A5036137456- Pesticide Exposure and Toxicity
- Pesticide and Herbicide Environmental Studies
- Insect and Pesticide Research
- Pesticide Residue Analysis and Safety
- Environmental Toxicology and Ecotoxicology
- Analytical Chemistry and Chromatography
- Organophosphorus compounds synthesis
- Cultural Heritage Materials Analysis
- Toxic Organic Pollutants Impact
- Building materials and conservation
- Natural product bioactivities and synthesis
- Animal Ecology and Behavior Studies
- Free Radicals and Antioxidants
- Cholinesterase and Neurodegenerative Diseases
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Metabolomics and Mass Spectrometry Studies
- Conservation Techniques and Studies
- Synthesis and Biological Evaluation
- Sulfur Compounds in Biology
- Phytochemistry and Biological Activities
- Ginseng Biological Effects and Applications
- Acoustic Wave Resonator Technologies
- Medicinal Plants and Bioactive Compounds
- Flavonoids in Medical Research
- Pharmacological Effects of Natural Compounds
Vrije Universiteit Amsterdam
2023-2024
Lomonosov Moscow State University
2014-2023
Moscow State University
2020-2023
Division of Chemistry
2020
A sensitive screening method based on fast liquid chromatography tandem mass-spectrometry (RSLC–MS-MS) has shown the feasibility of separation and detection low concentration β-lyase metabolites sulfur mustard nerve agent phosphonic acids in urine. The analysis these compounds is interest because they are specific chemical warfare agents (CWAs), (HD), sarin (GB), soman (GD), VX Russian (RVX). ‘dilute-and-shoot’ RSLC–MS-MS provides a direct approach for determining CWA exposure non-extracted...
Superoxide is the primary active oxygen form produced in living organisms. Because of superoxide anion radical formation during epinephrine oxidation alkaline medium, this system offered some works for antioxidant activity analysis, however, without enough physicochemical justification. Therefore, task developing reliable methods analyzing inhibition various objects very urgent. In work, a kinetic model autoxidation an medium presence antioxidants plant origin proposed. The participation...
Persistent, mobile, and toxic compounds released to the environment are likely pollute drinking water sources due their slow environmental degradation (persistency) high solubility (mobility). The aim of present study was create in vitro hazard profiles for 16 triazoles, 9 triazines, 11 poly- perfluoroalkyl substances (PFAS) based on agonistic antagonistic effects estrogen receptor (ER), androgen (AR), thyroid hormone (TR) reporter gene assays, ability bind human transthyretin (TTR),...
Effect-Directed Analysis (EDA) was used to identify bioactive compounds in surface and well water from the Upper Rhine, evaluate their properties against criteria set for Persistent, Mobile Toxic (PMT) very persistent mobile (vPvM) substances. A multi-layered solid-phase extraction implemented enrich a broad range of polar substances collected samples. The extracts were fractionated into 108 fractions tested transthyretin (TTR)-binding assay measuring displacement fluorescently labeled...
Radiolytic stability is one of the main requirements substances that are used in chemistry nuclear cycle or radiopharmaceutical chemistry. Herein, we proposed an approach for prediction radiolytic by estimation molecular reactivity. The DFT calculations atom-wise reactivity descriptor were made a number organic molecules. theoretical simulations validated experimental data. We irradiated molecules gamma-radiation and studied products radiolysis changes concentration HPLC-MS analysis....
The data processing workflow for LC-MS based metabolomics study is suggested with signal drift correction, univariate analysis, supervised learning, feature selection and unsupervised modelling.
A new sensitive rapid-separation liquid chromatography tandem mass spectrometry approach for the determination of thiodiglycolic acid (TDGA) in urine has been developed. The use "dilute-and-shoot" method helps to shorten sample preparation stage and provides a direct TDGA urine. Chromatographic separation analyte other compounds was achieved using reverse-phase column with mobile phases consisting 0.1% formic water acetonitrile gradient elution mode. For identification quantification...
Abstract In this paper a summary of the author’s approaches for investigation mass spectral behavior some chemical warfare agents (CWAs), their degradation products and metabolites, as well results development analytical methods confirmation nerve blister application are presented. Hydrolysis oxidation metabolites agents, sulfur mustard lewisite were used biomarkers exposure. Sensitive have been developed detection, based mainly on tandem spectrometry coupled with liquid chromatography....
Evaluation of safety, quality and composition herbal products food supplements based on botanical ingredients is a matter serious concern. For screening botanicals in multitargeted group-targeted approaches may be applied. In the approach are characterized by means an appropriate group structurally related biomarkers compared with where number selected analytes monitored multiple reaction monitoring survey. this study unified strategy for control was developed basis fast ultrasound-assisted...