A5101894657- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Radiomics and Machine Learning in Medical Imaging
- Lymphoma Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bipolar Disorder and Treatment
- Congenital Heart Disease Studies
- Lung Cancer Research Studies
- Breast Cancer Treatment Studies
- Electrolyte and hormonal disorders
- Cardiac Structural Anomalies and Repair
- Nutritional Studies and Diet
- Gastric Cancer Management and Outcomes
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Pleural and Pulmonary Diseases
- Colorectal Cancer Treatments and Studies
- Reproductive Biology and Fertility
- Effects of Radiation Exposure
- Epigenetics and DNA Methylation
Shanghai Pulmonary Hospital
2018-2025
Tongji University
2018-2025
Nanjing Drum Tower Hospital
2025
Anyang Normal University
2025
Henan Cancer Hospital
2020-2024
Zhengzhou University
2016-2024
Sichuan University
2018-2024
West China Hospital of Sichuan University
2018-2024
Weifang Medical University
2023
Second Affiliated Hospital of Dalian Medical University
2023
// Zizhen Gong 1,2,3,* , Jiefei Zhou Shengnan Zhao Chunyan Tian 4,5 Panliang Wang 1 Congfeng Xu 6 Yingwei Chen 2,3 Wei Cai 1,2,3 and Jin Wu Department of Pediatric Surgery, Xinhua Hospital, Shanghai Jiaotong University School Medicine, Shanghai, China 2 Institute for Research, 3 Key Laboratory Gastroenterology Nutrition, 4 State Proteomics, National Center Proteomics Science (Beijing), Beijing Radiation Beijing, 5 Engineering Research Protein Drugs, Immunology, Institutes Medical Sciences, *...
The International Association for the Study of Lung Cancer (IASLC) recently proposed a new grading system lung adenocarcinoma (LUAD). We aimed to validate prognostic performance and explore its role in guiding strategy lymph node (LN) dissection. retrospectively reviewed 1029 patients with clinical stage I LUAD who underwent surgery between 2011 2013. association mediastinal nodal metastasis was evaluated. To investigate value LN dissection strategies, 3 pathologists evaluated feasibility...
<title>Abstract</title> Background Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) have been used to estimate disease activity in many diseases. Our study aims determine the role of NLR PLR evaluating vasculitis specific organ involvement antineutrophil cytoplasmic autoantibody (ANCA)-associated (AAV). Methods We retrospectively reviewed medical records 81 AAV patients. Clinical characteristics, laboratory investigations Birmingham score (BVAS) were collected....
Herein, we present a copper-catalyzed, three-component intermolecular 1,4-alkylarylation of 1,3-enynes with ethers and aryl boronic acids. This method, driven by α-C(sp3)-H functionalization the oxygen atom in ethers, regioselectively produces various tetrasubstituted allenes from simple, readily available precursors. Key features include mild reaction conditions simple catalytic system.
Lung cancer patients with comorbid interstitial lung disease (LC-ILD) have an increased risk of developing severe or even fatal radiation pneumonitis after thoracic radiotherapy. However, the underlying mechanisms its pathogenesis are still inconclusive. No approved biomarker medicine is available to prevent pulmonary toxicities in LC-ILD patients. Appropriate management for them remains a challenge clinicians due treatment-related complications. To elucidate histopathological...
Abstract Background: MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) is a key component of the CBM complex (CARD9/10/11/14-BCL10-MALT1) downstream Bruton's tyrosine kinase (BTK) in B-cell receptor signaling pathway. Through its unique scaffolding and proteolytic functions, precisely modulates NF-κB pathway regulates cell proliferation, differentiation immunity. major driver subset lymphomas, making it an attractive target for therapeutic intervention. Inhibition...
Abstract Background Pulmonary lymphoepithelioma‐like carcinoma (LELC) is a rare subtype of primary lung cancer. The present study aims at investigating clinicopathological features and prognostic characteristics the resected pulmonary LELC. Methods Patients with LELC were identified in our hospital from December 2008 to 2018. Data these patients retrospectively reviewed, analyzed subsequently. Results In total, 86 enrolled study, including 39 (45.3%) males 47 (54.7%) females. Most serum...
Background The temporal sequence between serum calcium and insulin resistance (IR) their effects on hypertension are unclear. We studied the association IR, with risk of events in a longitudinal cohort conducted China. Methods Results Data from 8653 subjects aged 20 to 74 years an average follow-up 5.3 were analyzed. Serum calcium, fasting 2-hour glucose measured at baseline follow-up. Cross-lagged panel mediation analysis used examine relationship IR its impact incidence. conjoint observed...
Background: Limited resection has gradually become an acceptable treatment for lung adenocarcinomas (ADCs) presenting as ground-glass nodules (GGNs). However, its role in ADCs pure solid (PSN) remains unclear. In this study, we aimed to identify potential candidates limited PSN. Methods: We retrospectively reviewed 772 patients from seven hospitals with ⩽2 cm, PSN on computed tomography scans, who had undergone surgery between 2009 and 2013. Histological subtypes were listed 5% increments....
Tumor spread through air spaces (STAS) has three morphologic subtypes: single cells, micropapillary clusters, and solid nests. However, whether their respective clinical significance is similar remains unclear.We retrospectively reviewed 803 patients with resected non-small cell lung cancer (NSCLC) from January to December 2009. Recurrence-free survival (RFS) overall (OS) were compared among stratified by STAS subtypes. We also performed a prospective study of NSCLC resection specimens...
Background: Approximately 30–70% percent of patients with non-small cell lung cancer (NSCLC) still relapse after receiving complete resection and even suffer distant metastasis. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have gradually replaced chemotherapy to become the first-line postoperative NSCLC treatment because they can effectively inhibit recurrence cancer. However, clinical efficacy neoadjuvant EGFR-TKIs in EGFR: mutant is unclear. The purpose this...
Abstract Background Previous studies have shown that bipolar disorder is closely related to thyroid dysfunction. Psychiatric drugs a large or small effect on function, and hormone levels can also affect the of drug treatment. Therefore, purpose this study assessment function drug-naive across different mood states, with expectation providing support for treatment options. Methods The present cross-sectional study. Patients diagnosed according International Classification Diseases diagnostic...
The effect of the antioxidant capacity diet and its distribution across three meals on mortality risk among cancer patients remains unexplored. We aimed to prospectively investigate association dietary total (DAC) with all-cause, cancer, noncancer survivors. included 5,009 from National Health Nutrition Examination Survey conducted between 1999 2018. adjusted hazard ratio (aHR) was estimated using survey-weighted Cox proportional hazards model. During a median follow-up 7.9 years, 1811...
Objective The treatment of bipolar disorder (BD) remains challenging. study evaluated the impact hypothalamic–pituitary–adrenal (HPA) axis/hypothalamic–pituitary-thyroid (HPT) axis and glucose metabolism on clinical outcomes in patients with depression (BD-D) manic (BD-M) disorders. Methods research design involved a longitudinal prospective study. A total 500 BD aged between 18 65 years treated 15 hospitals located Western China were enrolled Young Mania Rating Scale (YMRS) Montgomery...
Nonalcoholic fatty liver disease (NAFLD) constitutes a commonly diagnosed pathology with perturbed lipid metabolism, which is mainly caused by excessive accumulation of fat in hepatocytes various pathogenic factors. Currently, there are no effective drug treatments for NAFLD. Ferroptosis represents novel form programmed cell death depending on iron, driven large cellular amounts reactive oxygen species (ROS) and peroxides. plays critical regulatory roles the pathogenesis NAFLD,...
We prospectively investigate the accuracy of frozen sections for diagnosing visceral pleural invasion (VPI) by autofluorescence and evaluated its usefulness in sublobar resection.We included patients with lung adenocarcinoma 2 cm or less to evaluate diagnostic performance VPI via a fluorescence microscope. Furthermore, impact on treated resection was assessed another cohort.A total 112 were enrolled. The accuracy, sensitivity, specificity diagnosis 95.5%, 86.8%, 100%, respectively. Sublobar...