A5089625028- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Air Quality and Health Impacts
- Sleep and related disorders
- Health, Environment, Cognitive Aging
- Health disparities and outcomes
- Sleep and Wakefulness Research
- Noise Effects and Management
- Neurological Disease Mechanisms and Treatments
- Climate Change and Health Impacts
- Schizophrenia research and treatment
- Migration, Aging, and Tourism Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Urban Transport and Accessibility
- Functional Brain Connectivity Studies
- Restless Legs Syndrome Research
- Energy and Environment Impacts
- Air Quality Monitoring and Forecasting
- Nutrition and Health in Aging
- Advanced Neuroimaging Techniques and Applications
- Health, Medicine and Society
- Nutritional Studies and Diet
- COVID-19 impact on air quality
- Mental Health Treatment and Access
- Indoor Air Quality and Microbial Exposure
Université de Montpellier
2015-2025
Inserm
2015-2025
Institute for Neurosciences of Montpellier
2021-2024
Hôpital Saint Eloi
2021-2024
Institut de Recherche en Santé, Environnement et Travail
2021
Centre Hospitalier Universitaire de Montpellier
2012-2021
Institut de Génomique Fonctionnelle
2021
Hôpital Paul-Brousse
2021
Neuropsychiatrie : Recherche Epidemiologique et Clinique
2015-2020
Hôpital Gui de Chauliac
2014-2020
Emerging epidemiological evidence suggests a relationship between exposure to air pollution and dementia. However, most of the existing studies relied on health administrative databases for diagnosis In large French population-based cohort (the 3C Study), we assessed effects particulate matter ≤2.5 µm (PM2.5), nitrogen dioxide (NO2) black carbon (BC) risk dementia diagnosed with reliable tools.Participants aged ≥65 years were recruited 1999 2001 followed 12 years. At baseline every 2 years,...
Growing epidemiological evidence suggests an adverse relationship between exposure to air pollutants and cognitive decline. However, there is still some heterogeneity in the findings, with inconsistent results depending on pollutant domain considered. We wanted determine whether pollution was associated global domain-specific decline.This analysis used data from French Three-City prospective cohort (participants aged 65 older at recruitment followed for up 12 years). A battery of tests...
Abstract Background Alzheimer’s disease (AD) is a complex neurodegenerative disorder with β-amyloid pathology as key underlying process. The relevance of cerebrospinal fluid (CSF) and brain imaging biomarkers validated in clinical practice for early diagnosis. Yet, their cost perceived invasiveness are limitation large-scale implementation. Based on positive amyloid profiles, blood-based should allow to detect people at risk AD monitor patients under therapeutics strategies. Thanks the...
Abstract Primary Sjögren’s syndrome (pSS) is an autoimmune disease with frequent neurological involvement. Memory complaints are common, but their precise patterns remain unclear. We wanted to characterize of neurocognitive profiles in pSS patients cognitive complaints. Only memory were included, prospectively. Cognitive compiled through a comprehensive evaluation by neuropsychologists. Evaluations anxiety, depression, fatigue, sleep disorders and quality life performed for testing...
<h3>Background and Objectives</h3> To our knowledge, no study has investigated the effect of exposure to formaldehyde on cognition in general population. Our objective was examine association between occupational cognitive impairment middle-aged young-old adults (≥45 years). <h3>Methods</h3> In French CONSTANCES cohort, function assessed with a standardized battery 7 tests evaluate global function, episodic verbal memory, language abilities, executive functions (e.g., Digit Symbol...
Identifying individuals at risk for dementia and Alzheimer's disease (AD) in the general population (GP) is increasingly essential due to new diagnostic criteria opportunities effective interventions. Plasma-based biomarkers (pBB) offer a promising approach detecting positive amyloid profile. However, their effectiveness predicting clinical AD GP level remains largely unexplored. To assess of using pBB most up-to-date proteomic techniques. Case-cohort study randomly selected from prospective...
The living environment affects general health and may influence cognitive aging; however, the relationships between neighborhood characteristics dementia are still poorly understood.We used data from a French population-based prospective study (the Three-City cohort) that included 7016 participants aged 65 years older with 12-year follow-up. We principal components analysis of composition indicators to construct deprivation score. To its impact on incidence, we performed survival analyses...
Objective: To identify self-reported sleep-wake disturbances that increase the risk of cognitive decline over 1-year follow-up in frail participants. Background: Risk factors for impairment need to be better identified especially at earliest stages pathogenesis. Sleep-wake may critical consider and were thus being assessed this at-risk population decline. Methods: Frail elderly participants aged ≥70 years selected from a subsample Multi-domain Alzheimer Preventive Trial (MAPT) sleep...
Abstract In the last 20 years, many prospective cohort studies have assessed relationships between food consumption and mortality. Result interpretation is mainly hindered by limited adjustment for confounders and, to a lesser extent, small sample sizes. The aim of this study was investigate association dietary habits all-cause mortality in multicentre that included non-institutionalised, community-based elderly individuals (Three-City Study). A brief FFQ administered at baseline. Hazard...
<h3>Objective:</h3> To test the effects of lifetime occupational solvent exposure, as measured by dose and timing, on performance multiple cognitive tests among retired French utility workers. <h3>Methods:</h3> A total 2,143 retirees in GAZEL cohort underwent testing 2010. Lifetime exposure to chlorinated solvents, petroleum benzene was assessed using a job matrix. We modeled dose, timing last combination these metrics risk for impairment. <h3>Results:</h3> Thirty-three percent participants...
Apathy, described as impaired motivation and goal-directed behavior, is a common yet often overlooked multidimensional psychopathological state in schizophrenia. Its underlying cognitive processes remain largely unexplored. Data was drawn from longitudinal hospital study of patients with DSM-IV diagnosis schizophrenia; 137 (82.5%) participated at the 1-month follow-up 81 (59.1%) 1-year follow-up. Apathy assessed Lille Rating Scale, validated French Severe apathy, overall (total score > −13)...
Abstract Background We evaluated if plasma β‐amyloid (Aβ) levels were associated with mortality risks in a subsample of the French Three‐City (3C) prospective cohort study. Methods Analyses based on 1254 participants randomly selected from initial 3C stratified by center, sex, and age context nested case‐cohort study to investigate biological variables. Associations between Aβ assessed Cox regression model delayed entry including various potential confounding factors testing possible...
Objective To determine the relationships between self-reported sleep profile and cortical amyloid load in elderly subjects without dementia. Methods This cross-sectional study included 143 community-dwelling participants aged ≥70 years (median: 73 [70-85]; 87 females) with spontaneous memory complaints but dementia-free. Sociodemographic characteristics, health status, neuropsychological tests, 18F-florbetapir (amyloid) PET data were collected. The clinical interview evaluated nighttime...
Studies of plasma amyloid-β (Aβ) levels as potential biomarkers for incident Alzheimer's disease (AD) have yielded contradictory results. We explored the associations between Aβ40 , Aβ42 and truncated Aβ levels, prognosis dementia in
Socioeconomic level of residential environment was found to influence cognitive performance. However, individuals from the same place residence may be affected differently. We aim investigate for first time individual activity space on association between neighborhood socioeconomic status (NSES) and risk dementia. In frame Three-City cohort, a French population-based study, we followed longitudinally (12 years) 7009 participants aged over 65. The (i.e., spatial area through which person...
Abstract Introduction No evidence exists about the impact of air pollution reduction on incidence dementia. The aim this study was to quantify how quality improvement leads dementia‐incidence benefits. Methods In French Three‐City cohort (12 years follow‐up), we used parametric g‐computation expected number prevented dementia cases under different hypothetical interventions with particulate matter measuring <2.5 μm (PM 2.5 ) reductions. Results Among 7051 participants, 789 participants...
Background: Sophisticated and expensive biomarkers are proposed for the diagnostic of Alzheimer’s disease (AD). The amyloid process seems to be early in AD, brain load affects frontal lobe. Objective: To determine if certain simple clinical signs, especially frontal-related could help reach an earlier better diagnosis. Methods: In frame 3-City cohort, we conducted a nested case-control study comparing incident cases AD controls matched age, gender, education. standardized neurological exam...
Memory troubles and hippocampal atrophy are considered more frequent focal less severe in late-onset (>65 years) than presenile behavioral variant of frontotemporal dementia (bvFTD).To compare cerebrospinal fluid (CSF) plasma biomarkers bvFTD.Multicentric retrospective study (2007-2017) on patients with clinical diagnosis bvFTD.This included 44 (67%) 22 (33%) bvFTD (comparable mean disease duration; n = 11 causal mutations). Hippocampal was (80% versus 25.8%) (median Scheltens score: 3 [0-4]...
Abstract Introduction Cerebrospinal fluid (CSF) biomarker ratios were never evaluated in late‐onset (>65 years) behavioral variant of frontotemporal lobar degeneration (bvFTLD) versus Alzheimer's disease (AD). Methods A retrospective monocentric study on 44 clinically suspected amnestic AD or bvFTLD patients with onset after 65 years and available CSF clinical data. Results The final diagnosis was (n = 28; 64%), 14; 32%), others 2; 4%). Applying the cutoff total‐tau/Aβ 1–42 1.06, all FTLD...
We compared the prevalence of frailty among aging people living with HIV (PLHIV) without from ANS EP58 HAND 55-70 Study.Cross-sectional multicentric study which consecutively included 200 PLHIV and 1000 French national CONSTANCES cohort, matched on age, sex, education level. were aged years, a viral load < 50 copies/mL lymphocyte T-CD4 level > cells/µL for last 24 12 months, respectively. measured (>2 items) prefrailty (one or 2 using proxy 5-item Fried score. Multivariate logistic...