A5085389805- melanin and skin pigmentation
- Skin Protection and Aging
- Advanced Fluorescence Microscopy Techniques
- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Dermatology and Skin Diseases
- Skin and Cellular Biology Research
- Advancements in Transdermal Drug Delivery
- Probiotics and Fermented Foods
- Bee Products Chemical Analysis
- Contact Dermatitis and Allergies
- Microbial Metabolism and Applications
- Enzyme Production and Characterization
- Cell Adhesion Molecules Research
- Advanced Chemical Sensor Technologies
- Optical Imaging and Spectroscopy Techniques
- Hair Growth and Disorders
- Connective Tissue Growth Factor Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Acne and Rosacea Treatments and Effects
- TGF-β signaling in diseases
- Dermatologic Treatments and Research
- Pomegranate: compositions and health benefits
- Phytochemicals and Antioxidant Activities
- Photoreceptor and optogenetics research
L'Oréal (France)
2009-2025
Hôpital Saint-Louis
2005
Inserm
2005
Food Process Engineering and Microbiology
2005
To study human skin pigmentation in a physiological vitro model, we developed pigmented reconstructed reproducing the three-dimensional architecture of melanocyte environment and interactions with its cellular partners, keratinocytes, fibroblasts. Co-seeding melanocytes keratinocytes onto fibroblast-populated collagen matrix led to correct integration within epidermal basal layer, but remained amelanotic even after supplementation promelanogenic factors. Interestingly, normalization...
Abstract: Background: Within the solar ultraviolet (UV) spectrum, A rays (UVA, 320–400 nm), although less energetic than B (UVB, 280–320 constitute at least 95% of UV radiation that penetrates deep into skin The are associated with both epidermal and dermal damage resulting from generation reactive oxygen species (ROS). Among them, longest UVA wavelengths (UVA1, 340–400 nm) can represent up to 75% total energy. Therefore, is linked various acute chronic conditions, including increased...
Abstract Characterizing melanins in situ and determining their 3D z-epidermal distribution is paramount for understanding physiological/pathological processes of melanin neosynthesis, transfer, degradation or modulation with external UV exposure cosmetic/pharmaceutical products. Multiphoton fluorescence intensity- lifetime-based approaches have been shown to afford detection, but how can one quantify vivo from multiphoton lifetime (FLIM) data, especially since FLIM imaging requires long...
Abstract Background Chronic nonextreme sun exposure induces two mechanisms of skin pigmentation, causing immediate darkening and delayed tanning. A new molecule, 2‐mercaptonicotinoyl glycine (2‐MNG), has been shown in vitro to inhibit both melanin synthesis via covalent conjugation the thiol group 2‐MNG precursors. Objective To evaluate preventing vivo. Methods In a randomized, intra‐individual controlled study, 33 subjects with melanin‐rich were exposed UV daylight on designated areas back...
Abstract Objective The roots of the herb Paeonia lactiflora (‘White Peony’) are used in association with other herbs traditional clinical cosmetic practice China as oral treatment for skin pigmentary disorders, such brown or dark spots. However, skin‐depigmenting potential root extract and its main ingredient paeoniflorin has been scarcely investigated by topical application. purpose this study was to evaluate efficacy whitening agent Methods (containing 53.25% paeoniflorin) (97% purity)...
The stratum corneum (SC) is a superficial skin compartment that protects the body from outside environment. Any disturbance of this function induces cascading steps molecular and cellular repair in whole epidermis. aim study was to investigate epidermal gene expression following SC removal by tape stripping. Twenty-nine healthy male volunteers were included (27 +/- 4 years old). Tape stripping processed on one inner forearm, other unstripped forearm served as control. Epidermis samples...
Abstract Objective To examine the ability of an extract from traditional Chinese medicine, Polygonum multiflorum Radix, to protect melanocyte viability oxidative stress, a key mechanism in initiation and progression hair greying. Methods assess antioxidant capacity Radix extract, primary human foreskin melanocytes were treated with commercially available added culture medium exposed hydrogen peroxide (H 2 O ), using intracellular reactive oxygen species concentrations glutathione/protein...
With aging, epidermal homeostasis and barrier function are disrupted. In a previous study, we analyzed the transcriptomic response of young skin epidermis after stratum corneum removal, obtained global kinetic view molecular processes involved in recovery. present same analysis was performed aged order to better understand defects which occur with aging. Thirty healthy male volunteers (67 ± 4 years old) were involved. Tape-strippings carried out on inner face one forearm, other unstripped...
Research on new ingredients that can prevent excessive melanin production in the skin while considering efficacy, safety but also environmental impact is of great importance to significantly improve profile existing actives market and avoid undesirable side effects. Here, discovery an innovative technology for management hyperpigmentation described. High-throughput screening tests a wide chemical diversity molecules silico predictive methodologies were essential design original...
By its numerous properties and importance in cheese technology (production of colour, flavour, bacteriocins resistance to salt) Brevibacterium linens is a major ripening bacteria. However, the genetic approach such biological functions has been hindered, up now, by lack tools necessary realise modifications this species. Our objective was demonstrate that it possible genetically modify several strains exhibiting interesting technological properties, especially production sulphur compounds....
There is an increasing need in cosmetic research for non-invasive, high content, skin imaging techniques offering the possibility to avoid performing invasive biopsies and supply a maximum of information on state throughout study, especially before, during after product application. Multiphoton microscopy one these compatible with <i>in vitro</i> vivo</i> investigations human skin, allowing its three-dimensional (3D) structure be characterized sub-μm resolution. Various intra-/extra-cellular...
Characterizing melanins in situ and determining their 3D z-epidermal distribution is paramount for understanding physiological /pathological processes of melanin neosynthesis, transfer, degradation or modulation with external UV exposure cosmetic / pharmaceutical products. Multiphoton fluorescence intensity- lifetime-based approaches have been shown to afford detection, but how can one quantify vivo from multiphoton lifetime (FLIM) data, especially since FLIM imaging requires long image...