A5003117330- Metabolomics and Mass Spectrometry Studies
- Health, Environment, Cognitive Aging
- Phytochemicals and Antioxidant Activities
- Mass Spectrometry Techniques and Applications
- Tea Polyphenols and Effects
- Nutrition, Genetics, and Disease
- Nutritional Studies and Diet
- Gut microbiota and health
- Phytoestrogen effects and research
- Forensic and Genetic Research
- Isotope Analysis in Ecology
- Computational Drug Discovery Methods
- Fermentation and Sensory Analysis
- Diet and metabolism studies
- Biomedical Text Mining and Ontologies
- Analytical chemistry methods development
- Pharmacological Effects and Assays
- Analytical Chemistry and Chromatography
- Ginseng Biological Effects and Applications
- Pharmaceutical and Antibiotic Environmental Impacts
- Consumer Attitudes and Food Labeling
- Insect and Pesticide Research
- Food Quality and Safety Studies
- Antioxidant Activity and Oxidative Stress
- Pharmacogenetics and Drug Metabolism
Centre International de Recherche sur le Cancer
2013-2023
University of Copenhagen
2015
National Institute for Nanotechnology
2009-2013
University of Alberta
2009-2012
Clermont Université
2010
Unité de Nutrition Humaine
2010
Centre de Recherche en Nutrition Humaine d'Auvergne
2010
Institut National de la Recherche Agronomique
2010
The Human Metabolome Database or HMDB (www.hmdb.ca) is a web-enabled metabolomic database containing comprehensive information about human metabolites along with their biological roles, physiological concentrations, disease associations, chemical reactions, metabolic pathways, and reference spectra. First described in 2007, the now considered standard resource for studies. Over past decade has continued to grow evolve response emerging needs metabolomics researchers continuing changes web...
The Human Metabolome Database (HMDB) (www.hmdb.ca) is a resource dedicated to providing scientists with the most current and comprehensive coverage of human metabolome. Since its first release in 2007, HMDB has been used facilitate research for nearly 1000 published studies metabolomics, clinical biochemistry systems biology. recent (version 3.0) significantly expanded enhanced over 2009 2.0). In particular, number annotated metabolite entries grown from 6500 more than 40 000 (a 600%...
DrugBank (http://www.drugbank.ca) is a comprehensive online database containing extensive biochemical and pharmacological information about drugs, their mechanisms targets. Since it was first described in 2006, has rapidly evolved, both response to user requests changing trends drug research development. Previous versions of have been widely used facilitate silico target discovery. The latest update, 4.0, further expanded contain data on metabolism, absorption, distribution, excretion...
DrugBank ( http://www.drugbank.ca ) is a richly annotated database of drug and target information. It contains extensive data on the nomenclature, ontology, chemistry, structure, function, action, pharmacology, pharmacokinetics, metabolism pharmaceutical properties both small molecule large (biotech) drugs. also comprehensive information diseases, proteins, genes organisms which these drugs act. First released in 2006, has become widely used by pharmacists, medicinal chemists, researchers,...
A number of databases on the plant metabolome describe chemistry and biosynthesis chemicals. However, no such database is specifically focused foods more precisely polyphenols, one major classes phytochemicals. As antoxidants, polyphenols influence human health may play a role in prevention chronic diseases as cardiovascular diseases, some cancers or type 2 diabetes. To determine polyphenol intake populations study their association with health, it essential to have detailed information...
Polyphenols are a major class of bioactive phytochemicals whose consumption may play role in the prevention number chronic diseases such as cardiovascular diseases, type II diabetes and cancers. Phenol-Explorer, launched 2009, is only freely available web-based database on content polyphenols food their vivo metabolism pharmacokinetics. Here we report third release (Phenol-Explorer 3.0), which adds data effects processing polyphenol contents foods. Data >100 foods, covering 161 or groups...
Considerable information on polyphenol content in foods is scattered up to 1000 peer-reviewed publications and therefore not easily exploited. Over 60000 food composition data have been collected from this literature stored the new Phenol-Explorer database (www.phenol-explorer.eu). Thirty-seven thousand were selected after evaluation aggregated separately according 5 categories of analytical methods generate mean values for 502 compounds (glycosides, esters, or aglycones) 452 foods. These...
Abstract Background The NORMAN Association ( https://www.norman-network.com/ ) initiated the Suspect List Exchange (NORMAN-SLE; https://www.norman-network.com/nds/SLE/ in 2015, following collaborative trial on non-target screening of environmental water samples by mass spectrometry. Since then, this exchange information chemicals that are expected to occur environment, along with accompanying expert knowledge and references, has become a valuable base for “suspect screening” lists....
The Yeast Metabolome Database (YMDB, http://www.ymdb.ca) is a richly annotated 'metabolomic' database containing detailed information about the metabolome of Saccharomyces cerevisiae. Modeled closely after Human Database, YMDB contains >2000 metabolites with links to 995 different genes/proteins, including enzymes and transporters. in has been gathered from hundreds books, journal articles electronic databases. In addition its comprehensive literature-derived data, also an extensive...
Phenol-Explorer, launched in 2009, is the only comprehensive web-based database on content foods of polyphenols, a major class food bioactives that receive considerable attention due to their role prevention diseases. Polyphenols are rarely absorbed and excreted ingested forms, but extensively metabolized body, until now, no has allowed recall identities concentrations polyphenol metabolites biofluids after consumption polyphenol-rich sources. Knowledge these essential planning experiments...
In an effort to capture meaningful biological, chemical and mechanistic information about clinically relevant, commonly encountered or important toxins, we have developed the Toxin Toxin-Target Database (T3DB). The T3DB is a unique bioinformatics resource that compiles comprehensive common ubiquitous toxins their toxin-targets into single electronic repository. database currently contains over 2900 small molecule peptide 1300 more than 33 000 toxin-target associations. Each record (ToxCard)...
Exposome-Explorer (http://exposome-explorer.iarc.fr) is the first database dedicated to biomarkers of exposure environmental risk factors. It contains detailed information on nature biomarkers, their concentrations in various human biospecimens, study population where measured and analytical techniques used for measurement. also correlations with external measurements data biological reproducibility over time. The was manually collected from peer-reviewed publications organized make it...
Scope The Phenol‐Explorer web database ( http://www.phenol‐explorer.eu ) was recently updated with new data on polyphenol retention due to food processing. Here, we analyze these investigate the effect of different variables content and make recommendations aimed at refining estimation intake in epidemiological studies. Methods results Data effects processing upon 161 polyphenols compiled for were analyzed structure, food, process loss. These expressed as factors (RFs), fold changes Domestic...
Metabolites produced by the gut microbiota play an important role in cross-talk with human host. Many microbial metabolites are biologically active and can pass barrier make it into systemic circulation, where they form exposome, i.e. totality of body fluids or tissues A major difficulty faced when studying exposome its health diseases is to differentiate solely partially derived from metabolism those host coming diet. Our objective was collect data scientific literature build a database on...
Scope The Phenol‐Explorer web database details 383 polyphenol metabolites identified in human and animal biofluids from 221 publications. Here, we exploit these data to characterize visualize the metabolome, set of all derived phenolic food components. Methods results Qualitative quantitative on as described 424 intervention studies were systematically analyzed. Of metabolites, 301 without prior enzymatic hydrolysis biofluids, included glucuronide sulfate esters, glycosides, aglycones, O...
Exposome-Explorer (http://exposome-explorer.iarc.fr) is a database of dietary and pollutant biomarkers measured in population studies. In its first release, contained comprehensive information on 692 pollution exposures extracted from the analysis 480 peer-reviewed publications. Today, has been further expanded contains total 908 biomarkers. Two additional types have collected. First, 185 candidate having 403 associations with food intake (as by metabolomic studies) identified added. Second,...
Abstract Background: The NORMAN Association (https://www.norman-network.com/) initiated the Suspect List Exchange (NORMAN-SLE; https://www.norman-network.com/nds/SLE/) in 2015, following collaborative trial on non-target screening of environmental water samples by mass spectrometry. Since then, this exchange information chemicals that are expected to occur environment, along with accompanying expert knowledge and references, has become a valuable base for “suspect screening” lists....
Introduction: The identification and selection of the most relevant exposure biomarkers for epidemiological studies is complex many parameters must be taken into consideration. We present here Exposome-Explorer, a new database web application specifically designed collection, organization retrieval information on to dietary environmental risk factors measured in or biomonitoring studies. Methods: Highly detailed pollution exposures population was systematically collected from peer-reviewed...
Objective: In 2016, the International Agency for Research on Cancer, part of World Health Organization, released Exposome-Explorer, first database dedicated to biomarkers exposure environmental risk factors diseases. The contents resulted from a manual literature search that yielded over 8,500 citations, but only small fraction these publications were used in final database. Manually curating is time-consuming and requires domain expertise gather relevant data scattered throughout millions...
Abstract In 2016, the International Agency for Research on Cancer, part of World Health Organization, released Exposome-Explorer, first database dedicated to biomarkers exposure environmental risk factors diseases. The contents resulted from a manual literature search that yielded over 8500 citations, but only small fraction these publications were used in final database. Manually curating is time-consuming and requires domain expertise gather relevant data scattered throughout millions...