A5089821730- Skin Protection and Aging
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Indoor Air Quality and Microbial Exposure
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Gut microbiota and health
- melanin and skin pigmentation
- Air Quality and Health Impacts
- Nail Diseases and Treatments
- Statistical Methods and Inference
- Hormonal and reproductive studies
- Stress Responses and Cortisol
- Per- and polyfluoroalkyl substances research
- Contact Dermatitis and Allergies
- Plant and fungal interactions
- Fatty Acid Research and Health
- Pesticide Exposure and Toxicity
- Animal testing and alternatives
- Genomics, phytochemicals, and oxidative stress
- Thyroid Disorders and Treatments
- Olfactory and Sensory Function Studies
- Machine Learning in Healthcare
- Carcinogens and Genotoxicity Assessment
- Fault Detection and Control Systems
L'Oréal (France)
2017-2024
Abstract Background Polycyclic aromatic hydrocarbons (PAHs) are of environmental and public health concerns contribute to adverse skin attributes such as premature aging pigmentary disorder. However, little information is available on the potential roles chronic urban PAH pollutant exposure cutaneous microbiota. Given microbiota have healthy undesirable phenotypes relationships between PAHs properties, we hypothesize that may be associated with changes in In this study, over two hundred...
Polycyclic aromatic hydrocarbons (PAH) are produced from incomplete combustion of organic matter and released as environmental contaminants activities such transports, wood combustion, coal-fired power plants. In numerous urban areas worldwide, the levels PAH exposure considered critical regarding public health issues. The possibility to detect metabolites biologically incorporated in human hair was demonstrated proposed biomarkers exposure. Nevertheless, distinguish different between...
The high use of pesticides worldwide and the constant exposure humans to these toxic-by-design chemicals have drawn attention on possible consequences human health. However, information general population remain very limited in most countries, especially urban areas. In present work, hair analysis was conducted investigate 204 women living two Chinese cities (Baoding Dalian) 110 30 metabolites following families: organochlorines, organophosphates, carbamates, pyrethroids, neonicotinoids,...
The impact of a chronic outdoor urban pollution on skin aging-related facial signs is poorly referenced topic.To assess, through visual grading and referential photographic atlas, possible differences in some between Chinese women, comparable ages, living two close cities very differently exposed to pollution.The faces cohorts 204 women (2 × 102) same age-groups (25-45 years), Baoding (a highly polluted city) Dalian less city), for at least 15 years, have been analyzed. Standardized...
Abstract Background Chronic nonextreme sun exposure induces two mechanisms of skin pigmentation, causing immediate darkening and delayed tanning. A new molecule, 2‐mercaptonicotinoyl glycine (2‐MNG), has been shown in vitro to inhibit both melanin synthesis via covalent conjugation the thiol group 2‐MNG precursors. Objective To evaluate preventing vivo. Methods In a randomized, intra‐individual controlled study, 33 subjects with melanin‐rich were exposed UV daylight on designated areas back...
Exposure to pollution is a known risk factor for human health. While correlative studies between exposure pollutants such as polycyclic aromatic hydrocarbons (PAHs) and health exist, while in vitro help establish causative connection, vivo comparisons of exposed nonexposed tissue are scarce. Here, we use hair model matrix study the correlation PAH with microstructural changes over time. Two hundred four samples from 2 Chinese cities distinct were collected, chromatographic-mass spectrometry...
Abstract Environmental pollution is composed of several factors, namely particulate matter (PM 2.5 , PM 10 ), ozone and Ultra Violet (UV) rays among others first the most exposed tissue to these substances skin epidermis. It has been established that disorders such as eczema, acne, lentigines wrinkles are aggravated by exposure atmospheric pollution. While pollutants can interact with surface, contamination deep ultrafine particles or Polycyclic aromatic hydrocarbons (PAH) might be explained...
Abstract Background The effects of air pollutants, particularly polycyclic aromatic hydrocarbons (PAHs), on the skin microbiome remain poorly understood. Thus, to better understand interplay between microbiomes, and conditions, we applied metagenomics metabolomics analyze PAHs in pollution microbiomes over 120 subjects residing two cities China with different levels pollution. Results differentiated into cutotypes (termed 1 2) distinct taxonomic, functional, resistome, metabolite...
Organic pollutant exposure may alter sex steroid hormone levels in both animals and humans, but studies on mixture effects have been lacking mainly limited to persistent organic pollutants, with few hormones being investigated. Moreover, measurements from a single blood or urine sample not be able reflect long-term status. Using hair analysis, here, we evaluated the relationship between multiclass pollutants 196 healthy Chinese women aged 25–45 years. Associations nine hormones, including...
Endogenous hormones regulate numerous physiological processes in humans. Some of them are routinely measured blood, saliva and/or urine for the diagnosis disorders. The analysis fluids may, however, require multiple samples collected at different time points to avoid high variability concentration some hormones. In contrast, hair has been proposed as an interesting alternative reveal average hormone levels over a longer period. this work, we developed and validated analytical method...
Abstract A balanced scalp microbiome is crucial for health, yet the mechanisms governing this balance and etiology of dysbiosis in disorders remain elusive. We conducted a detailed investigation hair follicles, healthy individuals those with dandruff/seborrheic dermatitis (D/SD). It was demonstrated that inhabiting follicles serves as reservoir microbiome, thereby integrating scalp, follicle, into one functional unit. Using vitro models, we further elucidated assembly interactions follicular...
Dandruff is a common and challenging complaint associated with type of scalp, skin population. Scalp seborrheic dermatitis (SD) more severe manifestation dandruff very itching inflammation. Histamine an interesting biomarker released in scalp affected by SD even though the mechanism not well understood yet. A monocentre clinical study was conducted to confirm relationship between dandruff/SD histamine level Indian Highly sensitive liquid chromatography coupled mass spectrometry used for...
Some pesticides have been shown to interfere with thyroid functions through changes in hormone (TH) levels. However, few human studies explored associations between TH levels and environmental exposure currently used pesticides, including neonicotinoids, phenylpyrazoles, phenoxy acids, azoles. Moreover, such often measure biomarkers of urine or blood, thus reveal only recent exposure. In contrast, hair has demonstrated be a suitable matrix for assessing chronic both persistent nonpersistent...
Abstract Background The effects of air pollutants, particularly polycyclic aromatic hydrocarbons (PAHs), on the skin microbiome remain poorly understood. Thus, to better understand interplay between microbiomes, and conditions, we applied metagenomics metabolomics analyze PAHs in pollution microbiomes over 120 subjects residing two cities China with different levels pollution. Results differentiated into cutotypes (termed 1 2) distinct taxonomic, functional, resistome, metabolite...