A5048286090- Health, Environment, Cognitive Aging
- Metabolomics and Mass Spectrometry Studies
- Advanced Chemical Sensor Technologies
- Nutritional Studies and Diet
- scientometrics and bibliometrics research
- Analytical Chemistry and Chromatography
- Pharmaceutical and Antibiotic Environmental Impacts
- Water Quality Monitoring and Analysis
- Effects and risks of endocrine disrupting chemicals
- Per- and polyfluoroalkyl substances research
- Air Quality and Health Impacts
- Research Data Management Practices
- Gut microbiota and health
- Mass Spectrometry Techniques and Applications
- Toxic Organic Pollutants Impact
University of Luxembourg
2021-2025
Finding relevant chemicals in the vast (known) chemical space is a major challenge for environmental and exposomics studies leveraging nontarget high resolution mass spectrometry (NT-HRMS) methods. Chemical databases now contain hundreds of millions chemicals, yet many are not relevant. This article details an extensive collaborative, open science effort to provide dynamic collection environmental, metabolomics, research, along with supporting information about their relevance assist...
ADVERTISEMENT RETURN TO ISSUEViewpointNEXTAvoiding the Next Silent Spring: Our Chemical Past, Present, and FutureHans Peter H. Arp*Hans ArpNorwegian Geotechnical Institute (NGI), P.O. Box 3930, Ullevål Stadion, 0806 Oslo, NorwayDepartment of Chemistry, Norwegian University Science Technology (NTNU), 7491 Trondheim, Norway*[email protected]More by Hans ArpView Biographyhttps://orcid.org/0000-0002-0747-8838, Dagny AurichDagny AurichLuxembourg Centre for Systems Biomedicine (LCSB), Luxembourg,...
Nontargeted screening (NTS) utilizing liquid chromatography electrospray ionization high-resolution mass spectrometry (LC/ESI/HRMS) is increasingly used to identify environmental contaminants. Major differences in the efficiency of compounds ESI/HRMS result widely varying responses and complicate quantitative analysis. Despite an increasing number methods for quantification without authentic standards NTS, approaches are evaluated on limited diverse data sets with chemical coverage collected...
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease, with an increasing incidence in recent years due to aging population. Genetic mutations alone only explain <10% of PD cases, while environmental factors, including small molecules, may play a significant role PD. In present work, 22 plasma (11 PD, 11 control) and 19 feces samples (10 9 were analyzed by non-target high-resolution mass spectrometry (NT-HRMS) coupled two liquid chromatography (LC) methods...
Abstract Awareness of the exposome and its influence on health has increased in last decade. As past exposures can cause changes human many years later, delving into is relevant for both diagnostic prevention purposes, but remains a challenging task. Lifestyle, diet, socioeconomic information should be well documented compatible with modern data science methods. While chemical analysis nowadays makes use high resolution mass spectrometry (HR-MS) highly sensitive comprehensive coverage...
The Luxembourg Time Machine (LuxTIME) is an interdisciplinary project that studies the historical exposome during industrialization of Minett region, located in south Luxembourg. Exposome research encompasses all external and internal non-genetic factors influencing health population, such as air pollution, green spaces, noise, work conditions, physical activity, diet. Due to wide scope project, study Belval involved collection quantitative qualitative data from National Archive Luxembourg,...
Understanding historical chemical usage is crucial for assessing current and past impacts on human health the environment informing future regulatory decisions. However, monitoring data often limited in scope number of chemicals, while suitable sample types are not always available remeasurement. Data-driven cheminformatics methods patent literature offer several opportunities to fill this gap. The stripes were developed as an interactive, open source tool visualising trends over time,...
Understanding historical chemical usage is crucial for assessing current and past impacts on human health the environment informing future regulatory decisions. However, monitoring data are often limited in scope number of chemicals, while suitable sample types not always available remeasurement. Data-driven cheminformatics methods patent literature offer several opportunities to fill this gap. The
Abstract Background Non-target screening of surface water samples collected over an extended period can reveal interesting temporal patterns in exposome-related pollutants. Additionally, geographical data on pollution sources close to the sampling sites, chemical classification and consideration flow paths provide valuable information origins potential threat tentatively identified compounds. In this study, 271 from 20 sites across Luxembourg were analysed using high-resolution mass...
Finding relevant chemicals in the vast (known) chemical space is a major challenge for environmental and exposomics studies leveraging non-target high resolution mass spectrometry (NT-HRMS) methods. Chemical databases now contain hundreds of millions chemicals, yet many are not relevant. This article details an extensive collaborative, open science effort to provide dynamic collection environmental, metabolomics research, along with supporting information about their relevance assist...
Abstract Background Non-target screening of surface water samples collected over an extended period can reveal interesting temporal patterns in exposome-related pollutants. Additionally, geographical data on pollution sources close to the sampling sites, chemical classification and consideration flow paths provide valuable information origins potential threat tentatively identified compounds. In this study, 271 from 20 sites across Luxembourg were analysed using high resolution mass...
Abstract The exposome complements information captured in the genome by covering all external influences and internal (biological) responses of a human being from conception onwards. Such paradigm goes beyond single scientific discipline instead requires truly interdisciplinary approach. concept “historical exposomics” could help bridge gap between “nature” “nurture” using both natural social archives to capture influence humans on earth (the Anthropocene) an manner. LuxTIME project served...