A5058621397- Metabolomics and Mass Spectrometry Studies
- Per- and polyfluoroalkyl substances research
- Mass Spectrometry Techniques and Applications
- Toxic Organic Pollutants Impact
- Analytical Chemistry and Chromatography
- Isotope Analysis in Ecology
- Chemical Safety and Risk Management
- Effects and risks of endocrine disrupting chemicals
- Radiation Detection and Scintillator Technologies
- Inhalation and Respiratory Drug Delivery
- Advanced Chemical Sensor Technologies
- Atmospheric chemistry and aerosols
- Pesticide Residue Analysis and Safety
- AI in cancer detection
- Pharmaceutical and Antibiotic Environmental Impacts
- Adsorption, diffusion, and thermodynamic properties of materials
- Hydrological Forecasting Using AI
- Forensic Toxicology and Drug Analysis
- Air Quality and Health Impacts
- Analytical chemistry methods development
- Water Quality and Pollution Assessment
- Alcohol Consumption and Health Effects
- Forensic and Genetic Research
- Air Quality Monitoring and Forecasting
- Anomaly Detection Techniques and Applications
The University of Queensland
2020-2024
Landeswasserversorgung (Germany)
2020
University of Cologne
2018
Abstract Increasing production and use of chemicals awareness their impact on ecosystems humans has led to large interest for broadening the knowledge chemical status environment human health by suspect non-target screening (NTS). To facilitate effective implementation NTS in scientific, commercial governmental laboratories, as well acceptance managers, regulators risk assessors, more harmonisation is required. address this, NORMAN Association members involved activities have prepared this...
The application of non-target analysis (NTA), a comprehensive approach to characterize unknown chemicals, including chemicals emerging concern has seen steady increase recently. Given the relative novelty this type analysis, robust quality assurance and control (QA/QC) measures are imperative ensure consistency results obtained using different workflows. Due fundamental differences established targeted workflows, new or expanded approaches necessary; for example minimize risk losing...
While several sources of per- and polyfluoroalkyl substances (PFAS) are known, their use in consumer household products is far less explored. The aim this study was to provide comprehensive bottom-up analysis the types concentrations PFAS reported literature over past decade. A total 52 studies revealed 107 belonging 15 different categories 1040 products. highest number tested were from USA (n=389) followed by Czech Republic (n=111). Mean firefighting products, textile finishing agents...
Monitoring contamination from per- and polyfluoroalkyl substances (PFASs) in water systems impacted by aqueous film-forming foams (AFFFs) typically addresses a few known PFAS groups. Given the diversity of PFASs present AFFFs, current analytical approaches do not comprehensively address range these systems. A suspect-screening nontarget analysis (NTA) approach was developed applied to identify novel groundwater samples contaminated historic AFFF use. total 88 were identified both passive...
Nontargeted screening (NTS) utilizing liquid chromatography electrospray ionization high-resolution mass spectrometry (LC/ESI/HRMS) is increasingly used to identify environmental contaminants. Major differences in the efficiency of compounds ESI/HRMS result widely varying responses and complicate quantitative analysis. Despite an increasing number methods for quantification without authentic standards NTS, approaches are evaluated on limited diverse data sets with chemical coverage collected...
Abstract Non-target analysis (NTA) employing high-resolution mass spectrometry is a commonly applied approach for the detection of novel chemicals emerging concern in complex environmental samples. NTA typically results large and information-rich datasets that require computer aided (ideally automated) strategies their processing interpretation. Such do however raise challenge reproducibility between within different workflows. An effective strategy to mitigate such problems implementation...
As Europe's second longest river, the Danube is an important water source for drinking and irrigation many countries, before discharging into Black Sea in East. Per- poly-fluoroalkyl substances (PFAS) have been observed over last two decades concentrations exceeding European Union's guidelines total sum of 20 select PFAS 0.1 μg L
The use of peak-picking algorithms is an essential step in all nontarget analysis (NTA) workflows. However, algorithm choice may influence reliability and reproducibility results. Using a real-world data set, the aim this study was to investigate how different NTA results when exploring temporal and/or spatial trends. For this, drinking water catchment monitoring data, using passive samplers collected twice per year across Southeast Queensland, Australia (n = 18 sites) between 2014 2019,...
Analyte transformation post-sample collection can introduce uncertainty and reduce the reproducibility reliability of results during non-targeted analysis (NTA) environmental samples. Understanding type degree information lost is critical for accurate interpretation experimental results. Changes in NTA feature profile a sample were assessed over immediate-to-short term (i.e., first 24 subsequent 120 h) to determine how much or changed. A wastewater was analyzed within 90 min using liquid...
Non-target analysis (NTA) using high-resolution mass spectrometry is becoming a useful approach to screen for suspect and unknown chemicals. For comprehensive analyses, data-independent acquisition (DIA), like Sequential Windowed Acquisition of all THeoretical Mass Spectra (SWATH-MS) on Sciex instruments, necessary, usually followed by library matching feature annotation. The choice parameters, such as window number size, may influence the comprehensiveness features detected. goal this study...