A5057941837- Pharmaceutical and Antibiotic Environmental Impacts
- Toxic Organic Pollutants Impact
- Mass Spectrometry Techniques and Applications
- Effects and risks of endocrine disrupting chemicals
- Forensic and Genetic Research
- Isotope Analysis in Ecology
- Environmental Toxicology and Ecotoxicology
- Analytical chemistry methods development
- Per- and polyfluoroalkyl substances research
- Pharmacological Effects and Assays
- Analytical Chemistry and Chromatography
- Growth Hormone and Insulin-like Growth Factors
- Metabolomics and Mass Spectrometry Studies
- Scientific Computing and Data Management
- Muscle metabolism and nutrition
- Data Quality and Management
- Pain Management and Opioid Use
- Pharmaceutical Practices and Patient Outcomes
- Antibiotic Use and Resistance
- Research Data Management Practices
- SARS-CoV-2 detection and testing
- Water Treatment and Disinfection
- Chemistry and Chemical Engineering
- Cardiac, Anesthesia and Surgical Outcomes
- Hormonal and reproductive studies
Environmental Institute
2021-2024
Masaryk University
2022-2024
King's College London
2021
Abstract Background The NORMAN Association ( https://www.norman-network.com/ ) initiated the Suspect List Exchange (NORMAN-SLE; https://www.norman-network.com/nds/SLE/ in 2015, following collaborative trial on non-target screening of environmental water samples by mass spectrometry. Since then, this exchange information chemicals that are expected to occur environment, along with accompanying expert knowledge and references, has become a valuable base for “suspect screening” lists....
Abstract Background Prioritisation of chemical pollutants is a major challenge for environmental managers and decision-makers alike, which essential to help focus the limited resources available monitoring mitigation actions on most relevant chemicals. This study extends original NORMAN prioritisation scheme beyond target chemicals, presenting integration semi-quantitative data from retrospective suspect screening expansion existing exposure risk indicators. The utilises retrieved...
Nontargeted screening (NTS) utilizing liquid chromatography electrospray ionization high-resolution mass spectrometry (LC/ESI/HRMS) is increasingly used to identify environmental contaminants. Major differences in the efficiency of compounds ESI/HRMS result widely varying responses and complicate quantitative analysis. Despite an increasing number methods for quantification without authentic standards NTS, approaches are evaluated on limited diverse data sets with chemical coverage collected...
The occurrence of antibiotics in the environment could result development antibiotic-resistant bacteria, which a public health crisis. 676 and main transformation products (TPs) was investigated 48 wastewater treatment plants (WWTPs) from 11 countries (Germany, Romania, Serbia, Croatia, Slovenia, Hungary, Slovakia, Czechia, Austria, Cyprus, Greece) by target suspect screening. Target screening involved investigation with reference standards (40 antibiotics). Suspect covered retrieved NORMAN...
Wastewater treatment plants (WWTPs) represent an important input of contaminants in the environment. Therefore, it is critical to continuously monitor performance WWTPs take appropriate action and avoid influx In this study, a battery seven vitro bioassays covering selected spectrum toxicity effects proposed for quality control wastewater effluents. The address mixture toxicity, which combined adverse effect multiple can act as early warning system. was applied samples from 11 representative...
Abstract The administration of growth hormone releasing (GHRH) and its synthetic analogs is prohibited by the World Anti‐Doping Agency (WADA). Although there evidence their use, based on admissions intelligence, they do not appear to have been found in anti‐doping samples WADA accredited laboratories. This might be due small concentration urine limited knowledge about metabolism, especially for unapproved analogs. study investigates vitro metabolism detection four larger GHRH (sermorelin,...
Abstract Background: The NORMAN Association (https://www.norman-network.com/) initiated the Suspect List Exchange (NORMAN-SLE; https://www.norman-network.com/nds/SLE/) in 2015, following collaborative trial on non-target screening of environmental water samples by mass spectrometry. Since then, this exchange information chemicals that are expected to occur environment, along with accompanying expert knowledge and references, has become a valuable base for “suspect screening” lists....
Abstract Environmental studies which aim to assess the ecological impact of chemical and other types pollution should employ a complex weight-of-evidence approach with multiple lines evidence (LoEs). This study focused on in situ genotoxicological methods such as comet micronucleus assays randomly amplified polymorphic DNA analysis one LoEs (LoE3) fish species Alburnus alburnus (bleak) bioindicator. The was carried out within Joint Danube Survey 4 (JDS4) at nine sites River Basin Republic...
<title>Abstract</title> <italic><bold>Background</bold></italic>: Prioritisation of chemical pollutants is a major challenge for environmental managers and decision-makers alike, which essential to help focus the limited resources available monitoring mitigation actions on most relevant chemicals. This study extends original NORMAN prioritisation scheme beyond target chemicals, presenting integration semi-quantitative data from retrospective suspect screening expansion existing exposure risk...
Per- and polyfluoroalkyl substances (PFAS) are under regulatory scrutiny since they persistent, bioaccumulative, toxic. The occurrence of 4,777 PFAS was investigated in the Danube River Basin (DRB; 11 countries) using target suspect screening. Target screening involved investigation with 56 commercially available reference standards. Suspect covered retrieved from NORMAN Substance Database, including all individual lists submitted to List Exchange Database. Mass spectrometry fragmentation...