A5004083401- Anatomy and Medical Technology
- Surgical Simulation and Training
- Biomedical Text Mining and Ontologies
- Computational Drug Discovery Methods
- Advanced X-ray and CT Imaging
- Free Radicals and Antioxidants
- Artificial Intelligence in Healthcare and Education
- Radiomics and Machine Learning in Medical Imaging
- Bioinformatics and Genomic Networks
- Digital Imaging in Medicine
- Genomics, phytochemicals, and oxidative stress
- Biomedical and Engineering Education
- Semantic Web and Ontologies
- Radiology practices and education
- Esophageal and GI Pathology
- Aortic aneurysm repair treatments
- Orthopaedic implants and arthroplasty
- Cardiac, Anesthesia and Surgical Outcomes
- Radiation Dose and Imaging
- Lung Cancer Diagnosis and Treatment
- Analytical Chemistry and Chromatography
- 3D Printing in Biomedical Research
- Scientific Computing and Data Management
- COVID-19 diagnosis using AI
- Breast Implant and Reconstruction
University of Toronto
2022-2024
University Health Network
2022-2024
Toronto General Hospital
2023
Stanford University
2021-2022
Carleton University
2004-2022
University of Ottawa
2003-2022
University of Cincinnati Medical Center
2022
Ottawa Hospital
2015-2019
Library and Archives Canada
2011
Ottawa Institute of Systems Biology
2008
Scientists have long been driven by the desire to describe, organize, classify, and compare objects using taxonomies and/or ontologies. In contrast biology, geology, many other scientific disciplines, world of chemistry still lacks a standardized chemical ontology or taxonomy. Several attempts at classification made; but they mostly limited either manual, semi-automated proof-of-principle applications. This is regrettable as comprehensive description tools could not only improve our...
The Semanticscience Integrated Ontology (SIO) is an ontology to facilitate biomedical knowledge discovery. SIO features a simple upper level comprised of essential types and relations for the rich description arbitrary (real, hypothesized, virtual, fictional) objects, processes their attributes. specifies design patterns describe associate qualities, capabilities, functions, quantities, informational entities including textual, geometrical, mathematical entities, provides specific extensions...
Medical three-dimensional (3D) printing has expanded dramatically over the past three decades with growth in both facility adoption and variety of medical applications. Consideration for each step required to create accurate 3D printed models from imaging data impacts patient care management. In this paper, a writing group representing Radiological Society North America Special Interest Group on Printing (SIG) provides recommendations that have been vetted voted by SIG active membership....
Abstract Purpose To propose a new quality scoring tool, METhodological RadiomICs Score (METRICS), to assess and improve research of radiomics studies. Methods We conducted an online modified Delphi study with group international experts. It was performed in three consecutive stages: Stage#1, item preparation; Stage#2, panel discussion among EuSoMII Auditing Group members identify the items be voted; Stage#3, four rounds exercise by panelists determine eligible for METRICS their weights. The...
Cheminformatics is the application of informatics techniques to solve chemical problems in silico. There are many areas biology where cheminformatics plays an important role computational research, including metabolism, proteomics, and systems biology. One critical aspect these fields accurate exchange data, which increasingly accomplished through use ontologies. Ontologies formal representations objects their properties using a logic-based ontology language. Many such ontologies currently...
We are attempting to develop novel synthetic antioxidants aimed at retarding the effects of free-radical induced cell damage. In this paper we discuss design strategy and report synthesis seven antioxidants, including six catechols a benzylic phenol. The bond dissociation enthalpy (BDE) for most active (weakest) OH in each molecule was calculated by theoretical methods, as well BDE semiquinone radical. Reaction rates with nitrogen-centered free radical DPPH• were measured ethyl acetate. log...
In this paper we examine a series of hydrocarbons with structural features which cause weakening the C-H bond. We use theoretical calculations to explore whether carbon-centered radicals R(*) are created after breaking bond can be stabilized enough so that they resist addition molecular oxygen, i.e. where reaction + O(2) --> ROO(*) becomes energetically unfavorable. Calculations using B3LYP-based method provide accurate dissociation enthalpies (BDEs) for R-H and R-OO(*) bonds, as well Gibbs...
Hand-held three dimensional models of the human anatomy and pathology, tailored-made protheses, custom-designed implants can be derived from imaging modalities, most commonly Computed Tomography (CT). However, standard DICOM format images cannot 3D printed; instead, additional image post-processing is required to transform interest into Standard Tessellation Language (STL) needed. This conversion, subsequent printing STL file, requires a series steps. Initial involves...
The paper describes a density functional theory methodology using the B3LYP functional, with small correction terms introduced for open shell doublet states and closed-shell anions. procedure is based on B3LYP/6-31G(d) geometry optimization frequency determination, followed by (RO)B3LYP/6-311 + G(2d,2p) single point energy calculations. Using term of +8.368 kJ mol−1 (doublet) radicals 4.184 (closed shell) anions, close agreement obtained experiment (i.e. within 10 mol−1) series molecular...
Bisphenol A (BPA) is used in the production of polycarbonate plastics and epoxy resins for baby bottles, liners canned food, many other consumer products. Previously, BPA has been shown to reduce activity several antioxidant enzymes, which may contribute oxidative stress. However, underlying mechanism BPA-mediated effect upon enzyme unknown. Antioxidant phase II metabolizing enzymes protect cells from stress are transcriptionally activated by Nrf1 Nrf2 factors through their cis-regulatory...
Medical 3D printing is expanding exponentially, with tremendous potential yet to be realized in nearly all facets of medicine. Unfortunately, multiple informal subdomain-specific isolated terminological 'silos' where disparate terminology used for similar concepts are also arising as rapidly. It imperative formalize the foundational at this early stage facilitate future knowledge integration, collaborative research, and appropriate reimbursement. The purpose work develop objective,...
Purpose The dimensional accuracy of three‐dimensional (3D) printed anatomical models is essential to correctly understand spatial relationships and enable safe presurgical planning. Most recent studies focused on 3D printing a single pathology for surgical This study evaluated the medical across multiple pathologies, using desktop inverted vat photopolymerization (VP) print anatomic both rigid elastic materials. Methods In primary study, we seven (six one reference cube) with volumes ranging...
Medical 3D printing has demonstrated value in anatomic models for abdominal, hepatobiliary, and gastrointestinal conditions. A writing group composed of the Radiological Society North America (RSNA) Special Interest Group on Printing (SIG) provides appropriateness criteria indications.A literature search was conducted to identify all relevant articles using technology associated with a number abdominal pathologic processes. Each included study graded according published...
Rate constants for hydrogen-atom transfer (HAT) from bilirubin dimethyl ester (BRDE) and biliverdin (BVDE) to peroxyl radicals during inhibited autoxidation of styrene initiated by azo-bisisobutyronitrile (AIBN) were kinh(BRDE) = 22.5 × 104 kinh(BVDE) 10.2 M-1 s-1, the stoichiometric factors (n) 2.0 2.7, respectively. A synthetic tetrapyrrole (bis(dipyrromethene)) containing α-central (2,2') CH2 linkage gave kinh 39.9 s-1 n 2.3, whereas β-linked (3,3') isomer was not an active antioxidant....
The anti-tumour activities of many plant phenolics at high concentrations (>100 μmol/L) suggest their potential use as dietary supplements in cancer chemoprevention and chemotherapy. However, it is not clear what impact phenolic compounds have the physiological obtained through consumption diets on neoplastic cells. In present study, 54 naturally occurring were evaluated physiologically relevant for capacity to alter PC12 cell viability response serum deprivation, chemotherepeutic agent...