A5027722125- Cancer Risks and Factors
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 Clinical Research Studies
- Heart Failure Treatment and Management
- Prostate Cancer Treatment and Research
- COVID-19 and healthcare impacts
- Prostate Cancer Diagnosis and Treatment
- Advanced Causal Inference Techniques
- Statistical Methods in Clinical Trials
- Physical Activity and Health
- Liver Disease Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Mobile Health and mHealth Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Screening and Detection
- Potassium and Related Disorders
- Acute Myocardial Infarction Research
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Radiomics and Machine Learning in Medical Imaging
- Long-Term Effects of COVID-19
- MRI in cancer diagnosis
- Emergency and Acute Care Studies
- Peanut Plant Research Studies
- Pancreatic and Hepatic Oncology Research
University of Milan
2020-2024
Karolinska Institutet
2022-2024
University of Brescia
2018-2022
Brescia University
2022
University of Milano-Bicocca
2020-2021
Mario Negri Institute for Pharmacological Research
2017-2018
<h3>Importance</h3> Myocardial injury, detected by elevated plasma troponin levels, has been associated with mortality in patients hospitalized coronavirus disease 2019 (COVID-19). However, the initial data were reported from single-center or 2-center studies Chinese populations. Compared these patients, European and US are older, more comorbidities higher rates. <h3>Objective</h3> To evaluate prevalence prognostic value of myocardial a large population White Italian COVID-19. <h3>Design,...
This study sought to demonstrate the statistical and utilitarian properties of restricted mean survival time (RMST) lost (RMTL) for assessing treatments heart failure (HF) with reduced ejection fraction. Although hazard ratio (HR) is most commonly used measure quantify treatment effects in HF clinical trials, HRs may be difficult interpret require proportional hazards assumption valid. RMST RMTL are intuitive summaries groupwise that without model assumptions. Patient time-to-event data were...
Abstract Aims Acute heart failure (AHF) leads to a drastic increase in mortality and rehospitalization. The aim of the study was identify prognostic variables real‐life population AHF patients admitted emergency department with acute shortness breath. Methods results We evaluated potential predictors 728 consecutive AHF. Possible all‐cause cardiovascular (CV) were investigated by Cox Fine Gray models at multivariable analysis. Among patients, 256 died during entire follow‐up, 142 these due...
Myocardial injury (MI) in coronavirus disease-19 (COVID-19) is quite prevalent at admission and affects prognosis. Little known about troponin trajectories their prognostic role. We aimed to describe the early in-hospital evolution of MI its impact.We performed an analysis from Italian multicentre study enrolling COVID-19 patients, hospitalized 1 March 9 April 2020. was defined as increased level. The first tested within 24 h admission, second one between 48 h. Elevated values above 99th...
Background Physical activity is well known to have beneficial effects on glycemic control and reduce risk factors for cardiovascular disease in persons with type 2 diabetes. Yet, successful implementation of lifestyle interventions targeting physical primary care has shown be difficult. Smartphone apps may provide useful tools support activity. The DiaCert app was specifically designed integration into an automated mobile health (mHealth) solution promoting daily walking. Objective This...
Objectives To develop a novel nomogram to identify candidates for active surveillance (AS) that combines clinical, biopsy and multiparametric magnetic resonance imaging (mpMRI) findings; compare its predictive accuracy to, respectively: (i) Prostate Cancer Research International: Active Surveillance (PRIAS) criteria, (ii) Johns Hopkins (JH) (iii) European Association of Urology (EAU) low‐risk classification, (iv) EAU or low‐volume with International Society Urological Pathology (ISUP) Grade...
Abstract Aims Treatment with angiotensin converting enzyme inhibitor (ACEi)/angiotensin II receptors blockers (ARBs) and beta‐blockers is frequently suboptimal at discharge in patients hospitalized for acute heart failure (AHF). We investigated the prognostic significance of medical treatment its changes during hospitalization. Methods results In a retrospective analysis, we included 623 AHF reduced left ventricular ejection fraction (<40%). The primary endpoint was all‐cause mortality...
We investigated the impact of changes in lifestyle habits on colorectal cancer (CRC) risk a multicountry European cohort.
Abstract Aim We investigated the prognostic significance of serum potassium abnormalities at discharge in patients hospitalized for acute heart failure (AHF). Methods and results In a retrospective analysis, we included 926 AHF, stratified by levels as hypokalaemia (<3.5 mEq/L), normokalaemia (3.5–5.0 hyperkalaemia (>5.0 mEq/L). The primary endpoint was all‐cause death 1 year since hospital discharge. At discharge, 40 had (4.3%), 840 (90.7%), 46 (5.0%). Patients with were more...
Background and Aims: The standard treatment of non-metastatic anal squamous cell carcinoma (ASCC) consists chemotherapy with mitomycin (MMC) plus 5-fluorouracil (5FU) for 1–2 cycles concomitant pelvic radiotherapy. Subsequent studies introduced cisplatin (CDDP) combined 5FU, unclear results. We evaluated the doublet capecitabine (C) CDDP as a possible alternative to MMC-5FU regimen intensity-modulated radiation therapy (IMRT). Patients Methods: carried out retrospective study on 67 patients...
Abstract On May 2020, after 2 months of online teaching with no face‐to‐face lectures, the Education Committee Italian scientific Society Medical Statistics and Clinical Epidemiology conceived an survey to assess satisfaction academics medical statistics remote exams. This highlighted teachers' perceptions as well opportunities limitations statistics, biostatistics, epidemiology. Although 61% declared be favorable provide epidemiology in future, we recognize that distance education cannot...
The role of sex compared to comorbidities and other prognostic variables in patients with coronavirus disease (COVID-19) is unclear.This a retrospective observational study on COVID-19 infection, referred 13 cardiology units. primary objective was assess the difference risk death between sexes. secondary explore sex-based heterogeneity association demographic, clinical laboratory variables, patients' death.Seven hundred one were included: 214 (30.5%) women 487 (69.5%) men. During median...
Cervico-vaginal (CV) localization of extra-mammary Paget's disease (EMPD) the vulva is extremely rare. In order to investigate incidence risk and pathognomonic clinical pathological features this condition, a retrospective analysis was conducted including 94 women treated for vulvar EMPD at European Institute Oncology, Milan, Italy, from October 1997 May 2020. Overall nine patients developed CV involvement EMPD, with cumulative 2.5% (95% CI: 0.5-8.0%) 5 years, 6.5% 1.9-15.1%) 10 years 14.0%...
<sec> <title>BACKGROUND</title> Physical activity is well known to have beneficial effects on glycemic control and reduce risk factors for cardiovascular disease in persons with type 2 diabetes. Yet, successful implementation of lifestyle interventions targeting physical primary care has shown be difficult. Smartphone apps may provide useful tools support activity. The DiaCert app was specifically designed integration into an automated mobile health (mHealth) solution promoting daily...