A5014708339- Pesticide Exposure and Toxicity
- Pesticide Residue Analysis and Safety
- Metabolomics and Mass Spectrometry Studies
- Insect and Pesticide Research
- Urban Green Space and Health
- Indoor Air Quality and Microbial Exposure
- Insect Utilization and Effects
- Effects and risks of endocrine disrupting chemicals
- Advanced Chemical Sensor Technologies
- Powder Metallurgy Techniques and Materials
- Cancer Cells and Metastasis
- Granular flow and fluidized beds
- Forensic Toxicology and Drug Analysis
- Isotope Analysis in Ecology
- Liver physiology and pathology
- Insect Pest Control Strategies
- Spectroscopy and Chemometric Analyses
- Healthcare and Environmental Waste Management
- Pharmaceutical and Antibiotic Environmental Impacts
- Carcinogens and Genotoxicity Assessment
- Health, Environment, Cognitive Aging
- Pharmacogenetics and Drug Metabolism
- Structural Analysis of Composite Materials
- Toxic Organic Pollutants Impact
- Climate Change and Health Impacts
Wageningen University & Research
2019-2024
Within the Human Biomonitoring for Europe initiative (HBM4EU), a study to determine new biomarkers of exposure pesticides and assess patterns was conducted. urine samples (N = 2,088) were collected from five European regions in two different seasons. The objective identify their metabolites with harmonized suspect screening approach based on liquid chromatography coupled high resolution mass spectrometry (LC-HRMS) applied laboratories. A combined data processing workflow included...
Abstract Human intestinal organoids (HIOs) are a promising in vitro model consisting of different cell types with 3D microarchitecture resembling native tissue. In the current study, we aimed to assess expression most common CYP enzymes human induced pluripotent stem (hiPSC)-derived HIO model, and suitability that study chemical-induced changes activity. We compared this commonly used colonic adenocarcinoma line Caco-2 primary epithelial (IEC)-based closely vivo optimized an existing...
Indoor dust has been postulated as an important matrix for residential pesticide exposure. However, there is a lack of information on presence, concentrations and determinants multiple pesticides in homes close to treated fields. Our objective was characterize the spatial temporal variance house dust, study use doormats floors proxies indoor identify occurrence concentrations. Homes within 250 m from selected bulb fields were invited participate. 20 km these but not having agricultural 500...
A set of quality assurance/quality control (QA/QC) criteria for nontargeted measurement pesticide exposure markers in a large-scale study human urine has been proposed and applied across five laboratories within the HBM4EU project. Quality material, including reference standards fortified pooled samples (QC urine) were prepared centralized way distributed participants to monitor analytical performance consistency liquid chromatography coupled high-resolution mass spectrometry data generated...
Liquid chromatography combined with high-resolution mass spectrometry (LC-HRMS) is a frequently applied technique for suspect screening (SS) and non-target (NTS) in metabolomics environmental toxicology. However, correctly identifying compounds based on SS or NTS approaches remains challenging, especially when using data-independent acquisition (DIA). This study assessed the performance of four HRMS-spectra identification tools to annotate in-house generated data-dependent (DDA) DIA HRMS...
Abstract Human biomonitoring can add value to chemical risk assessment by reducing the assumptions regarding consumption rates, residue occurrence, and processing effects integrating exposures from different sources (diet, household use, environmental). However, relationship between exposure concentration in human matrices is unknown for most pesticides. Therefore, we conducted a pilot study gain more insight into qualitative quantitative dietary intake of pesticides (external exposure)...
Abstract Reared insects such as black soldier fly larvae ( Hermetia illucens ) are considered a potential alternative feed protein. However, dietary exposure to insecticide residues via the substrate could adversely affect performance indicators (yield/survival) and substance-transfer from larval biomass result in non-compliance with low legal limits. Effects of pyrethroid insecticides cypermethrin deltamethrin were tested at varying concentrations, or without synergist piperonyl butoxide...
AND OBJECTIVES: Non-occupational sources of pesticide exposure may include domestic usage, diet, occupational household members, and agricultural activities in the residential area. We conducted a study with ambition to characterize mixture patterns sample adult population Netherlands Switzerland, using suspect screening approach identify related determinants. A total 105 295 adults participated Dutch Swiss studies, respectively. First morning void urine samples were collected analyzed same...
Monitoring strategies for veterinary drugs in products of animal origin are shifting towards a more risk-based approach. Such not only target limited number predefined .substances but also facilitate detection unexpected substances. By combining the use archive matrices such as feather meal with suspect-screening methods, early new hazards food and feed industry can be achieved. Effective application is hampered by complex data interpretation therefore, targeted analysis commonly applied. In...
The presence of carcinogenic aflatoxins in food and feed is a major issue. In prior studies, aflatoxin B1 (AfB1) known primary metabolites were absent from Lesser Mealworm (LMW, Alphitobius diaperinus) reared on contaminated diets. LMW promising alternative protein source. objectives this stu\dy to determine whether can be AfB1-contaminated each life-stage, gather more insight into potential formed. Results suggested no adverse effects terms survival/growth when three stages (larvae,...
TPS 623: Exposures to pesticides, Johan Friso Foyer, Floor 1, August 26, 2019, 3:00 PM - 4:30 Approximately 30% of Dutch homes are located within 250 meters agricultural fields. Concerns have been raised about the exposures residents from these pesticides. A possible source exposure being contamination indoor dust. Due lack information on levels in close fields, pesticides where measured dust newly placed clean doormats (ddm) and vacuumed floor (vfd). Homes m bulb fields were invited...
Indoor dust has been postulated as an important matrix for residential pesticide exposure. However, there is a lack of information on presence, concentrations and determinants multiple pesticides in homes close to treated fields. Our objective was characterize the spatial temporal variance house dust, study use doormats floors proxies indoor identify occurrence dust. Homes within 250 m from selected bulb fields were invited participate. 20 km these but not having agricultural 500 controls....
TPS 623: Exposures to pesticides, Johan Friso Foyer, Floor 1, August 26, 2019, 3:00 PM - 4:30 Backround/Aims. A large number of pesticides are applied in vineyards; exposure these chemicals occur farmers and the general population living near treated crops. This work aimed investigate cumulative using hair as a matrix for biomonitoring. Methods. Twenty agricultural workers 4 worker relatives took part study. Hair samples were collected before after application season. Agricultural recorded...