A5100430147- Computational Drug Discovery Methods
- Electrical and Bioimpedance Tomography
- Metabolomics and Mass Spectrometry Studies
- Corporate Finance and Governance
- Advanced Chemical Physics Studies
- Biomedical Text Mining and Ontologies
- Photochemistry and Electron Transfer Studies
- Various Chemistry Research Topics
- Genetics, Bioinformatics, and Biomedical Research
- Microwave Imaging and Scattering Analysis
- Numerical methods in inverse problems
- Genomics and Phylogenetic Studies
- Technology and Data Analysis
- Analytical Chemistry and Chromatography
- Flow Measurement and Analysis
- Advanced Malware Detection Techniques
- Non-Destructive Testing Techniques
- DNA and Nucleic Acid Chemistry
- Complex Network Analysis Techniques
- Geophysical and Geoelectrical Methods
- User Authentication and Security Systems
- History and advancements in chemistry
- Inorganic and Organometallic Chemistry
- Working Capital and Financial Performance
- Chemistry and Chemical Engineering
National Center for Biotechnology Information
2015-2025
National Institutes of Health
2016-2025
Jeonju University
2024
Semyung University
2024
Sandia National Laboratories California
2008-2024
Pukyong National University
2024
Hanyang University
2002-2023
Seoul National University
2010-2023
United States National Library of Medicine
2023
Korea Institute of Toxicology
2018-2022
PubChem (https://pubchem.ncbi.nlm.nih.gov) is a public repository for information on chemical substances and their biological activities, launched in 2004 as component of the Molecular Libraries Roadmap Initiatives US National Institutes Health (NIH). For past 11 years, has grown to sizable system, serving resource scientific research community. consists three inter-linked databases, Substance, Compound BioAssay. The Substance database contains deposited by individual data contributors...
PubChem (https://pubchem.ncbi.nlm.nih.gov) is a popular chemical information resource that serves the scientific community as well general public, with millions of unique users per month. In past two years, made substantial improvements. Data from more than 100 new data sources were added to PubChem, including chemical-literature links Thieme Chemistry, and physical property SpringerMaterials, patent World Intellectual Properties Organization (WIPO). PubChem's homepage individual record...
PubChem (https://pubchem.ncbi.nlm.nih.gov) is a key chemical information resource for the biomedical research community. Substantial improvements were made in past few years. New data content was added, including spectral information, scientific articles mentioning chemicals, and food agricultural chemicals. released new web interfaces, such as Target View page, Sources Bioactivity dyad pages Patent page. also major update to Widgets introduced programmatic access interface, called PUG-View....
Abstract The National Center for Biotechnology Information (NCBI) produces a variety of online information resources biology, including the GenBank® nucleic acid sequence database and PubMed® citations abstracts published in life science journals. NCBI provides search retrieval operations most these data from 35 distinct databases. E-utilities serve as programming interface Resources receiving significant updates past year include PubMed, PMC, Bookshelf, RefSeq, SRA, Virus, dbSNP, dbVar,...
Abstract PubChem (https://pubchem.ncbi.nlm.nih.gov) is a popular chemical information resource that serves wide range of use cases. In the past two years, number changes were made to PubChem. Data from more than 120 data sources was added Some major highlights include: integration Google Patents into PubChem, which greatly expanded coverage Patent collection; creation Cell Line and Taxonomy collections, provide quick easy access for given cell line taxon, respectively; update bioassay model....
The National Center for Biotechnology Information (NCBI) provides a large suite of online resources biological information and data, including the GenBank® nucleic acid sequence database PubMed citations abstracts published in life science journals. Entrez system search retrieval operations most these data from 38 distinct databases. E-utilities serve as programming interface system. Augmenting many web applications are custom implementations BLAST program optimized to specialized sets. New...
The National Center for Biotechnology Information (NCBI) provides a large suite of online resources biological information and data, including the GenBank® nucleic acid sequence database PubMed citations abstracts published in life science journals. Entrez system search retrieval operations most these data from 35 distinct databases. E-utilities serve as programming interface system. Custom implementations BLAST program provide sequence-based searching many specialized datasets. New released...
The National Center for Biotechnology Information (NCBI) provides online information resources biology, including the GenBank® nucleic acid sequence database and PubMed® of citations abstracts published in life science journals. NCBI search retrieval operations most these data from 35 distinct databases. E-utilities serve as programming interface New include Comparative Genome Resource (CGR) BLAST ClusteredNR database. Resources receiving significant updates past year PubMed, PMC, Bookshelf,...
Abstract The National Center for Biotechnology Information (NCBI) provides online information resources biology, including the GenBank® nucleic acid sequence database and PubMed® of citations abstracts published in life science journals. NCBI search retrieval operations most these data from 35 distinct databases. E-utilities serve as programming interface Resources receiving significant updates past year include PubMed, PMC, Bookshelf, SciENcv, NIH Comparative Genomics Resource (CGR), Virus,...
The National Center for Biotechnology Information (NCBI) provides online information resources biology, including the GenBank® nucleic acid sequence repository and PubMed® of citations abstracts published in life science journals. NCBI search retrieval operations most these data from 31 distinct repositories knowledgebases. E-utilities serve as programming interface these. Resources receiving significant updates past year include PubMed, PubMed Central, Bookshelf, NIH Comparative Genomics...
Abstract PubChem (https://pubchem.ncbi.nlm.nih.gov) is a large and highly-integrated public chemical database resource at NIH. In the past two years, significant updates were made to PubChem. With additions from over 130 new sources, contains >1000 data 119 million compounds, 322 substances 295 bioactivities. New interfaces, such as consolidated literature panel patent knowledge panel, developed. The combines all references about compound into single list, allowing users easily find,...
Finding relevant chemicals in the vast (known) chemical space is a major challenge for environmental and exposomics studies leveraging nontarget high resolution mass spectrometry (NT-HRMS) methods. Chemical databases now contain hundreds of millions chemicals, yet many are not relevant. This article details an extensive collaborative, open science effort to provide dynamic collection environmental, metabolomics, research, along with supporting information about their relevance assist...
PubChem is an open repository for small molecules and their experimental biological activity. integrates provides search, retrieval, visualization, analysis, programmatic access tools in effort to maximize the utility of contributed information. There are many diverse chemical structures with similar efficacies against targets available that difficult interrelate using traditional 2-D similarity methods. A new layer called PubChem3D added assist this analysis.PubChem generates a 3-D...
Background: Fusion transcripts are formed by either fusion genes (DNA level) or trans-splicing events (RNA level). They have been recognized as a promising tool for diagnosing, subtyping and treating cancers. RNA-seq has become precise efficient standard genome-wide screening of such aberration events. Many transcript detection algorithms developed paired-end data but their performance not comprehensively evaluated to guide practitioners. In this paper, we 15 popular precision recall...
PubChem is a chemical information repository, consisting of three primary databases: Substance, Compound, and BioAssay. When individual data contributors submit substance descriptions to the unique structures are extracted stored into Compound through an automated process called structure standardization. The present study describes standardization approaches analyzes them for their success rates, reasons that cause be rejected, modifications applied during process. Furthermore, compared...
PubChem (http://pubchem.ncbi.nlm.nih.gov) is a public repository for information on chemical substances and their biological activities, developed maintained by the US National Institutes of Health (NIH). contains more than 180 million depositor-provided substance descriptions, 60 unique structures 225 bioactivity assay results, covering 9000 protein target sequences. As an resource biology research community, it routinely receives 1 requests per day from estimated users month. Programmatic...
The increased multi-omics information on carefully phenotyped patients in studies of complex diseases requires novel methods for data integration. Unlike continuous intensity measurements from most omics sets, phenome contain clinical variables that are binary, ordinal and categorical.In this paper we introduce an integrative phenotyping framework (iPF) disease subtype discovery. A feature topology plot was developed effective dimension reduction visualization data. approach is free model...
PubChem (https://pubchem.ncbi.nlm.nih.gov) is one of the largest open chemical information resources available. It currently receives millions unique users per month on average, serving as a key resource for many research fields such cheminformatics, biology, medicinal chemistry, and drug discovery. provides multiple programmatic access routes to its data services. One them PUG-REST, Representational State Transfer (REST)-like web service interface PubChem. On PUG-REST more than million...
PubChem (https://pubchem.ncbi.nlm.nih.gov) is a public chemical database that serves scientific communities as well the general public. This collects information from hundreds of data sources and organizes them into multiple collections, including Substance, Compound, BioAssay, Protein, Gene, Pathway, Patent. These collections are interlinked with each other, allowing users to discover related records in various (e.g., drugs targeting protein or genes modulated by chemical). can be searched...
PubChem (https://pubchem.ncbi.nlm.nih.gov) is a public chemical database at the U.S. National Institutes of Health. Visited by millions users every month, it plays role as key information resource for biomedical research communities. Data in from hundreds contributors and organized into multiple collections record type. Among these are Protein, Gene, Pathway, Taxonomy data collections. Records contain on chemicals related to given biological target (i.e., protein, gene, pathway, or taxon),...
PubChem is a free and publicly available resource containing substance descriptions their associated biological activity information. PubChem3D an extension to computationally-derived three-dimensional (3-D) structures of small molecules. All the tools services that are part rely upon quality 3-D conformer models. Construction models currently in involves clustering stage sample conformational space spanned by molecule. While this allows one downsize more manageable size, it may result loss...
PubChem is an open archive consisting of a set three primary public databases (BioAssay, Compound, and Substance). It contains information on broad range chemical entities, including small molecules, lipids, carbohydrates, (chemically modified) amino acid nucleic sequences (including siRNA miRNA). Currently (as Nov. 2015), more than 150 million depositor-provided substance descriptions, 60 unique structures, 225 biological activity test results provided from over 1 assay records. Many...