A5009428576- Analytical Chemistry and Chromatography
- Microfluidic and Capillary Electrophoresis Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Mass Spectrometry Techniques and Applications
- Analytical chemistry methods development
- Analytical Methods in Pharmaceuticals
- Chemical Synthesis and Analysis
- Advanced Chemical Sensor Technologies
- Chemical Reactions and Isotopes
- Pesticide Residue Analysis and Safety
- Molecular spectroscopy and chirality
- Porphyrin and Phthalocyanine Chemistry
- Protein purification and stability
- Electrochemical Analysis and Applications
- Amino Acid Enzymes and Metabolism
- Polyoxometalates: Synthesis and Applications
- Molecular Sensors and Ion Detection
- Crystallization and Solubility Studies
- Embedded Systems and FPGA Design
- Water Quality Monitoring and Analysis
- Iron oxide chemistry and applications
- Chemical Synthesis and Characterization
- Synthesis and Biological Evaluation
- Antibiotics Pharmacokinetics and Efficacy
- Electrowetting and Microfluidic Technologies
Lomonosov Moscow State University
2011-2020
Samsung (Russia)
2020
Moscow State University
2004-2013
The first use of macrolide antibiotic clarithromycin (CLM) in nonaqueous media for enantioseparation (partial or baseline) the following compounds: alprenolol, atenolol, metoprolol, clenbuterol, methoxyphenamine, pindolol, propranolol, sotalol, synephrine, labetalol, and fenoterol is reported. Each analysis took less than 15 min. To find optimal separation conditions, some properties CLM (adsorption, solubility), as well effect experimental parameters on analytes (background electrolyte...
The review surveys data on the use of cyclodextrins as chiral selectors in high-performance liquid chromatography and capillary electrophoresis. mechanisms enantiomer separation factors influencing selectivity efficiency various methods electrophoresis are considered. Numerous examples practical application optical isomers given. bibliography includes 325 references.
A new silica-based, mixed-binary chiral sorbent grafted with the macrocyclic antibiotic eremomycin and bovine serum albumin (BSA) was obtained. The sorbent-filled high-performance liquid chromatography column capable of enantioseparation racemic drugs, such as profens, in reversed-phase-chromatography mode. eremomycin-BSA-sorbent showed better capability for profens compared a containing only. BSA onto surface significantly reduced retention times other proteins from analyte solution, free...
Abstract A hepta‐substituted β‐cyclodextrin bearing seven amino groups, heptakis(6‐amino‐6‐deoxy)‐β‐cyclodextrin (per‐6‐NH 2 ‐β‐CD) was successfully used as a chiral selector for the enantioseparation of different anionic analytes. The running buffer pH and concentration were studied parameters crucial in achieving maximum possible enantioresolution. Enantiomeric separation mixture carboxybenzyl‐amino acids achieved 24 min. Excellent resolution obtained carboxybenzyl‐tryptophan ( R s = 11.2).
The adsorption of macrocyclic antibiotic eremomycin on the capillary wall has been studied and concentration EOF reversion determined. combination coupled chitosan coating as run buffer additive proposed for chiral separation. advantages (time analysis efficiency) chitosan-coated over fused-silica have shown. effect experimental parameters, influencing enantioseparation, investigated. Carboxylic acids bearing α-C*-asymmetric carbon atom (ibuprofen, indoprofen, ketoprofen, fenoprofen,...
Abstract Strong adsorption of eremomycin on the fused‐silica capillary wall was used for separation enantiomers by CE. The with adsorbed chiral selector shown to be easily prepared and has reproducible properties. effect concentration, pH composition BGE, applied voltage enantioseparation acidic compounds, such as profens aromatic carboxylic acids, investigated. Two native α‐amino aspartic acid glutamic acid, were enantioseparated. Fourteen tested compounds (including amino acids) baseline...
Synthesis of new polycation-stabilized gold nanoparticles was performed by the borohydride approach. 6,6-ionene used as a polycationic stabilizer. The influence several factors such acidity, Au:ionene ratio and concentration sodium during synthesis were investigated. key role amount HCl added on behaviour products in time shown. Optimal conditions for chosen. prepared characterized surface plasmon resonance band at 520 nm. Their average diameter is 16 Apart from spherical (73%), there...
Two silica capillaries modified layer-by-layer with 6,10-ionene and N-(3-sulfo-3-carboxy)-propionylchitosan (SCPC) dextran sulfate (DS) were prepared investigated. Dynamic coating of the capillary efficiently reduces adsorption background electrolyte, sample matrix components, analytes on its inner wall. Such coatings effect good reproducibility sensitivity determination. We demonstrate that separation betablockers, calcium channel blockers, alpha-adrenergic agonists, H 1 -blockers,...