed 1029 patients with clinical stage I LUAD who underwent surgery between 2011 2013. association mediastinal nodal metastasis was evaluated. To investigate value LN dissection strategies, 3 pathologists evaluated feasibility...
We aimed to characterize the outcomes of sleeve resection after neoadjuvant chemoimmunotherapy for treatment non-small cell lung cancer (NSCLC), including perioperative and oncologic outcomes, identify any impact operative approach on resultant findings.We identified patients with NSCLC who underwent ≥2 cycles between May 2019 April 2021 retrospectively reviewed clinical records. Perioperative data were collected compared video-assisted thoracoscopic surgery (VATS) (n=8) thoracotomy (n=15)...
Background: Limited resection has gradually become an acceptable treatment for lung adenocarcinomas (ADCs) presenting as ground-glass nodules (GGNs). However, its role in ADCs pure solid (PSN) remains unclear. In this study, we aimed to identify potential candidates limited PSN. Methods: We retrospectively reviewed 772 patients from seven hospitals with ⩽2 cm, PSN on computed tomography scans, who had undergone surgery between 2009 and 2013. Histological subtypes were listed 5% increments....
Tumor spread through air spaces (STAS) has three morphologic subtypes: single cells, micropapillary clusters, and solid nests. However, whether their respective clinical significance is similar remains unclear.We retrospectively reviewed 803 patients with resected non-small cell lung cancer (NSCLC) from January to December 2009. Recurrence-free survival (RFS) overall (OS) were compared among stratified by STAS subtypes. We also performed a prospective study of NSCLC resection specimens...
Abstract A 72-year-old man with fever and weakness in both lower limbs underwent thoracolumbar MRI 18 F-FDG PET/CT. The PET/CT scan revealed diffused FDG uptake along the spinal dura mater from T7 to S2 level like a “bottle brush.” Pathologic examination after biopsy of canal lesions manifested granulomatous inflammation. blood test showed cytoplasmic antineutrophil antibody (ANCA) myeloperoxidase-ANCAs were positive, whereas perinuclear ANCA was negative. Eventually, he diagnosed...