A5019514495- Metabolomics and Mass Spectrometry Studies
- Advanced Chemical Sensor Technologies
- Fermentation and Sensory Analysis
- Toxic Organic Pollutants Impact
- Adipose Tissue and Metabolism
- Analytical Chemistry and Chromatography
- Horticultural and Viticultural Research
- Diet and metabolism studies
- Gut microbiota and health
- Nutrition, Genetics, and Disease
- Phytochemistry and Biological Activities
- Nutritional Studies and Diet
- Effects and risks of endocrine disrupting chemicals
- Health, Environment, Cognitive Aging
- Muscle metabolism and nutrition
- Phytochemicals and Antioxidant Activities
- Pesticide Residue Analysis and Safety
- Computational Drug Discovery Methods
- Drug Transport and Resistance Mechanisms
- Plant biochemistry and biosynthesis
- Natural product bioactivities and synthesis
- Hormonal and reproductive studies
- Traditional Chinese Medicine Analysis
- Fungal Biology and Applications
- Spectroscopy and Chemometric Analyses
Universidad de Granada
2023-2024
Oniris
2019-2022
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2022
Laboratoire D'étude des Résidus et Contaminants Dans les Aliments
2019-2022
University of Parma
2022
Fondazione Edmund Mach
2015-2020
University of Trento
2015
We analyzed via untargeted UHPLC-ESI-Q-TOF-MS the metabolome of berry tissues (skin, pulp, seeds) some American Vitis species (Vitis cinerea, californica, arizonica), together with four interspecific hybrids, and seven vinifera cultivars, aiming to find differences in metabolomes sp. versus vinifera. Apart from known differences, that is, more complex content anthocyanins stilbenoids grapes, we observed higher procyanidin accumulation (tens hundreds times) skin seeds comparison berries,...
For decades, (poly)phenols have been linked to cardiometabolic health, but population heterogeneity limits their apparent efficacy and the development of tailored, practical protocols in dietary interventions. This is likely determined by existence different metabotypes, sub-populations individuals metabolizing some classes differently. The gut microbiota plays a major role this process. impact microbiota-related phenolic metabotypes on health becoming evident, although picture still...
Hydrophilic Interaction Liquid Chromatography (HILIC) chromatography is widely applied in metabolomics as a complementary strategy to reverse phase chromatography. Nevertheless, it still faces several issues terms of peak shape and compounds ionization, limiting the automatic de-convolution data semi-quantification performed through dedicated software. A way improve chromatographic ionization performance HILIC method modify electrostatic interactions analytes with both mobile stationary...
Abstract Growth hormone (GH), an endogenous peptide regulating anabolism and lipolysis in humans, is known to be abused by athletes improve their performance. Despite the development of two distinct screening methods, few positive cases have been reported antidoping authorities, probably due quick turnover GH masking effects age, ethnicity, sex. Apart from growth regulation, affect several metabolic pathways humans including ketosis, amino‐acid uptake, protein breakdown. It reasonable...
Polychlorinated biphenyls (PCBs) are a class of contaminants great concern, linked to the development many chronic diseases. Adverse effects PCBs have been documented in humans after accidental and massive exposure. However, little is known about effect exposure low-dose PCB mixtures, studies regarding scattered lifetime exposures non-dioxin-like (NDL)-PCBs especially missing. In this work, serum samples from pigs chronically exposed through their diet during 22 days Aroclor 1260 (i.e....
Growth Hormone (GH) under its human recombinant homologue (rhGH), may be abused by athletes to take advantage of well-known anabolic and lipolytic properties; hence it is prohibited in sports the World Anti-Doping Agency. Due rapid turnover rhGH, anti-doping screening tests have turned monitor two endocrine biomarkers (IGF-I P-III-NP), but unfortunately, they show population-wise variability, limiting identification rate rhGH users. Previous studies evidenced numerous effects GH on...
Cationic, anionic, zwitterionic and, partially polar metabolites are very important constituents of blood serum. Several these underpin the core metabolism cells (e.g., Krebs cycle, urea proteins synthesis, etc.), while others might be considered ancillary but still to grasp status any organism through serum analysis. Due its wide chemical diversity, modern metabolomics analysis is struggling provide a complete and comprehensive picture metabolome, due limitations each specific analytical...
Compound identification is the main hurdle in LC-HRMS-based metabolomics, given high number of 'unknown' metabolites. In recent years, numerous silico fragmentation simulators have been developed to simplify and improve mass spectral interpretation compound annotation. Nevertheless, expert spectrometry users chemists are still needed select correct entry from candidates proposed by automatic tools, especially plant kingdom due huge structural diversity natural compounds occurring plants....
Abstract Phyto-thermotherapy is a treatment consisting in immersing oneself baths of self-heating alpine grass, to benefit the heat and rich aromatic components released by process. The aim this study was characterize bacterial fungal diversity three phyto-thermal (PTB) performed different months, compare data with profile volatile organic compounds (VOCs) All collected showed that PTBs were structured two stages: first days characterised an exponential rise temperature, fast development,...
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Evidence shows that bioactive (poly)phenols are pivotal in the prevention of chronic diseases, particular cardiometabolic health. However, inter-individual variability existing their bioavailability and physiological response can impact true efficacy. Individuals showing similar metabolic profiles for specific be clustered into phenolic metabotypes, while comprehensive derived from main dietary could referred to as "aggregate metabotypes". The aim study is identify aggregate metabotypes...