A5016432397- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Bioinformatics and Genomic Networks
- Birth, Development, and Health
- Nutritional Studies and Diet
- Global Cancer Incidence and Screening
- RNA modifications and cancer
- Health disparities and outcomes
- Genetic Syndromes and Imprinting
- Cancer Risks and Factors
- Health, Environment, Cognitive Aging
- Cervical Cancer and HPV Research
- Dietary Effects on Health
- Bladder and Urothelial Cancer Treatments
- Intergenerational Family Dynamics and Caregiving
- Food Allergy and Anaphylaxis Research
- Genetic Associations and Epidemiology
- Asthma and respiratory diseases
- Contact Dermatitis and Allergies
- Diet and metabolism studies
- Drug-Induced Adverse Reactions
- Cancer-related molecular mechanisms research
- Folate and B Vitamins Research
- Cancer Genomics and Diagnostics
- Obesity, Physical Activity, Diet
Monash University
2019-2025
Monash Health
2019-2025
Cancer Council Victoria
2016-2025
The University of Melbourne
2016-2024
Australian Regenerative Medicine Institute
2022
Hudson Institute
2018
John Wiley & Sons (United States)
2018
University of Copenhagen
2012-2015
Inserm
1979-2014
Hôpital Paul-Brousse
2012
This is a consensus document produced by expert members of Working Party established the Association Anaesthetists Great Britain and Ireland (AAGBI). It updates replaces previous guidance published in 2003. The AAGBI has on management anaphylaxis during anaesthesia 1990, 1995 2008 update was necessary to disseminate new information. Death or permanent disability from may be avoidable if reaction recognised early managed optimally. Recognition usually delayed because key features such as...
Abstract Low socioeconomic status (SES) is associated with earlier onset of age-related chronic conditions and reduced life-expectancy, but the underlying biomolecular mechanisms remain unclear. Evidence DNA-methylation differences by SES suggests a possible association epigenetic age acceleration (AA). We investigated AA in more than 5,000 individuals belonging to three independent prospective cohorts from Italy, Australia, Ireland. was greater (β = 0.99 years; 95% CI 0.39,1.59; p 0.002;...
Abstract Background Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity mortality. Consequently, identification of genetic environmental contributors to the variation in these measures populations has become a major goal field. Results Leveraging SNP more than 40,000 individuals, we identify 137 genome-wide significant loci, which 113 novel, association study (GWAS) meta-analyses four epigenetic clocks surrogate markers for granulocyte...
The association between aging and cancer is complex. Recent studies have developed measures of biological based on DNA methylation called them "age acceleration." We aimed to assess the associations age acceleration with risk survival from seven common cancers. Seven case-control colorectal, gastric, kidney, lung, prostate urothelial B-cell lymphoma nested in Melbourne Collaborative Cohort Study were conducted. Cancer cases, vital status cause death ascertained through linkage registries....
Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive accumulation deleterious exposures across lifespan. DNA methylation (DNAm) has been proposed as biomarker aging that conserves memory endogenous and exogenous stress during life.We examined association education level, an indicator SEP, lifestyle-related variables with four biomarkers age-dependent DNAm dysregulation: total number...
Summary These guidelines have been prepared by the Standards of Care Committee (SOCC) British Society for Allergy and Clinical Immunology (BSACI) are intended allergists others with a special interest in allergy. As routine or validated tests not available majority drugs, considerable experience is required investigation allergic drug reactions to undertake specific challenge. A missed incorrect diagnosis allergy can serious consequences. Therefore, management best carried out specialist...
Summary Investigation of anaphylaxis during general anaesthesia requires an accurate record events including information on timing drug administration provided by the anaesthetist, as well timed acute tryptase measurements. Referrals should be made to a centre with experience and ability investigate reactions range classes/substances neuromuscular blocking agents (NMBAs) intravenous (i.v.) anaesthetics, antibiotics, opioid analgesics, non‐steroidal anti‐inflammatory drugs (NSAIDs), local...
Summary This guideline advises on the management of patients with egg allergy. Most commonly, allergy presents in infancy, a prevalence approximately 2% children and 0.1% adults. A clear clinical history detection white‐specific IgE (by skin prick test or serum assay) will confirm diagnosis most cases. Egg avoidance advice is cornerstone management. often resolves re‐introduction can be achieved at home if reactions have been mild there no asthma. Patients severe asthma should reintroduction...
Measures of biological age based on blood DNA methylation, referred to as acceleration (AA), have been developed. We examined whether AA was associated with health risk factors and overall cause-specific mortality. At baseline (1990-1994), samples were drawn from 2,818 participants in the Melbourne Collaborative Cohort Study (Melbourne, Victoria, Australia). methylation determined using Infinium HumanMethylation450 BeadChip array (Illumina Inc., San Diego, California). Mixed-effects models...
Monozygotic twins have long been studied to estimate heritability and explore epigenetic influences on phenotypic variation. The similarities of monozygotic assumed be largely due their genetic identity. Here, by analyzing data from a genome-scale study DNA methylation in dizygotic twins, we identified genomic regions at which the similarity is substantially greater than can explained This "epigenetic supersimilarity" apparently results locus-specific establishment epigenotype prior embryo...
The disruption of the circadian timing system (CTS), which rhythmically controls cellular metabolism and proliferation, accelerated experimental cancer progression. A measure CTS function in patients could thus provide novel prediction information for outcomes, help to identify specific therapies. rest-activity rhythm is a reliable non-invasive biomarker, was monitored using wrist watch accelerometer 2 days 436 with metastatic colorectal cancer. relative percentage activity in-bed versus...
Abstract Mendelian-like inheritance of germline DNA methylation in cancer susceptibility genes has been previously reported. We aimed to scan the genome for heritable marks associated with breast by studying 25 Australian multiple-case families. Here we report genome-wide measured 210 peripheral blood samples provided family members using Infinium HumanMethylation450. develop and apply a new statistical method identify based on complex segregation analysis. estimate carrier probabilities...
We conducted a genome-wide association study of blood DNA methylation and smoking, attempted replication previously discovered associations, assessed the reversibility smoking-associated changes. was measured in baseline peripheral samples for 5,044 participants Melbourne Collaborative Cohort Study. For 1,032 participants, these measures were repeated using collected at follow-up, median 11 years later. A cross-sectional analysis between smoking longitudinal changes status conducted. used...
Epigenetic age is an emerging marker of health that highly predictive disease and mortality risk. There a lack evidence on whether lifestyle changes are associated with in epigenetic aging. We used data from 1 041 participants the Melbourne Collaborative Cohort Study blood DNA methylation measures at baseline (1990-1994, mean age: 57.4 years) follow-up (2003-2007, 68.8 years). The Alternative Healthy Eating Index-2010 (AHEI-2010), Mediterranean Dietary Score, Inflammatory Index were as diet...
Abstract DNA methylation may be one of the mechanisms by which alcohol consumption is associated with risk disease. We conducted a large‐scale, cross‐sectional, genome‐wide association study and longitudinal analysis repeated measurements taken several years apart. Using Illumina HumanMethylation450 BeadChip, was measured in blood samples from 5606 Melbourne Collaborative Cohort Study (MCCS) participants. For 1088 them, these measures were using collected median 11 later. Associations...
Abstract Aims To determine whether signs of current depression predict attempts to quit smoking, and short‐term abstinence among those who try, test moderating effects gender cessation support (pharmacological behavioural). Design Prospective cohort with approximately annual waves. Among smokers at one wave we assessed outcomes the next using mixed‐effects logistic regressions. Setting Waves 5–8 Four Country International Tobacco Control Study: a quasi‐experimental study from Canada , USA UK...
Abstract The reliability of methylation measures from the widely used HumanMethylation450 (HM450K) microarray has not been assessed for DNA dried blood spots (DBS) or peripheral mononuclear cells (PBMC), nor combined data different studies. Repeated HM450K in DBS and PBMC samples were available participants six case-control studies nested within Melbourne Collaborative Cohort Study. Reliability was individual CpGs by calculating intraclass correlation coefficient (ICC) based on technical...