A5041976538- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Medical Imaging and Pathology Studies
- HER2/EGFR in Cancer Research
- Pancreatic and Hepatic Oncology Research
- Phagocytosis and Immune Regulation
- Lung Cancer Treatments and Mutations
- Tuberous Sclerosis Complex Research
- Estrogen and related hormone effects
- Neuroendocrine Tumor Research Advances
- Pesticide Exposure and Toxicity
- Monoclonal and Polyclonal Antibodies Research
- Cancer Mechanisms and Therapy
- Radiomics and Machine Learning in Medical Imaging
- Inflammatory mediators and NSAID effects
- Amino Acid Enzymes and Metabolism
- Chemical Reactions and Isotopes
- Glycosylation and Glycoproteins Research
- Chronic Myeloid Leukemia Treatments
- Nanoplatforms for cancer theranostics
- Pesticide and Herbicide Environmental Studies
- Cancer Treatment and Pharmacology
- RNA modifications and cancer
- Advanced MRI Techniques and Applications
Shonan Kamakura General Hospital
2022-2024
Minzu University of China
2024
Chonnam National University
2024
Himax (Taiwan)
2024
AGH University of Krakow
2024
University of Applied Sciences and Arts of Southern Switzerland
2024
The University of Texas MD Anderson Cancer Center
2006-2023
Duke University
2023
University of Oxford
2023
Beijing Glass Research Institute
2023
To develop a hydrophilic ligand to image tumor hypoxia at positron emission tomography (PET).Biodistribution of fluorine-18-labeled fluoroerythronitroimidazole (FETNIM) and F-18-labeled fluoromisonidazole (FMISO) was determined PET autoradiography in three mammary-tumor-bearing rats. The partition coefficient FETNIM, FMISO, misonidazole determined.Biodistribution FETNIM 1, 2, 4 hours showed tumor-to-blood ratios 2.29 +/- 0.599, 2.41 0.567 8.02 2.420, respectively, tumor-to-muscle 0.66 0.267,...
Positron emission tomography (PET) with fluorine-18 fluorodeoxyglucose (FDG) was used to differentiate recurrent or residual malignant disease from the effects of cancer treatment. Transaxial images were obtained after injection 5-10 mCi (185-370 MBq) F-18 FDG in 68 patients (including 33 brain tumors) whose posttreatment computed tomographic (CT) magnetic resonance (MR) imaging findings had been suggestive disease. PET correlated surgical results 18 and outcomes CT, MR imaging, clinical,...
PURPOSE: To evaluate the feasibility of technetium 99m (99mTc) ethylenedicysteine–deoxyglucose (ECDG) imaging in tumor-bearing rodents. MATERIALS AND METHODS: ECDG was synthesized by means reacting ethylenedicysteine with glucosamine, carbodiimide as coupling agent. Hexokinase assays were performed at an ultraviolet wavelength 340 nm. determine whether blood glucose level could be altered, or glucosamine injected into six rats. In a separate study, followed insulin administered to three...
PET Chemistry: The Driving Force in Molecular Imaging describes the development of radiochemicals as concepts move from bench work to clinical products. targets have been applied tools for personalized medicine areas disease imaging, therapy assessment, selection patients
The appearance of myocardial scars often signals the aggravation and deterioration cardiovascular diseases. Accurate phenotyping scarred myocardium is critically important for personalized diagnosis treatment patients with However, existing methods can not effectively capture cardiac motion texture dependencies, resulting in insufficient performance. In this paper, we propose a novel dual-branch deep learning method non-contrast enhanced MR images, by jointly modeling contexts. For branch,...
Objective: The purpose of this study was to develop an imaging technique measure and monitor tumor cells undergoing programmed death caused by radiation chemotherapy using 99mTc-EC-annexin V. Annexin V has been used cell both in vitro vivo. Assessment apoptosis would be useful evaluate the efficacy mechanisms therapy disease progression or regression. Methods: Ethylenedicysteine (EC) conjugated annexin sulfo-N-hydroxysuccinimide 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide-HCl as coupling...
Water-soluble paclitaxel may cause less side effects and be costly to administer In comparison a taxol formulation using cremophor EL/alcohol vehicle. this study, polyethylene glycol (PEG; MW 5000) was conjugated the 2' position of through spacer succlnyl group. PEG as non-Ionic prodrug highly water soluble (>20 mg equlv. paclitaxel/ml). The release from phosphate-buffered solution pH dependent. half-life 7.6, 54 311 min at 9.0, 7.4 6.0, respectively. inhibited growth B16 melanoma cells an...
To diagnose cancers with radiolabelled amino acid using positron emission tomography, we have constructed a separation and purification system for the production of L-18F-α-methyltyrosine (L-18FAmT). This could provide radioprotection consistent L-18FAmT. L-18FAmT was synthesized purified efficiency examined. The radiochemical yield 20.3 ± 5.1% (n = 5) based on radioactivity trapped in reaction vessel. purity greater than 99.4 0.3% 5). stability phosphate-buffered saline human plasma...
Fava beans (Vicia faba) upon treatment with nitrite under simulated gastric conditions, form a direct-acting bacterial mutagen, comparable in specific activity to the most potent known mutagens for several strains of Salmonella typhimurium. The precursor mutagen was isolated and identified as 4-chloro-6-methoxyindole by u.v., i.r., m.s. n.m.r. dechlorinated NaBH4 PdCl2 catalyst product obtained from this reaction 6-methoxyindole. Since synthetic not available, structure studies were...
We conducted a two-phase trial in which 100-micron polylactic acid microcapsules with cisplatin payload (manufactured at our institution [the M. D. Anderson Cancer Center]) were used for hepatic artery occlusion therapy symptomatic patients who had liver metastases from neuroendocrine tumors.Between January 1993 and December 1995, 20 advanced, unresectable, tumors received repeated using encapsulated cisplatin. The dose of was increased stepwise fashion. Selective angiography to occlude the...