A5066207122- Pharmaceutical and Antibiotic Environmental Impacts
- SARS-CoV-2 detection and testing
- Antibiotic Use and Resistance
- Healthcare and Environmental Waste Management
- COVID-19 Clinical Research Studies
- COVID-19 and Mental Health
- COVID-19 impact on air quality
- Public Health Policies and Education
- Pharmaceutical Practices and Patient Outcomes
- Water Quality Monitoring and Analysis
- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Animal Disease Management and Epidemiology
- Zoonotic diseases and public health
- Analytical chemistry methods development
- Toxic Organic Pollutants Impact
- Metabolomics and Mass Spectrometry Studies
University of Bath
2022-2024
Institute for Sustainability
2023-2024
Ca' Foscari University of Venice
2022
Higher usage of antimicrobial agents in both healthcare facilities and the communities has resulted an increased spread resistant bacteria. However, improved infection prevention control practices may also contribute to decreasing resistance (AMR). In present study, wastewater-based epidemiology (WBE) approach was applied explore link between COVID-19 community antimicrobials, as well prevalence genes. Longitudinal study been conducted monitor levels 50 (AAs), 24 metabolites, 5 antibiotic...
Nontargeted screening (NTS) utilizing liquid chromatography electrospray ionization high-resolution mass spectrometry (LC/ESI/HRMS) is increasingly used to identify environmental contaminants. Major differences in the efficiency of compounds ESI/HRMS result widely varying responses and complicate quantitative analysis. Despite an increasing number methods for quantification without authentic standards NTS, approaches are evaluated on limited diverse data sets with chemical coverage collected...
This manuscript introduces a new wastewater-based epidemiology workflow for estimation of non-communicable diseases (NCDs) prevalence by using (WBE) and pharmaceuticals/their metabolites as proxies NCDs prevalence. 83 targets were selected (54 parent pharmaceuticals 29 metabolites). Three critical aspects tested: (i) Solid-Phase Extraction - Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry (SPE-UHPLC-MS/MS) method performance, (ii) biomarker stability under variable storage...
SARS-CoV-2 pandemic affected lifestyle habits, and the mental health wellbeing of people around world. In this manuscript, two towns (Paulton Radstock) cities (Bath Bristol) in Southwest England (> 1 million people) were monitored for years using Wastewater-Based Epidemiology to assess impacts COVID (including management measures such as lockdowns movement restrictions) on community choices: illicit drugs, legal stimulants, abused pharmaceuticals pain pharma usage. Results triangulated with...
SARS-CoV-2 pandemic had a significant impact on the society, economy, and health of people around world with consequences that need to be better understood for future preparedness. This manuscript provides insights into usage pharmaceuticals pain treatment management throughout pandemic. Four towns cities total population >1 million covering an area 2000 km2 in South West England were monitored twenty-four months. Results showed different patterns pharma usage, small having higher normalised...
<title>Abstract</title> The COVID-19 pandemic impacted antimicrobial resistance (AMR) in clinical settings, but evidence is lacking. Considering this, we evaluated community-wide AMR the shadow of COVID-19, using wastewater-based epidemiology (WBE). 590 wastewater samples were collected from four contrasting communities England between April 2020 and March 2022 to test for antibiotics used, their metabolites persistent antibiotic genes (ARGs). Catchment wide cases prescription data...