A5083853657- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Diverticular Disease and Complications
- Global Cancer Incidence and Screening
- Nutritional Studies and Diet
- Esophageal Cancer Research and Treatment
- Anesthesia and Sedative Agents
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Health Systems, Economic Evaluations, Quality of Life
- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Microscopic Colitis
- Esophageal and GI Pathology
- Health Promotion and Cardiovascular Prevention
- Lung Cancer Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Mycobacterium research and diagnosis
- Folate and B Vitamins Research
- Gallbladder and Bile Duct Disorders
- Gastroesophageal reflux and treatments
- Patient-Provider Communication in Healthcare
- Clinical practice guidelines implementation
Telemark Hospital
2016-2025
University of Oslo
2016-2025
Cancer Registry of Norway
2016-2025
Norwegian Institute of Public Health
2011-2024
Oslo University Hospital
1988-2023
Institutt for Eksperimentell Medisinsk Forskning
2021
Harvard University
2016
Institute of Health Economics
2016
Sørlandet Sykehus
2016
The Maria Sklodowska-Curie National Research Institute of Oncology
2016
The European Society of Gastrointestinal Endoscopy and United Gastroenterology present a short list key performance measures for lower gastrointestinal endoscopy. We recommend that endoscopy services across Europe adopt the following seven measurement evaluation in daily practice at center endoscopist level: <b>1</b> Rate adequate bowel preparation (minimum standard 90 %); <b>2</b> Cecal intubation rate <b>3</b> Adenoma detection 25 <b>4 </b>Appropriate polypectomy technique 80 <b>5</b>...
Although colonoscopy is widely used as a screening test to detect colorectal cancer, its effect on the risks of cancer and related death unclear.We performed pragmatic, randomized trial involving presumptively healthy men women 55 64 years age drawn from population registries in Poland, Norway, Sweden, Netherlands between 2009 2014. The participants were randomly assigned 1:2 ratio either receive an invitation undergo single (the invited group) or no usual-care group). primary end points...
AbstractBackground: Most cases of colorectal cancer (CRC) develop from adenomas. Polypectomy is believed to reduce the incidence CRC, but this effect has never been explored in prospective controlled studies. The aim present study was evaluate polypectomy on a population-based screening program. Methods: In 1983, 400 men and women aged 50-59 years were randomly drawn population registry Telemark, Norway. They offered flexible sigmoidoscopy and, if polyps found, full colonoscopy with...
Colorectal cancer is a major health burden. Screening recommended in many countries.To estimate the effectiveness of flexible sigmoidoscopy screening on colorectal incidence and mortality population-based trial.Randomized clinical trial 100,210 individuals aged 50 to 64 years, identified from population Oslo city Telemark County, Norway. was performed 1999-2000 (55-64-year age group) 2001 (50-54-year group), with follow-up ending December 31, 2011. Of those selected, 1415 were excluded due...
<b>Objective</b> To determine the risk of colorectal cancer after screening with flexible sigmoidoscopy. <b>Design</b> Randomised controlled trial. <b>Setting</b> Population based in two areas Norway—city Oslo and Telemark county (urban mixed urban rural populations). <b>Participants</b> 55 736 men women aged 55-64 years. <b>Intervention</b> Once only sigmoidoscopy or without a single round faecal occult blood testing (n=13 823) compared no (n=41 913). <b>Main outcome measures</b> Planned...
Although colonoscopic surveillance of patients after removal adenomas is widely promoted, little known about colorectal-cancer mortality among these patients.Using the linkage Cancer Registry and Cause Death Norway, we estimated who had undergone colorectal during period from 1993 through 2007. Patients were followed 2011. We calculated standardized incidence-based ratios (SMRs) using rates for Norwegian population at large comparison. guidelines recommended colonoscopy 10 years with...
<h3>Importance</h3> Although some countries have implemented widespread colonoscopy screening, most European not introduced it because of uncertainty regarding participation rates, procedure-related pain and discomfort, endoscopist performance, effectiveness. To our knowledge, no randomized trials on screening currently exist. <h3>Objective</h3> investigate rate, adenoma yield, adverse events population-based in several countries. <h3>Design, Setting, Population</h3> A clinical trial was...
Multidisciplinary, evidence-based guidelines for quality assurance in colorectal cancer screening and diagnosis have been developed by experts a project coordinated the International Agency Research on Cancer. The full guideline document covers entire process of population-based screening. It consists 10 chapters over 250 recommendations, graded according to strength recommendation supporting evidence. 450-page extensive evidence base published European Commission. chapter colonoscopic...
AbstractHoff G, Foerster A, Vatn MH, Sauar J, Larsen S. Epidemiology of polyps in the rectum and colon. Recovery evaluation unresected 2 years after detection. Scand J Gastroenterol 1986, 21, 853-862In an endoscopic population screening study for colorectal among 200 men women, 50-59 age, 215 less than 5 mm diameter were left situ present 2-year follow-up examination. The attendance rate was 102 106 (96%) polyp patients 77 90 (86%) control group. Of 194 polyps, 143 (74%) polyp-bearing...
<h3>Objective</h3> Although serrated polyps may be precursors of colorectal cancer (CRC), prospective data on the long-term CRC risk in individuals with are lacking. <h3>Design</h3> In a population-based randomised trial, 12 955 aged 50–64 years were screened flexible sigmoidoscopy, while 78 220 comprised control arm. We used Cox models to estimate HRs 95% CIs for among ≥1 large polyp (≥10 mm diameter), compared adenomas at screening, and population controls, multivariate logistic regression...
Abstract Background With an increased use of magnetic resonance imaging, the indications for endoscopic retrograde cholangiopancreatography (ERCP) have changed. Consequently, patterns and factors predictive complications after ERCP performed during current routine clinical practice are not well known. Methods A prospective multicentre cohort study was undertaken in 11 Norwegian hospitals. Complications mortality within 30 days were analysed by univariable multivariable regression analysis....
Multidisciplinary, evidence-based guidelines for quality assurance in colorectal cancer screening and diagnosis have been developed by experts a project coordinated the International Agency Research on Cancer. The full guideline document covers entire process of population-based screening. It consists 10 chapters over 250 recommendations, graded according to strength recommendation supporting evidence. 450-page extensive evidence base published European Commission. chapter endoscopy includes...
The long-term effects of sigmoidoscopy screening on colorectal cancer (CRC) incidence and mortality in women men are unclear.To determine the effectiveness flexible after 15 years follow-up men.Randomized controlled trial. (ClinicalTrials.gov: NCT00119912).Oslo Telemark County, Norway.Adults aged 50 to 64 at baseline without prior CRC.Screening (between 1999 2001) with additional fecal blood testing versus no screening. Participants positive results were offered colonoscopy.Age-adjusted CRC...
Abstract Background The presence of cancer-specific DNA methylation patterns in epithelial colorectal cells human feces provides the prospect a simple, non-invasive screening test for cancer and its precursor, adenoma. This study investigates panel epigenetic markers detection adenomas. Methods Candidate biomarkers were subjected to quantitative analysis sets tissue samples from cancers, adenomas, normal colonic mucosa. All findings verified independent clinical validation series. A total...
<b>Objective</b> To compare the effectiveness of flexible sigmoidoscopy in screening for colorectal cancer by patient sex and age. <b>Design</b> Pooled analysis randomised trials (the US Prostate, Lung, Colorectal Ovarian trial (PLCO), Italian Screening Colon Rectum (SCORE), Norwegian Cancer Prevention (NORCCAP)). <b>Data sources</b> Aggregated data were pooled from each on incidence mortality stratified sex, age at screening, colon subsite (distal <i>v</i> proximal)....
<b>Background:</b> Current guidelines recommend surveillance colonoscopies after polyp removal depending on the number and characteristics of polyps, but there is a lack evidence supporting recommendations. This report outlines rationale design two randomized trials one observational study investigating evidence-based strategies following removal. <b>Study endpoints:</b> The EPoS studies started to recruit patients in April 2015. I randomizes 13 746 with low-risk adenomas (1 – 2 tubular size...
The comparative effectiveness of sigmoidoscopy and fecal immunochemical testing (FIT) for colorectal cancer (CRC) screening is unknown.Individuals aged 50-74 years living in Southeast Norway were randomly invited between 2012 2019 to either once-only flexible or FIT every second year. Colonoscopy was recommended after if any polyp ≥10 mm, ≥3 adenomas, advanced CRC found or, subsequent to, >15 μg hemoglobin/g feces. Data this report obtained complete recruitment both groups included 2 full...
Objective New screening tests for colorectal cancer (CRC) are rapidly emerging. Conducting trials with mortality reduction as the end point supporting their adoption is challenging. We re-examined principles underlying evaluation of new non-invasive in view technological developments and identification biomarkers. Design A formal consensus approach involving a multidisciplinary expert panel revised eight previously established principles. Results Twelve newly stated emerged. Effectiveness...
Importance Randomized clinical screening trials have shown that sigmoidoscopy reduces colorectal cancer (CRC) incidence and mortality. Colonoscopy has largely replaced for CRC screening, but long-term results from randomized on colonoscopy are still lacking. Objective To estimate the additional benefit of compared with sigmoidoscopy. Design, Setting, Participants This comparative effectiveness simulation study pooled data 358 204 men women randomly assigned to or usual care in 4 conducted...
Several studies have shown that insufflation of carbon dioxide (CO2) instead air during colonoscopy can reduce postprocedural pain. However, CO2 might also lead to retention in the human body. It was recently this side effect does not occur unsedated patients, but sedation leads impaired respiration. Sedated patients may therefore be more prone retention. This randomized, double-blinded study designed investigate whether sedated patients.A total 103 consecutive undergoing were randomly...
Abstract Background Multiple epigenetic and genetic changes have been reported in colorectal tumors, but few of these clinical impact. This study aims to pinpoint markers that can discriminate between non-malignant malignant tissue from the large bowel, i.e. with diagnostic potential. The methylation status eleven genes ( ADAMTS1 , CDKN2A CRABP1 HOXA9 MAL MGMT MLH1 NR3C1 PTEN RUNX3 SCGB3A1 ) was determined 154 samples including normal mucosa, adenomas, carcinomas colorectum. gene-specific...
Hashimoto disease is a chronic autoimmune thyroiditis. Despite adequate hormone substitution, some patients have persistent symptoms that may be the result of immunologic pathophysiology.To determine whether thyroidectomy improves in with thyroiditis who still despite having normal thyroid gland function while receiving medical therapy.Randomized trial. (ClinicalTrials.gov: NCT02319538).Secondary care hospital Norway.150 aged 18 to 79 years Hashimoto-related euthyroid status replacement...
Objective: Fatigue is a major concern for patients with ulcerative colitis (UC) and Crohn's disease (CD), but evidence from population-based studies regarding fatigue in long-standing inflammatory bowel (IBD) scarce. Our aims were to assess scores the prevalence of chronic IBD 20 years after diagnosis identify variables associated this cohort.Methods: Twenty diagnosis, cohort incident invited follow-up visit that included structured interview, clinical examination, laboratory tests...