A5015450904- Inflammatory Bowel Disease
- Microscopic Colitis
- Pharmacological Effects and Toxicity Studies
- Liver Disease Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Vitamin D Research Studies
- Diabetes Management and Research
- Musculoskeletal pain and rehabilitation
- Epilepsy research and treatment
- Bone health and osteoporosis research
- Pain Management and Opioid Use
- Liver Disease and Transplantation
- Musculoskeletal Disorders and Rehabilitation
- Stroke Rehabilitation and Recovery
- Eosinophilic Esophagitis
- Dementia and Cognitive Impairment Research
- Helicobacter pylori-related gastroenterology studies
- Palliative Care and End-of-Life Issues
- Total Knee Arthroplasty Outcomes
- Healthcare cost, quality, practices
- Hip disorders and treatments
- Nutritional Studies and Diet
- Diabetes and associated disorders
- CAR-T cell therapy research
- Diverticular Disease and Complications
The University of Melbourne
2016-2025
The Royal Melbourne Hospital
2015-2025
Monash University
2012-2025
Liverpool Hospital
2024
Australian Regenerative Medicine Institute
2024
The Alfred Hospital
2012-2023
Cabrini Hospital
2020-2023
RMIT University
2012-2023
University of Jyväskylä
2022
Melbourne Health
2012-2021
Comprehensive national joint replacement registries with well-validated data offer unique opportunities for examining the potential future burden of hip and knee osteoarthritis (OA) at a population level. This study aimed to forecast primary total (TKR) replacements (THR) performed OA in Australia year 2030, model impact contrasting obesity scenarios on TKR burden. De-identified THR 2003–2013 were obtained from Australian Orthopaedic Association National Joint Replacement Registry....
Janus kinase (JAK) inhibitors, including baricitinib, block cytokine signaling and are effective disease-modifying treatments for several autoimmune diseases. Whether baricitinib preserves β-cell function in type 1 diabetes is unclear.In this phase 2, double-blind, randomized, placebo-controlled trial, we assigned patients with diagnosed during the previous 100 days to receive (4 mg once per day) or matched placebo orally 48 weeks. The primary outcome was mean C-peptide level, determined...
Summary Background Crohn's disease recurs in the majority of patients after intestinal resection. Aim To compare relative efficacy thiopurines and anti‐TNF therapy at high risk recurrence. Methods As part a larger study comparing post‐operative management strategies, recurrence (smoker, perforating disease, ≥2nd operation) were treated resection all macroscopic with 3 months metronidazole together either azathioprine 2 mg/kg/day or mercaptopurine 1.5 mg/kg/day. Thiopurine‐intolerant received...
Active gaming technologies, including the Nintendo Wii and Xbox Kinect, have become increasingly popular for use in stroke rehabilitation. However, these systems are not specifically designed this purpose limitations. The aim of study was to investigate feasibility using a suite motion-controlled games individuals with undergoing rehabilitation.Four games, which utilised depth-sensing camera (PrimeSense), were developed tested. could be played seated or standing position. Three controlled by...
<h3>BACKGROUND AND PURPOSE:</h3> The 2016 revision of the <i>World Health Organization Classification Tumors Central Nervous System</i> mandates codeletion chromosomes 1p and 19q for diagnosis oligodendroglioma. We studied whether conventional MR imaging features could predict 1p/19q status. <h3>MATERIALS METHODS:</h3> Patients with previous testing were identified through pathology department records, typically performed on basis an oligodendroglial component routine histology; 69 patients...
Abstract Background Electronic health record datasets have been used to determine the prevalence of musculoskeletal complaints in general practice but not examine associated characteristics and healthcare utilisation at primary care level. Aim To describe patients presenting practitioners with complaints. Design setting A five-year analysis within three Primary Health Networks (PHNs) Victoria, Australia. Method We included least one face-to-face consultation 2014 2018 inclusive a low back (≥...
<h3>Objective:</h3> To evaluate fractures and falls in epilepsy patients taking antiepileptic drugs (AED) to assess their awareness of AED-related bone health, falls, fracture risk. <h3>Methods:</h3> A cross-sectional study was conducted AEDs nonepileptic non-AED users. Information on history collected. <h3>Results:</h3> total 150 AED users were compared with 506 Users had greater odds at spine (odds ratio [OR] 3.92; confidence interval [CI] 1.08–14.16; <i>p</i> = 0.037), clavicle (OR 3.75;...
williams a., manias e., walker r. & gorelik a. (2012) A multifactorial intervention to improve blood pressure control in co‐existing diabetes and kidney disease: a pilot randomized controlled trial. Journal of Advanced Nursing 68 (11), 2515–2525. Abstract Aims. The aim this study was test the feasibility impact an consisting self‐monitored pressure, medicine review, Digital Versatile Disc, motivational interviewing telephone calls help people with disease their adherence prescribed...
Catheter-tissue contact is critical for effective lesion creation. We characterized the force (CF) at different anatomic sites during antral pulmonary vein (PV) isolation atrial fibrillation.Two experienced operators performed PV in 22 patients facilitated by a novel CF-sensing ablation catheter blinded fashion. Average CF and force-time integral data from 1602 lesions were analyzed. The left right antra divided into following: carina, superior, inferior, anterior, posterior quadrants...
The isocitrate dehydrogenase 1 (IDH1) R132H mutation is the most common in World Health Organization (WHO) grade II gliomas, reported to be expressed 70-80%, but only 5-10% of high gliomas. Low tumors, especially protoplasmic subtype, have highest incidence tumor associated epilepsy (TAE). IDH1 leads accumulation 2-hydroxyglutarate (2HG), a metabolite that bears close structural similarity glutamate, an excitatory neurotransmitter has been implicated pathogenesis TAE. We hypothesized...
Objective To compare the effectiveness of a novel model care ("Stepping Up") with usual primary in normalising insulin initiation for type 2 diabetes, leading to improved glycated haemoglobin (HbA1c) levels.Design Cluster randomised controlled trial.Setting Primary practices Victoria, Australia, practice nurse and at least one consenting eligible patient (HbA1c ≥7.5% maximal oral treatment).Participants 266 patients diabetes 74 (mean cluster size 4 (range 1-8) patients), followed up 12...
To compare healthcare utilisation outcomes among older hospitalised patients with and without cognitive impairment, to the costs associated these outcomes.Retrospective cohort study of administrative data from a large teaching hospital in Melbourne, Australia 1 July 2006 30 June 2012. People impairment were defined as having dementia or delirium coded during admission. Outcome measures included length stay, unplanned readmissions within 28 days outcomes. Regression analysis was used...
Objective To forecast the prevalence and direct health care costs of osteoarthritis ( OA ) rheumatoid arthritis RA in Australia to year 2030. Methods An epidemiologic model Australian population was developed. Data on national were obtained from Bureau Statistics ABS 2014–2015 National Health Survey. Future estimated using projections for 2020, 2025, Available government data expenditure modeled (in $) years 2030, perspective public system. Results The number people with is expected increase...
OBJECTIVE To investigate if early electronic identification and bedside management of inpatients with diabetes improves glycemic control in noncritical care. RESEARCH DESIGN AND METHODS We investigated a proactive or intervention model care (whereby an inpatient team electronically identified individuals aimed to provide within 24 h admission) compared usual (a referral-based consultation service). conducted cluster randomized trial on eight wards, consisting 10-week baseline period (all...
Abstract Background The optimal dosing strategy of infliximab (IFX) in Acute Severe Ulcerative Colitis (ASUC) is unknown. We compared intensified and standard dose IFX strategies ASUC. Methods In this open-label randomised trial (NCT02770040), patients from 13 Australian centres with intravenous steroid-refractory ASUC were to receive a first 10mg/kg or 5mg/kg 1:2 ratio. Patients the group (intensified induction [II]) received second at day 7 earlier time non-response; all re-randomised 1:1...
To assess the effectiveness of a high- vs low--intensity multidisciplinary ambulatory rehabilitation programme over 12 months for persons in chronic phase after Guillain-Barré syndrome (pwGBS) an Australian community cohort.A total 79 pwGBS, recruited from tertiary hospital, were randomized to treatment group (n = 40) individualized high-intensity programme, or control 39) lower intensity programme. The primary outcome Functional Independence Measure (FIM) motor subscale assessed "activity...