Fanny Artaud
A5005831289- Parkinson's Disease Mechanisms and Treatments
- Nutrition and Health in Aging
- Nutritional Studies and Diet
- SARS-CoV-2 and COVID-19 Research
- Neurological disorders and treatments
- Air Quality and Health Impacts
- Physical Activity and Health
- Cerebral Palsy and Movement Disorders
- Obesity, Physical Activity, Diet
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Menopause: Health Impacts and Treatments
- Balance, Gait, and Falls Prevention
- Cancer Risks and Factors
- Health disparities and outcomes
- RNA regulation and disease
- Obsessive-Compulsive Spectrum Disorders
- Health, Environment, Cognitive Aging
- Climate Change and Health Impacts
- SARS-CoV-2 detection and testing
- Autism Spectrum Disorder Research
- Noise Effects and Management
- Nuclear Receptors and Signaling
- Epigenetics and DNA Methylation
- COVID-19 and Mental Health
Université de Versailles Saint-Quentin-en-Yvelines
2016-2024
Inserm
2015-2024
Centre de recherche en Epidémiologie et Santé des Populations
2014-2024
Université Paris-Saclay
2016-2024
Institut Gustave Roussy
2018-2024
Centre National de la Recherche Scientifique
2018-2023
Assistance Publique – Hôpitaux de Paris
2018-2023
Sorbonne Université
2018-2023
Université Paris-Sud
2016-2023
Institut du Cerveau
2022
After an infection by SARS-CoV-2, many patients present with persistent physical symptoms that may impair their quality of life. Beliefs regarding the causes these influence perception and promote maladaptive health behaviors.
<h3>Objective</h3> To investigate the longitudinal dose-effect relationship between dopamine replacement therapy and impulse control disorders (ICDs) in Parkinson disease (PD). <h3>Methods</h3> We used data from a multicenter cohort of consecutive patients with PD ≤5 years9 duration at baseline followed up annually to 5 years. ICDs were evaluated during face-to-face semistructured interviews movement disorder specialists. Generalized estimating equations Poisson models robust variance study...
Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive accumulation deleterious exposures across lifespan. DNA methylation (DNAm) has been proposed as biomarker aging that conserves memory endogenous and exogenous stress during life.We examined association education level, an indicator SEP, lifestyle-related variables with four biomarkers age-dependent DNAm dysregulation: total number...
<b>Objectives</b> To examine the individual and combined associations of unhealthy behaviours (low/intermediate physical activity, consuming fruit vegetables less than once a day, current smoking/short term ex-smoking, never/former/heavy alcohol drinking), assessed at start follow-up, with hazard disability among older French adults to assess role potential mediators, repeatedly, these associations. <b>Design</b> Population based cohort study. <b>Setting</b> Dijon centre Three-City...
Slow gait is common in dementia, but it remains unknown whether the slowing happens many years prior to dementia onset. We therefore examined relationship between slow baseline speed (GS), change GS, and hazard of incident a community dwelling elderly people.A total 3,663 participants dementia-free at (mean age, 73.5 years) were followed up for 9 from prospective cohort (Three-City study, France) (all-cause, Alzheimer's disease, vascular other causes). GS over 6 m was assessed 4 times...
Objectives To determine whether fast gait speed at study baseline and change in had independent associations with disability onset. Design Cohort 11‐year follow‐up (1999–2010). Setting Three‐City Study center, Dijon, France. Participants Community‐dwelling individuals aged 65 to 85 (N = 3,814, 61% female). Measurements Fast (over 6 m) was assessed up five times (mobility (Rosow‐Breslau scale), instrumental activities of daily living ( IADL s; Lawton‐Brody basic ADL Katz scale)) six times. A...
Abstract Taller individuals walk faster but it is unknown whether this advantage persists at older ages. We examined the cross-sectional/longitudinal associations of height with gait speed (GS) in participants from Dijon-Three-City cohort study (France) over 11 years. In 4011 (65–85 y), we measured usual/fast GS (6 m) up to five times. baseline height-GS association varied age using linear regression, and influenced change mixed models. 65 y walked than shorter ones (fast difference between...
Most of the evidence on association between unhealthy behaviors and disability comes from studies in elderly, where reverse causation selection bias may distort associations; thus, based midlife trajectories health are needed. We examined four (physical activity, fruit vegetable consumption, smoking, alcohol), starting over 20 years, with subsequent risk early old age (range = 54-84 years) Whitehall II cohort study. Disability was assessed three times 3 years. A hierarchical indicator...
We aimed to estimate the seropositivity anti-SARS-CoV-2 antibodies in May-June 2020 after first lockdown period adults living three regions France and identify associated risk factors.
Nutrition and lifestyle have been long established as risk factors for colorectal cancer (CRC). Modifiable behaviours bear potential to minimize long-term CRC risk; however, translation of information into individualized assessment has not implemented. Lifestyle-based models may aid the identification high-risk individuals, guide referral screening motivate behaviour change. We therefore developed validated a lifestyle-based prediction algorithm in an asymptomatic European population.
Abstract Background To estimate the seroprevalence of SARS-CoV-2 infection in May-June 2020 after lockdown adults living three regions France and to identify associated risk factors. Methods Participants a survey on COVID-19 from an existing consortium general adult population cohorts Ile-de-France (IDF) or Grand Est (GE) - two with high rate COVID-19, Nouvelle-Aquitaine (NA) – low rate, were asked take dried-blood spot (DBS) for anti-SARS-CoV-2 antibodies assessment. The primary outcome was...
Importance Persistent symptoms after SARS-CoV-2 infection are an emerging public health problem. The duration of these remains poorly documented. Objective To describe the temporal dynamics persistent and factors associated with their resolution. Design, Setting, Participants This cross-sectional study involved 53 047 participants from 3 French adult population-based cohorts (CONSTANCES [Consultants des Centres d’Examens de Santé], E3N/E4N, Nutrinet-Santé) who were included in a nationwide...
Previous cohort studies reported that a single measure of physical activity (PA) assessed at baseline was associated with lower Parkinson disease (PD) incidence, but meta-analysis suggested this association restricted to men. Because the long prodromal phase disease, reverse causation could not be excluded as potential explanation. Our objective study between time-varying PA and PD in women using lagged analyses address for compare trajectories patients before diagnosis matched controls.We...
Nutritional factors are essential for the functioning of immune system and could therefore play a role in COVID-19 but evidence is needed. Our objective was to study associations between diet risk SARS-CoV-2 infection large population-based sample.Our analyses were conducted French prospective NutriNet-Santé cohort (2009-2020). Seroprevalence anti-SARS-CoV-2 antibodies assessed by ELISA on dried blood spots. Dietary intakes derived from repeated 24 h dietary records (at least 6) two years...
BackgroundSince the first version of dietary inflammatory index (DII®) developed in past decade, several other versions have been developed. However, to date no study has attempted compare these with respect their associations biomarkers inflammation.ObjectiveWe aimed investigate relationship between four scores [DII, two energy-adjusted derivatives (E-DII and E-DIIr), Inflammatory Score Diet (ISD)], circulating levels markers adipokines.MethodsThis included 17 637 participants from European...
Healthy lifestyles are inversely associated with the risk of noncommunicable diseases, which leading causes death. However, few studies have used longitudinal data to assess impact changing lifestyle behaviours on all-cause and cancer mortality.
Whether reserve plays a role in Parkinson's disease (PD) patients has received less attention than dementia and been mainly examined relation with cognitive function.To investigate whether the severity progression of motor, cognitive, nonmotor PD symptoms by examining education level (proxy reserve) is associated baseline performance rate progression.We used data from longitudinal cohort (≤5-year duration at baseline) annually followed up to 5 years (n = 393; 41% women; mean age 62.3 years,...
<h3>Background and Objectives</h3> To our knowledge, no study has investigated the effect of exposure to formaldehyde on cognition in general population. Our objective was examine association between occupational cognitive impairment middle-aged young-old adults (≥45 years). <h3>Methods</h3> In French CONSTANCES cohort, function assessed with a standardized battery 7 tests evaluate global function, episodic verbal memory, language abilities, executive functions (e.g., Digit Symbol...
Abstract Despite experimental studies suggesting a disease-modifying role of oestrogens, results from epidemiological on the relation reproductive characteristics and hormonal exposures with Parkinson disease in women are conflicting. We used data E3N cohort study including 98 068 aged 40–65 years 1990 followed until 2018. was ascertained using validation process based drug claim databases medical records. Reproductive were self-reported (11 questionnaires). Associations incidence...
Abstract Background Statins represent candidates for drug repurposing in Parkinson's disease (PD). Few studies examined the role of reverse causation, statin subgroups, and dose–response relations based on time‐varying exposures. Objectives We whether use is associated with PD incidence while attempting to overcome limitations described previously, especially causation. Method used data from E3N cohort study French women (follow‐up, 2004–2018). Incident was ascertained using multiple sources...
The "European Prospective Investigation into Cancer and Nutrition" cohort (EPIC-Europe) is a prospective study including ~520,000 participants recruited across Europe (1991-2000) with in-depth baseline data on nutritional, lifestyle, medical, anthropometric variables, blood samples. Here we introduce EPIC4ND, case-cohort within EPIC designed to identify biomarkers predicting future onset of dementia, Alzheimer disease (AD), Parkinson (PD), amyotrophic lateral sclerosis (ALS). EPIC4ND...
Previous studies showed that baseline slow gait speed (GS) is associated with an increased risk of incident dementia. It unknown what the added value measuring GS repeatedly in order to identify those at higher risk. We examined relationship between GS, change and hazard dementia community-dwelling elderly people (N=3,663) dementia-free (mean age, 73.5y) followed over 9y, from prospective French Three-City study cohort. 296 participants developed during follow-up. Gait was slower up 7 years...
Obesity is a risk factor for several major cancers. Associations of weight change in middle adulthood with cancer risk, however, are less clear. We examined the association and body mass index (BMI) category during 42 cancers, using multivariable Cox proportional hazards models European Prospective Investigation into Cancer Nutrition cohort. Of 241 323 participants (31% men), 20% lost 32% gained (>0.4 to 5.0 kg/year) 6.9 years (average). During 8.0 follow-up after second assessment, 20 960...