A5043950989- Pharmaceutical and Antibiotic Environmental Impacts
- Analytical chemistry methods development
- Analytical Chemistry and Chromatography
- Aquaculture disease management and microbiota
- Aquaculture Nutrition and Growth
- Microplastics and Plastic Pollution
- Metabolomics and Mass Spectrometry Studies
- Advanced Chemical Sensor Technologies
- Insect and Pesticide Research
- Water Treatment and Disinfection
- Animal Behavior and Welfare Studies
- Environmental Toxicology and Ecotoxicology
- Amphibian and Reptile Biology
- Effects and risks of endocrine disrupting chemicals
- Pesticide Residue Analysis and Safety
- Toxic Organic Pollutants Impact
- Neuroendocrine regulation and behavior
- Insect Utilization and Effects
- Environmental Chemistry and Analysis
- Chemistry and Chemical Engineering
- Recycling and Waste Management Techniques
- Pharmacological Effects and Assays
- Cardiovascular Conditions and Treatments
- Mass Spectrometry Techniques and Applications
- Membrane Separation Technologies
University of Copenhagen
2021-2025
University of Tübingen
2018-2021
Aarhus University
2020
DVGW - Technologiezentrum Wasser
2017
Reusable plastic sports bottles are used extensively worldwide, and little is known about the migration of chemicals from into drinking water. In this study, we investigated chemical water stored for 24 h in new bottles, washed dishwasher. Non-target screening (NTS) by liquid-chromatography – high-resolution mass spectrometry (LC-HRMS) was performed to identify these compounds. We detected > 3500 dishwasher related compounds, with 430 showing even after subsequent flushing bottles. addition,...
This study explores the correlation of contaminants emerging concern (CECs) in wastewater effluents using liquid chromatography (LC), supercritical fluid (SFC), and comprehensive two-dimensional gas (GC × GC) with derivatization, all coupled to high-resolution mass spectrometry (HRMS). Over 300 compounds, including frequently overlooked highly polar nonpharmaceutical CECs, were identified. Monitoring programs mainly focus on reducing variability assessing pollution treatment plant (WWTP)...
Standard monitoring programs give limited insight into groundwater status, especially transformation products (TPs) formed by natural processes or advanced oxidation (AOP), are normally underrepresented. In this study, using suspect and non-target screening, we performed a comprehensive analysis of before after AOP UV/H2O2 consecutively installed biological activated carbon filters (BAC). By up to 413 compounds were detected in the groundwater, with an average 70% removal AOP. However,...
Nontargeted screening (NTS) utilizing liquid chromatography electrospray ionization high-resolution mass spectrometry (LC/ESI/HRMS) is increasingly used to identify environmental contaminants. Major differences in the efficiency of compounds ESI/HRMS result widely varying responses and complicate quantitative analysis. Despite an increasing number methods for quantification without authentic standards NTS, approaches are evaluated on limited diverse data sets with chemical coverage collected...
Fluoxetine has been recognized as one of the most toxic pharmaceuticals in aquatic environment. Since there is growing evidence that potential fluoxetine surface waters markedly influenced by its own metabolism species, this study investigated biotransformation zebrafish embryo - an model organism intermediate complexity. Zebrafish embryos were exposed to 0.1, 1.0, 10, 50, and 5000 μg/L from 48 120 h post-fertilization (hpf), accumulation metabolites was analyzed over time. Additionally,...
Matrix effects are well-known challenges for accurate and comparable measurements with liquid chromatography (LC) electrospray ionization mass spectrometry (ESI–MS). This study describes a three-step method to evaluate compensate matrix in enriched wastewater extracts using LC ESI-high-resolution MS (HRMS). As first step, the "dilute shoot" approach was used determine optimal relative enrichment factor (REF) direct comparison between influent (REF 10) effluent 50) extracts. However, rapid...
In this study, micropollutants in wastewater effluents were prioritized by monitoring the composition of influent and effluent liquid chromatography - high-resolution mass spectrometry (LCHRMS) non-target screening (NTS) analysis. The study shows how important data pre-processing filtering raw is to produce reliable NTS for comparison compounds between many samples (37 samples) analyzed at different times. Triplicate injections critical reducing number false-positive detections. Intensity...
Polyethylene (PE) pipes are often the material of choice for water supply systems, thanks to their favorable properties, such as high strength-density ratio and corrosion resistance. However, previous studies have shown that organic compounds can migrate from PE water. This study aimed identify potential migrating high-density (HDPE) used distribute drinking in Denmark, based on laboratory experiments sampling distribution system using a two-tiered design. In first tier, migration volatile...
Quantitative nontarget analysis (qNTA) for liquid chromatography coupled to high-resolution mass spectrometry enables a more comprehensive assessment of environmental samples. Previous studies have shown that correlations between compound's ionization efficiency and range molecular descriptors can predict the concentration within factor 5. In this study, qNTA approach was further improved by considering all adducts instead only protonated ion. The model based on quantitative...
Abstract Liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) is commonly used for identification of compounds in complex samples due the high chromatographic and spectral resolution provided. In subsequent data processing workflows, it imperative preserve this fully exploit data. “Region interest” (ROI) algorithms were introduced as a better alternative equidistant binning compressing HRMS because they resolution. paper, we present new ROI algorithm that improves on...
Due to the rising number of type 2 diabetes patients, antidiabetic drug, metformin is currently among those pharmaceuticals with highest consumption rates worldwide. Via sewage-treatment plants, enters surface waters where it frequently detected in low concentrations (µg/L). Since possible adverse effects this substance aquatic organisms have been insufficiently explored date, aim study was investigate impact on health and development brown trout (Salmo trutta f. fario) its microbiome. Brown...
A QuEChERS based method with dispersive solid-phase extraction (d-SPE) clean-up followed by LC-MS-MS analysis was developed for simultaneous determination of seventeen multiclass antibiotics in sewage sludge and applied to samples from Nigeria.
The present study investigates the transformation of antidepressant fluoxetine (FLX) by photo- and biodegradation shows similarities differences in products (TPs). TPs were identified using LC-high-resolution mass spectrometry with positive negative electrospray ionization. In a sunlight simulator, photodegradation was carried out ultrapure water (pH 6, 8, 10) surface 8) to effect direct indirect photolysis, respectively. well-known metabolite norfluoxetine (NFLX) proved be minor TP...
Whether microplastics themselves or their interactions with chemicals influence the health and development of aquatic organisms has become a matter scientific discussion. In environments, several groups are abundant in parallel to microplastics. The tricyclic antidepressant amitriptyline is frequently prescribed, residues it regularly found surface waters. present study, irregularly shaped polystyrene (<50 µm), amitriptyline, mixture on early life-stages brown trout were investigated....
Background Over the last two decades, there has been a constant increase in prescription rates of antidepressants. In parallel, neuroactive pharmaceuticals are making their way into aquatic environments at increasing concentrations. Among antidepressants detected environment citalopram, selective serotonin reuptake inhibitor, is one most commonly found. Given citalopram specifically designed to alter mood and behaviour humans, growing concern it can adversely affect on non-target wildlife...
Broad screening approaches for monitoring wastewater are normally based on reversed-phase liquid chromatography (LC) coupled to high-resolution mass spectrometry (HRMS). This method is not sufficient the very polar micropollutants, neglected in past due a lack of suitable analytical methods. In this study, we used supercritical fluid (SFC) detect and yet-undetected micropollutants effluents. We tentatively identified 85 compounds, whereas 18 have only rarely been detected 11 previously...
This study aimed to investigate the spatial distribution of micropollutants in wastewater related catchment area, and their environmental risks fate. About 24-h flow proportional effluent (n = 26) samples were collected from eight WWTPs across Denmark. From five these corresponding influent 20) collected. Samples enriched by multi-layer solid phase analysed liquid chromatography-high-resolution mass spectrometry comprehensive two-dimensional gas chromatography with high-resolution detection....
Pharmaceuticals can enter surface waters via sewage treatment plants. In the environment, substances and their transformation products, formed by degradation of parent compounds, may affect aquatic wildlife including freshwater invertebrates. However, research on pharmaceutical-induced effects in feral organisms other than fish is still scarce to date. our study, we therefore investigated impact highly consumed antidiabetic drug metformin its main product guanylurea health a gastropod – big...