A5029824769- Metabolomics and Mass Spectrometry Studies
- Isotope Analysis in Ecology
- Mass Spectrometry Techniques and Applications
- Health, Environment, Cognitive Aging
- Toxic Organic Pollutants Impact
- Advanced Chemical Sensor Technologies
- Forensic and Genetic Research
- Effects and risks of endocrine disrupting chemicals
- Analytical chemistry methods development
- Environmental Toxicology and Ecotoxicology
- History and advancements in chemistry
- Chemistry and Chemical Engineering
- Pharmaceutical and Antibiotic Environmental Impacts
- Muscle activation and electromyography studies
- Computational Drug Discovery Methods
- Muscle Physiology and Disorders
- Biosensors and Analytical Detection
- Pesticide Residue Analysis and Safety
- Cancer, Lipids, and Metabolism
- Chemical Reactions and Isotopes
- Cancer, Hypoxia, and Metabolism
- Pesticide and Herbicide Environmental Studies
- Medical Imaging Techniques and Applications
- Pharmacological Effects and Assays
- Sports injuries and prevention
Vrije Universiteit Amsterdam
2015-2024
Utrecht University
2019-2023
Laboratoire D'étude des Résidus et Contaminants Dans les Aliments
2020
National Institute for Public Health and the Environment
2018
Manchester Metropolitan University
2015
Large-scale suspect and non-targeted screening approaches based on high-resolution mass spectrometry (HRMS) are today available for chemical profiling holistic characterisation of biological samples. These advanced techniques allow the simultaneous detection a large number features, including markers human exposure. Such interest biomonitoring, environmental health studies support to risk assessment. Furthermore, these have promising capability detect chemicals emerging concern (CECs),...
Abstract Background The NORMAN Association ( https://www.norman-network.com/ ) initiated the Suspect List Exchange (NORMAN-SLE; https://www.norman-network.com/nds/SLE/ in 2015, following collaborative trial on non-target screening of environmental water samples by mass spectrometry. Since then, this exchange information chemicals that are expected to occur environment, along with accompanying expert knowledge and references, has become a valuable base for “suspect screening” lists....
Abstract Increasing production and use of chemicals awareness their impact on ecosystems humans has led to large interest for broadening the knowledge chemical status environment human health by suspect non-target screening (NTS). To facilitate effective implementation NTS in scientific, commercial governmental laboratories, as well acceptance managers, regulators risk assessors, more harmonisation is required. address this, NORMAN Association members involved activities have prepared this...
The EU-EuroMix project adopted the strategy of European Food Safety Authority (EFSA) for cumulative risk assessment, which limits number chemicals to consider in a mixture those that induce specific toxicological phenotype. These so-called assessment groups (CAGs) are refined at several levels, including target organ and Here, we explore zebrafish embryo as test model quantitative evaluation one such CAG, skeletal malformations, through exposure compounds 0-120 hpf alcian blue cartilage...
Chemicals of Emerging Concern (CECs) include a very wide group chemicals that are suspected to be responsible for adverse effects on health, but which limited information is available. Chromatographic techniques coupled with high-resolution mass spectrometry (HRMS) can used non-targeted screening and detection CECs, by using comprehensive annotation databases. Establishing database focused the CECs in human samples will provide new insight into distribution extent exposures range humans.This...
Effect-directed analysis (EDA) aims at the detection of bioactive chemicals emerging concern (CECs) by combining toxicity testing and high-resolution mass spectrometry (HRMS). However, consolidation toxicological chemical techniques to identify CECs remains challenging laborious. In this study, we incorporate state-of-the-art identification approaches in EDA propose a robust workflow for high-throughput screening environmental human samples. Three different sample types were extracted...
What is the central question of this study? Do contractile properties single muscle fibres differ between body-builders, power athletes and control subjects? main finding its importance? Peak normalized for fibre volume in higher than subjects. Compared with subjects, maximal isometric tension (normalized cross-sectional area) lower body-builders. Although difference may be caused part by an apparent negative effect hypertrophy, these results indicate that training history increase quality,...
The chemical burden on the environment and human population is increasing. Consequently, regulatory risk assessment must keep pace to manage, reduce, prevent adverse impacts environmental health associated with hazardous chemicals. Surveillance of chemicals known, emerging, or potential future concern, entering environment-food-human continuum needed document reality risks posed by ecosystem from a one perspective, feed into early warning systems support public policies for exposure...
Abstract Non-target analysis (NTA) employing high-resolution mass spectrometry is a commonly applied approach for the detection of novel chemicals emerging concern in complex environmental samples. NTA typically results large and information-rich datasets that require computer aided (ideally automated) strategies their processing interpretation. Such do however raise challenge reproducibility between within different workflows. An effective strategy to mitigate such problems implementation...
This study aimed to identify antimicrobial contaminants in the aquatic environment with effect-directed analysis. Wastewater influent, effluent, and surface water (up- downstream of discharge location) were sampled at two sites. The samples enriched, subjected high-resolution fractionation, resulting 80 fractions tested an antibiotics bioassay. bioactive guided suspect nontargeted identification strategy mass spectrometry data that was recorded parallel. Chemical features annotated reference...
The muscle mass specific mean power output (PMMS,mean) during push-off in jumping is marmosets (Callithrix jacchus) more than twice that humans. In the present study it was tested whether this attributable to differences contractile properties. biopsies of marmoset m. vastus lateralis (VL) and gastrocnemius medialis (GM) (n=4) fiber type distribution assessed using fluorescent immunohistochemistry. single fibers from four nine human VL force-velocity characteristics were determined. Marmoset...
Effect-Directed Analysis (EDA) was used to identify bioactive compounds in surface and well water from the Upper Rhine, evaluate their properties against criteria set for Persistent, Mobile Toxic (PMT) very persistent mobile (vPvM) substances. A multi-layered solid-phase extraction implemented enrich a broad range of polar substances collected samples. The extracts were fractionated into 108 fractions tested transthyretin (TTR)-binding assay measuring displacement fluorescently labeled...
Abstract Background: The NORMAN Association (https://www.norman-network.com/) initiated the Suspect List Exchange (NORMAN-SLE; https://www.norman-network.com/nds/SLE/) in 2015, following collaborative trial on non-target screening of environmental water samples by mass spectrometry. Since then, this exchange information chemicals that are expected to occur environment, along with accompanying expert knowledge and references, has become a valuable base for “suspect screening” lists....
Dioxin(-like) exposures are linked to adverse health effects, including cancer. However, metabolic alterations induced by these chemicals remain largely unknown. Beyond known dioxin(-like) compounds, we leveraged a chemical-wide approach assess chlorinated co-exposures and parent compound products [termed dioxin(-like)-related compounds] among 137 occupational workers. Endogenous metabolites were profiled untargeted metabolomics, namely, reversed-phase chromatography with negative...
The possible risk that exposure to chemicals leads disruption of the thyroid hormone (TH) system in humans and animals can be assessed through biomonitoring for which TH has been demonstrated animal studies. In addition, epidemiological studies may establish a relationship between adverse outcomes on system. However, such are often limited single or classes chemicals, do not account complex mixtures exposed, consisting multiple combination affect similar different endpoints use vivo, vitro...
TPS 624: Exposures to pops, voc and other chemicals, Johan Friso Foyer, Floor 1, August 26, 2019, 3:00 PM - 4:30 As part of the HBM4EU project, a generic framework is proposed for detection annotation chemicals emerging concern (CECs) in human samples. This incorporates both suspect screening untargeted high-resolution mass spectrometry (HRMS) data effect-directed analysis (EDA). In order support EDA, comprehensive database CECs required. Advances HRMS techniques computational tools...