Evan Bolton
A5015494748- Computational Drug Discovery Methods
- Health, Environment, Cognitive Aging
- Metabolomics and Mass Spectrometry Studies
- Biomedical Text Mining and Ontologies
- Analytical Chemistry and Chromatography
- Various Chemistry Research Topics
- Radioactive element chemistry and processing
- History and advancements in chemistry
- Chemical Reactions and Isotopes
- Genomics and Phylogenetic Studies
- Genetics, Bioinformatics, and Biomedical Research
- Semantic Web and Ontologies
- Machine Learning in Materials Science
- Scientific Computing and Data Management
- Inorganic and Organometallic Chemistry
- Glycosylation and Glycoproteins Research
- Bioinformatics and Genomic Networks
- Single-cell and spatial transcriptomics
- Mass Spectrometry Techniques and Applications
- Carbohydrate Chemistry and Synthesis
- Advanced Chemical Sensor Technologies
- Microbial Natural Products and Biosynthesis
- Chemistry and Chemical Engineering
- Research Data Management Practices
- Chemical Thermodynamics and Molecular Structure
National Institutes of Health
2015-2025
National Center for Biotechnology Information
2015-2025
United States National Library of Medicine
2015-2023
ORCID
2021
Medical University of Graz
2009-2011
University of Georgia
1992-1997
PubChem (https://pubchem.ncbi.nlm.nih.gov) is a public repository for information on chemical substances and their biological activities, launched in 2004 as component of the Molecular Libraries Roadmap Initiatives US National Institutes Health (NIH). For past 11 years, has grown to sizable system, serving resource scientific research community. consists three inter-linked databases, Substance, Compound BioAssay. The Substance database contains deposited by individual data contributors...
PubChem (https://pubchem.ncbi.nlm.nih.gov) is a popular chemical information resource that serves the scientific community as well general public, with millions of unique users per month. In past two years, made substantial improvements. Data from more than 100 new data sources were added to PubChem, including chemical-literature links Thieme Chemistry, and physical property SpringerMaterials, patent World Intellectual Properties Organization (WIPO). PubChem's homepage individual record...
PubChem (https://pubchem.ncbi.nlm.nih.gov) is a key chemical information resource for the biomedical research community. Substantial improvements were made in past few years. New data content was added, including spectral information, scientific articles mentioning chemicals, and food agricultural chemicals. released new web interfaces, such as Target View page, Sources Bioactivity dyad pages Patent page. also major update to Widgets introduced programmatic access interface, called PUG-View....
Abstract The National Center for Biotechnology Information (NCBI) produces a variety of online information resources biology, including the GenBank® nucleic acid sequence database and PubMed® citations abstracts published in life science journals. NCBI provides search retrieval operations most these data from 35 distinct databases. E-utilities serve as programming interface Resources receiving significant updates past year include PubMed, PMC, Bookshelf, RefSeq, SRA, Virus, dbSNP, dbVar,...
Abstract PubChem (https://pubchem.ncbi.nlm.nih.gov) is a popular chemical information resource that serves wide range of use cases. In the past two years, number changes were made to PubChem. Data from more than 120 data sources was added Some major highlights include: integration Google Patents into PubChem, which greatly expanded coverage Patent collection; creation Cell Line and Taxonomy collections, provide quick easy access for given cell line taxon, respectively; update bioassay model....
The National Center for Biotechnology Information (NCBI) provides a large suite of online resources biological information and data, including the GenBank® nucleic acid sequence database PubMed citations abstracts published life science journals. Entrez system search retrieval operations most these data from 39 distinct databases. E-utilities serve as programming interface system. Augmenting many Web applications are custom implementations BLAST program optimized to specialized sets. New...
Scientists have long been driven by the desire to describe, organize, classify, and compare objects using taxonomies and/or ontologies. In contrast biology, geology, many other scientific disciplines, world of chemistry still lacks a standardized chemical ontology or taxonomy. Several attempts at classification made; but they mostly limited either manual, semi-automated proof-of-principle applications. This is regrettable as comprehensive description tools could not only improve our...
Author(s): Varki, Ajit; Cummings, Richard D; Aebi, Markus; Packer, Nicole H; Seeberger, Peter Esko, Jeffrey Stanley, Pamela; Hart, Gerald; Darvill, Alan; Kinoshita, Taroh; Prestegard, James J; Schnaar, Ronald L; Freeze, Hudson Marth, Jamey Bertozzi, Carolyn R; Etzler, Marilynn E; Frank, Martin; Vliegenthart, Johannes Fg; Lutteke, Thomas; Perez, Serge; Bolton, Evan; Rudd, Pauline; Paulson, James; Kanehisa, Minoru; Toukach, Philip; Aoki-Kinoshita, Kiyoko F; Dell, Anne; Narimatsu, Hisashi;...
In addition to maintaining the GenBank® nucleic acid sequence database, National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources data in GenBank other biological made available through NCBI Web site. include Entrez, Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central (PMC), Gene, Taxonomy Browser, BLAST, BLAST Link (BLink), Primer-BLAST, COBALT, Electronic PCR, OrfFinder, Splign, ProSplign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP,...
The current version of the Human Disease Ontology (DO) (http://www.disease-ontology.org) database expands utility ontology for examination and comparison genetic variation, phenotype, protein, drug epitope data through lens human disease. DO is a biomedical resource standardized common rare disease concepts with stable identifiers organized by etiology. content has had 192 revisions since 2012, including addition 760 terms. Thirty-two percent all terms now include definitions. expanded...
PubChem (http://pubchem.ncbi.nlm.nih.gov) is a public repository for biological activity data of small molecules and RNAi reagents. The mission to deliver free easy access all deposited data, provide intuitive analysis tools. BioAssay database currently contains 500 000 descriptions assay protocols, covering 5000 protein targets, 30 gene targets providing over 130 million bioactivity outcomes. PubChem's bioassay are integrated into the NCBI Entrez information retrieval system, thus making...
In addition to maintaining the GenBank® nucleic acid sequence database, National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources data in GenBank other biological made available through NCBI web site. include Entrez, Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central, Gene, Taxonomy Browser, BLAST, BLAST Link (BLink), Electronic PCR, OrfFinder, Spidey, Splign, Reference Sequence, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes,...
In addition to maintaining the GenBank® nucleic acid sequence database, National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources data in GenBank other biological made available through NCBI Website. include Entrez, Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central (PMC), Gene, Taxonomy Browser, BLAST, BLAST Link (BLink), Primer-BLAST, COBALT, Splign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, dbVar, Epigenomics, Genome related tools,...
The National Center for Biotechnology Information (NCBI) provides a large suite of online resources biological information and data, including the GenBank® nucleic acid sequence database PubMed citations abstracts published in life science journals. Entrez system search retrieval operations most these data from 38 distinct databases. E-utilities serve as programming interface system. Augmenting many web applications are custom implementations BLAST program optimized to specialized sets. New...
The National Center for Biotechnology Information (NCBI) provides a large suite of online resources biological information and data, including the GenBank® nucleic acid sequence database PubMed citations abstracts published in life science journals. Entrez system search retrieval operations most these data from 35 distinct databases. E-utilities serve as programming interface system. Custom implementations BLAST program provide sequence-based searching many specialized datasets. New released...
Abstract The Symbol Nomenclature for Glycans (SNFG) is a community-curated standard the depiction of monosaccharides and complex glycans using various colored-coded, geometric shapes, along with defined text additions. It hosted by National Center Biotechnology Information (NCBI) at NCBI-Glycans Page (www.ncbi.nlm.nih.gov/glycans/snfg.html). Several changes have been made to SNFG page in past year update rules depicting SNFG, include more examples use, particularly non-mammalian organisms,...
The National Center for Biotechnology Information (NCBI) provides online information resources biology, including the GenBank® nucleic acid sequence database and PubMed® of citations abstracts published in life science journals. NCBI search retrieval operations most these data from 35 distinct databases. E-utilities serve as programming interface New include Comparative Genome Resource (CGR) BLAST ClusteredNR database. Resources receiving significant updates past year PubMed, PMC, Bookshelf,...
The PubChem BioAssay database (http://pubchem.ncbi.nlm.nih.gov) is a public repository for biological activities of small molecules and interfering RNAs (siRNAs) hosted by the US National Institutes Health (NIH). It archives experimental descriptions assays test results makes information freely accessible to public. A data entry includes an assay description, summary detailed results. Each record linked molecular target, whenever possible, cross-referenced other Center Biotechnology...
Abstract The National Center for Biotechnology Information (NCBI) provides online information resources biology, including the GenBank® nucleic acid sequence database and PubMed® of citations abstracts published in life science journals. NCBI search retrieval operations most these data from 35 distinct databases. E-utilities serve as programming interface Resources receiving significant updates past year include PubMed, PMC, Bookshelf, SciENcv, NIH Comparative Genomics Resource (CGR), Virus,...
Abstract Background The NORMAN Association ( https://www.norman-network.com/ ) initiated the Suspect List Exchange (NORMAN-SLE; https://www.norman-network.com/nds/SLE/ in 2015, following collaborative trial on non-target screening of environmental water samples by mass spectrometry. Since then, this exchange information chemicals that are expected to occur environment, along with accompanying expert knowledge and references, has become a valuable base for “suspect screening” lists....
Per- and polyfluoroalkyl substances (PFAS) are of high concern, with calls to regulate them as a class. In 2021, the Organisation for Economic Co-operation Development (OECD) revised definition PFAS include any chemical containing at least one saturated CF2 or CF3 moiety. The consequence is that largest open collections, PubChem, 116 million compounds, now contains over 7 under this definition. These numbers several orders magnitude higher than previously established lists (typically...
Knowledge about the 3-dimensional structure, orientation and interaction of chemical compounds is important in many areas science technology. X-ray crystallography one experimental techniques capable providing a large amount structural information for given compound, it widely used characterisation organic metal-organic molecules. The method provides precise 3D coordinates atoms inside crystals, however, does not directly deliver certain characteristics such as bond orders, delocalization,...
Abstract PubChem (https://pubchem.ncbi.nlm.nih.gov) is a large and highly-integrated public chemical database resource at NIH. In the past two years, significant updates were made to PubChem. With additions from over 130 new sources, contains >1000 data 119 million compounds, 322 substances 295 bioactivities. New interfaces, such as consolidated literature panel patent knowledge panel, developed. The combines all references about compound into single list, allowing users easily find,...