A5031152527- Cancer survivorship and care
- Chemotherapy-induced cardiotoxicity and mitigation
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Cancer, Stress, Anesthesia, and Immune Response
- Inflammatory mediators and NSAID effects
- Childhood Cancer Survivors' Quality of Life
- Cancer Risks and Factors
- Cardiovascular and exercise physiology
- Lymphatic System and Diseases
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- Testicular diseases and treatments
- Cardiac Health and Mental Health
- Cardiac Imaging and Diagnostics
- Cancer Treatment and Pharmacology
- Genomics and Rare Diseases
- Cancer, Lipids, and Metabolism
- Cancer-related cognitive impairment studies
- DNA Repair Mechanisms
- Physical Activity and Health
- Genetic Associations and Epidemiology
- Family Support in Illness
- Nutrition and Health in Aging
- Single-cell and spatial transcriptomics
Peter MacCallum Cancer Centre
2016-2024
Tamworth Hospital
2023-2024
Western Health
2019-2023
Victorian Comprehensive Cancer Centre
2018-2019
Stornoway Diamond (Canada)
2019
Royal Children's Hospital
2008
Murdoch Children's Research Institute
2007-2008
Queen Elizabeth Hospital
1984-1987
Royal Victoria Infirmary
1982-1986
Newcastle University
1986
Anthracycline chemotherapy may be associated with decreased cardiac function and functional capacity measured as the peak oxygen uptake during exercise ( V·O2 peak). We sought to determine (a) whether a structured training program would attenuate reductions in (b) imaging is more sensitive marker of injury than current standard care resting left ventricular ejection fraction (LVEF).Twenty-eight patients early stage breast cancer undergoing anthracycline were able choose between (mean ± SD...
Abstract Mendelian-like inheritance of germline DNA methylation in cancer susceptibility genes has been previously reported. We aimed to scan the genome for heritable marks associated with breast by studying 25 Australian multiple-case families. Here we report genome-wide measured 210 peripheral blood samples provided family members using Infinium HumanMethylation450. develop and apply a new statistical method identify based on complex segregation analysis. estimate carrier probabilities...
Breast cancer survivors treated with anthracycline-based chemotherapy (AC) have increased risk of functional limitation and cardiac dysfunction. We conducted a 12-month randomized controlled trial in 104 patients early-stage breast scheduled for AC to determine whether 12 months exercise training (ExT) could attenuate disability (primary end point), improve cardiorespiratory fitness (VO2peak), prevent dysfunction.Women 40 75 years age stage I III were 3 4 days per week aerobic resistance ExT...
Parkinson's disease patients have been shown to abnormal visually evoked cortical potentials (VEPs) pattern stimulation. Whereas dopamine is not an important neurotransmitter in the central visual pathways, retina rich and, together with previous animal and human studies, this suggests that VEPs may be due a biochemical electrophysiological disorder retina. This hypothesis has examined by studying electroretinogram (PERG) of matched control subjects. The amplitudes retinal were significantly...
Physical activity (PA) is important for cancer survivors. Trials of remotely delivered interventions are needed to assist in reaching under-served non-metropolitan The objective this study was ascertain whether wearable technology, coupled with health coaching effective increasing PA breast and colorectal survivors living regional remote areas Australia. Cancer from 5 states were randomized intervention control arms. Intervention participants given a Fitbit Charge 2TM received up 6 telephone...
The study examined whether increased physical activity (PA) in nonmetropolitan cancer survivors was maintained 12 weeks following the PPARCS intervention.
Anthracycline-based chemotherapy (AC) is a common treatment for patients with breast cancer and has been associated dramatic improvement in survivorship. Among early-stage cancer, cardiovascular diseases represent the most cause of mortality,
Importance Few studies have investigated whether the associations between pregnancy-related factors and breast cancer (BC) risk differ by underlying BC susceptibility. Evidence regarding variation in is critical to understanding causes for developing effective risk-based screening guidelines. Objective To examine association risk, including modification a of where scores are based on age family history. Design, Setting, Participants This cohort study included participants from prospective...
The cause of testicular ectopia has long been a mystery, and over the years, many hypotheses have suggested to explain condition. most famous these is that ‘Tails Lockwood’. This developed from paper written in 1888 by Charles Barrett Lockwood. Although little evidence ever found corroborate this hypothesis, it remains textbooks journal articles present day. In 21st century, theory should no longer be given as for ectopic testes. Current biological supports complex process growth, elongation...
To examine practice patterns for breast cancer patients with limited sentinel node (SN) disease in light of the ACOSOG Z0011 results. Retrospective analysis T1-2 and positive lymph biopsy (SLNB) admitted between January 2009 December 2012. Patient demographics, tumor characteristics, treatments were recorded. Eight hundred SLNBs identified. A total 452 (56.5%) proceeded to completion axillary dissection (cALND). cALND rate decreased from 65.1% 49.7% 2009–2010 2011–2012. was performed...
Interventions to increase physical activity (PA) in cancer survivors have often adopted a "one-size-fits-all" approach and may benefit from being tailored psychological constructs associated with behavior. The study objective was investigate the exercise preferences related PA among survivors.Posttreatment colorectal, endometrial, breast (n = 183) living metropolitan nonmetropolitan areas completed survey measures of PA, preferences, attitudes, self-efficacy, perceived behavioral control...
Abstract Background Healthy levels of physical activity and improved fitness have shown better quality life outcomes survival in women with breast cancer. There is a lack baseline data for cancer outpatients Australia. Methods A single centre cross‐sectional study was performed to provide snapshot the attending Surgical Oncology Breast Outpatient Clinic at Western Health, Melbourne. total 200 (aged 18–85 years) were surveyed 6‐min walk test (6MWT) performed. Single multiple linear regression...
Seven normal, young adult, female cats each had its colon evacuated with warm-water enemas (at 24 hours, 12 and one hour) before oral administration of a gelatin capsule containing 20 radiopaque markers to determine normal colonic transit times. Abdominal radiographs were taken twice daily until all expelled. There no significant differences between animals or trials (p = 0.05 less). Markers accumulated in the first section large bowel within eight hours. Evacuation from took another 40...
Visual, cortical somatosensory and brainstem auditory evoked potentials were recorded before incidental irradiation of the rhombencephalon at 11 weeks eight months after completion treatment. No patient experienced neurological symptoms during this period. consistent changes in found. The failure to demonstrate subclinical radiation-induced demyelination suggests either that syndrome early-delayed radiation rhombencephalopathy occurs an idiosyncratic manner, or any lesions are not detectable...
Background Exercise rehabilitation is a promising strategy for reducing cardiovascular disease risk among patients with breast cancer. However, the evidence primarily derived from programs based at exercise centers in-person supervised delivery. Conversely, most report preference home-based rehabilitation. As such, there clear need to explore strategies that can provide real-time supervision and coaching while addressing consumer preferences. Evidence cardiac has demonstrated noninferiority...
INTRODUCTION Adjuvant endocrine therapy (AET) blocks the action of estrogens and is commonly prescribed in hormone receptor-positive breast cancer. Given putative cardioprotective role females, AET may exacerbate negative metabolic side-effects anthracycline chemotherapy. This study examined early effects combined chemotherapy on body composition, exercise tolerance markers cardiovascular risk a cohort females with METHODS was secondary analysis BReast cancer EXercise InTervention (BREXIT)...
Abstract Background Exercise training (ExT) is emerging as a useful therapy to address limitations in VO2peak anthracycline-treated breast cancer (BC) survivors. However, the factors necessary for improving during (neo)adjuvant BC remain unclear. Purpose To explore physiologic that were associated with meaningful increase following 12-month structured ExT intervention survivors undergoing anthracycline-based therapy. Methods This was secondary analysis of BReast EXercise InTervention...
Summary A 38 year old woman who had undergone irradiation during infancy for a left facial cutaneous arteriovenous malformation sequentially developed complete palsies of the ipsilateral VII, V, XI, IX, X, XII and VI cranial nerves. Apart from optic olfactory nerve damage there are few reports radiotherapy causing injury. We link unusually extensive progressive neural prolonged latency to patient’s age at time irradiation.