A5005861184- Heart Failure Treatment and Management
- COVID-19 Clinical Research Studies
- Cancer Risks and Factors
- Long-Term Effects of COVID-19
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiovascular Function and Risk Factors
- COVID-19 and healthcare impacts
- Statistical Methods in Clinical Trials
- Tuberous Sclerosis Complex Research
- Acute Myocardial Infarction Research
- Glaucoma and retinal disorders
- Diabetes Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
- Ovarian cancer diagnosis and treatment
- Lung Cancer Treatments and Mutations
- Cardiac electrophysiology and arrhythmias
- Cancer Immunotherapy and Biomarkers
- Potassium and Related Disorders
- Advanced Causal Inference Techniques
- Multiple Sclerosis Research Studies
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Systemic Sclerosis and Related Diseases
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
University of Brescia
2016-2025
Brescia University
2011-2022
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2011-2021
Institute of Cardiology
2021
MultiMedica
1999-2020
Ospedale San Giuseppe
2015-2020
Istituti di Ricovero e Cura a Carattere Scientifico
1999-2019
University of Milan
2006-2015
Medical University of South Carolina
2015
Research to Prevent Blindness
2015
Abstract Aims To compare demographic characteristics, clinical presentation, and outcomes of patients with without concomitant cardiac disease, hospitalized for COVID-19 in Brescia, Lombardy, Italy. Methods results The study population includes 99 consecutive pneumonia admitted to our hospital between 4 March 25 2020. Fifty-three a history disease were compared 46 disease. Among patients, 40% had heart failure, 36% atrial fibrillation, 30% coronary artery Mean age was 67 ± 12 years, 80 (81%)...
<h3>Importance</h3> Myocardial injury, detected by elevated plasma troponin levels, has been associated with mortality in patients hospitalized coronavirus disease 2019 (COVID-19). However, the initial data were reported from single-center or 2-center studies Chinese populations. Compared these patients, European and US are older, more comorbidities higher rates. <h3>Objective</h3> To evaluate prevalence prognostic value of myocardial a large population White Italian COVID-19. <h3>Design,...
Background: Few articles are available about chronic urticaria (CU) impact on patients’ quality of life (QoL). The aim our study was to evaluate QoL in CU patients both focusing health status and subjective satisfaction. We adopted two generic tools: SF‐36 (an questionnaire) SAT‐P (a satisfaction profile). Methods: Twenty‐one untreated (five males, 16 females; aged 46.3 ± 12.4) affected by CU, were enrolled. scores compared with a group 27 respiratory allergy. Published reference values 608...
Abstract Background: The aim of this work was to analyze the diagnostic and prognostic value serum human epididymis protein 4 (HE4) Risk for Ovarian Malignancy Algorithm (ROMA) in epithelial ovarian cancer (EOC). Methods: Preoperative samples 419 women (140 healthy controls, 131 benign cysts, 34 endometriosis, 114 EOC) were tested CA125 HE4 using fully automated methods (Abbott ARCHITECT) validated cutoff values. Results: For discrimination masses from EOC, premenopausal women, sensitivity...
Background. Although the incidence of sudden cardiac death (SCD) is high among haemodialysis (HD) patients, there are few papers available on this topic. The aim study a single-centre HD population observed over 10 year period was to identify patient- and HD-related specific factors that might be associated with higher risk SCD. Methods. included 123 patients (76 men; age 29–79 years) undergoing renal replacement therapy at our dialysis unit for least 6 months. For each patient, routine...
Introduction: To date we have available specific instruments assessing health‐related quality of life (HRQL) in rhinoconjunctivitis or asthma, but not evaluating rhinitis and asthma together, although they often coexist. The aim our study was to develop validate a (QoL) questionnaire for adult patients with rhinoconjunctivitis, both. Materials methods: A pool 42 items covering the main symptoms problems related respiratory allergy, generated based on literature review clinical experience....
Abstract Aims To assess the clinical relevance of a history atrial fibrillation (AF) in hospitalized patients with coronavirus disease 2019 (COVID-19). Methods and results We enrolled 696 consecutive (mean age 67.4 ± 13.2 years, 69.7% males) admitted for COVID-19 13 Italian cardiology centres between 1 March 9 April 2020. One hundred six (15%) had AF median hospitalization length was 14 days (interquartile range 9–24). Patients were older higher burden cardiovascular risk factors. Compared...
The Gail model 2 (GM) for predicting the absolute risk of invasive breast cancer has been used counseling and to design intervention studies. Although GM validated in US populations, its performance other populations is unclear because wide variation international rates.We data from a multicenter case-control study Italy Italian registries develop (IT-GM) that uses same factors as GM. We evaluated accuracy IT-GM using independent Florence-European Prospective Investigation Into Cancer...
Background— Atrial dilatation and atrial standstill are etiologically heterogeneous phenotypes with poorly defined nosology. In 1983, we described 8-years follow-up of evolution in 8 patients from 3 families. We later identified 5 additional identical phenotypes: 1 member the largest original family 4 unrelated to All families same geographic area Northeast Italy. Methods Results— followed up 13 for 37 years, extended clinical investigation monitoring living relatives, investigated genetic...
<b><i>Background:</i></b> Two therapeutic options are currently available for patients with mild-to-moderate idiopathic pulmonary fibrosis (IPF): pirfenidone and nintedanib. To date, there is still insufficient data on the efficacy of these 2 agents in more severe disease. <b><i>Objectives:</i></b> This national, multicenter, retrospective real-life study was intended to determine impact nintedanib treatment IPF....
This study sought to demonstrate the statistical and utilitarian properties of restricted mean survival time (RMST) lost (RMTL) for assessing treatments heart failure (HF) with reduced ejection fraction. Although hazard ratio (HR) is most commonly used measure quantify treatment effects in HF clinical trials, HRs may be difficult interpret require proportional hazards assumption valid. RMST RMTL are intuitive summaries groupwise that without model assumptions. Patient time-to-event data were...
Abstract Aims Acute heart failure (AHF) leads to a drastic increase in mortality and rehospitalization. The aim of the study was identify prognostic variables real‐life population AHF patients admitted emergency department with acute shortness breath. Methods results We evaluated potential predictors 728 consecutive AHF. Possible all‐cause cardiovascular (CV) were investigated by Cox Fine Gray models at multivariable analysis. Among patients, 256 died during entire follow‐up, 142 these due...
Myocardial injury (MI) in coronavirus disease-19 (COVID-19) is quite prevalent at admission and affects prognosis. Little known about troponin trajectories their prognostic role. We aimed to describe the early in-hospital evolution of MI its impact.We performed an analysis from Italian multicentre study enrolling COVID-19 patients, hospitalized 1 March 9 April 2020. was defined as increased level. The first tested within 24 h admission, second one between 48 h. Elevated values above 99th...
The surrogacy of overall response-rate (ORR) or progression-free survival (PFS) for (OS) at the trial-level in randomized clinical trials (RCTs) testing antibody-drugs conjugates (ADC) has never been investigated. RCTs ADCs patients with advanced solid tumors and reporting data on OS PFS and/or ORR were analyzed.The main objective was to assess association between surrogate endpoints (ORR PFS) reference endpoint (OS), subgroups defined by tumor type, number previous lines systemic...
Objective: While many studies have shown an association between the gene coding for adiponectin (ADIPOQ) and levels, much more controversy surrounds its with metabolic traits such as insulin resistance, obesity type 2 diabetes. Furthermore, very few looked into relations ADIPOQ variants risk of cardiovascular disease. The present study assessed influence four common Single Nucleotide Polymorphisms (SNPs), rs17300539 (-11391G→A), rs266729 (-11377C→G), rs2241766 (+45T→G) rs1501299 (+276G→T) on...