A5064997090- Effects and risks of endocrine disrupting chemicals
- Health, Environment, Cognitive Aging
- Birth, Development, and Health
- Carcinogens and Genotoxicity Assessment
- Pharmaceutical studies and practices
- Romani and Gypsy Studies
- Occupational Health and Performance
- Per- and polyfluoroalkyl substances research
- Biomedical Text Mining and Ontologies
- Animal testing and alternatives
Constantine the Philosopher University in Nitra
2016-2023
We studied occupational exposure to phthalates from first-morning-void urine sample of hairdressing apprentices by HPLC-MS/MS analyses and association with health status. Metabolites mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono ethyl (MEP), mono- n-butyl (MnBP) mono-iso-butyl (MiBP) were detected in all samples, followed metabolites mono(2-ethyl-5-oxohexyl) (MEOHP) mono(2-etylhexyl) (MEHP) occurring 97.06% 86.76% respectively. Positive associations for females observed between MnBP...
Despite increasing attention to the occupational risk of firefighters, little is known about phthalate exposure. In our study, we detected mono-isobutyl (MiBP), mono-n-buthyl (MnBP), mono(2-ethyl-5-hydroxyhexyl) (5OH-MEHP), mono(2-ethyl-5-carboxypentyl) (5cx-MECPP), and mono(2-ethyl-5-oxohexyl) (5oxo-MEHP) in each urine sample. We positive association between MnBP, MiBP, mono-2-ethylhexyl (MEHP), 5OH-MEHP, 5oxo-MEHP, 5cx-MECPP, mono-isononyl (MiNP), sum low (∑LMWP) high molecular-weight...
Background: Occupational health hazards associated with phthalate exposure among nurses are still not well understood. Methods: We used high-performance liquid chromatography and tandem mass spectrometry to analyze phthalates. Anthropometric measurements questionnaires were conducted. Results: observed associations between mono-benzyl (MBzP) body index (BMI), hip circumference (HC), waist (WC), height ratio (WHtR), fat (FMI), visceral content, BMI risk (HIrisk), adjusted consumer behavior...
The objectives of the study were to examine occupational exposure phthalates hairdressing apprentices from Slovakia (n = 74, 89.2% females; 10.8% males), outcomes related body composition and pulmonary functions. We used high-performance liquid chromatography tandem mass spectrometry quantified urinary concentration phthalates. Pulmonary function test (PFT), anthropometric measurements, questionnaire also conducted. observed a decrease % predicted values forced vital capacity (FVC% PV)...
Adverse birth outcomes present risk factors resulting in neonatal morbidity and mortality. Sufficient maternal hormonal concentrations are crucial for normal foetal development. Previous studies have shown a relationship between phthalate exposure levels during pregnancy. This study aims to investigate if anthropometric parameters associated with endocrine the ≤15th week of gestation third trimester pregnancy concerning pregnant women from Nitra, Slovakia. We used high-performance liquid...
Information about the effects of phthalates and non-phthalate substitute cyclohexane-1,2-dicarboxylic acid diisononyl ester (HEXAMOLL® DINCH) on children's neurodevelopment is limited. The aim present research to evaluate association between phthalate/HEXAMOLL® DINCH exposure child in three European cohorts involved HBM4EU Aligned Studies. Participating subjects were school-aged children belonging Northern Adriatic cohort II (NAC-II), Italy, Odense Child Cohort (OCC), Denmark, PCB cohort,...
Phthalates represent endocrine disrupting chemicals, with harmful effect on the hormonal balance of human body.Food is a substantial source exposure to phthalates.The aim study was investigate association between phthalate children and their parents from Slovakia (children n = 51, 27) consumer practices.We analysed urine samples by high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) determine concentrations metabolites monoethyl (MEP), monomethyl (MMP), mono-n-buthyl...
The increasing number of human biomonitoring (HBM) studies undertaken in recent decades has brought to light the need harmonise procedures along all phases study, including sampling, data collection and analytical methods allow comparability. first steps towards harmonisation are identification collation HBM methodological information existing gaps. Systematic literature reviews meta-analyses have been traditionally put at top hierarchy evidence, being increasingly applied map available...
Di-2-ethylhexyl phthalate (DEHP) is a toxic and hazardous endocrine disruptor with adverse effects on animal human health. However, its impact bone tissue has not been sufficiently investigated. Therefore, the purpose of our preliminary study was to examine DEHP compact structure in two 57-days-old male mice. Daily oral administration (4.5 mg/kg body weight dissolved 500 µl peanut oil per 15 days) studied, compared control. We observed significant effect exposure macroscopic characteristics....
Di-2-ethylhexyl phthalate (DEHP) is a toxic and hazardous endocrine disruptor with adverse effects on animal human health. However, its impact bone tissue has not been sufficiently investigated. Therefore, the purpose of our preliminary study was to examine DEHP compact structure in two 57-days-old male mice. Daily oral administration (4.5 mg/kg body weight dissolved 500 µl peanut oil per 15 days) studied, compared control. We observed significant effect exposure macroscopic characteristics....