A5066635027- Fatty Acid Research and Health
- Contact Dermatitis and Allergies
- Eicosanoids and Hypertension Pharmacology
- Effects and risks of endocrine disrupting chemicals
- Peroxisome Proliferator-Activated Receptors
- Animal testing and alternatives
- Carcinogens and Genotoxicity Assessment
- Metabolism and Genetic Disorders
- Neuroscience and Neuropharmacology Research
- Marine Biology and Environmental Chemistry
- Metabolomics and Mass Spectrometry Studies
- Cholesterol and Lipid Metabolism
- Diet and metabolism studies
- Immunotoxicology and immune responses
- Inflammatory mediators and NSAID effects
- Adipose Tissue and Metabolism
- Food Allergy and Anaphylaxis Research
- Pesticide Exposure and Toxicity
- Toxic Organic Pollutants Impact
- Neuroinflammation and Neurodegeneration Mechanisms
- Lipid metabolism and biosynthesis
- Immune Response and Inflammation
- Biochemical Analysis and Sensing Techniques
- Antiplatelet Therapy and Cardiovascular Diseases
- Environmental Toxicology and Ecotoxicology
University of Milan
2015-2024
United States Consumer Product Safety Commission
2016-2022
Avantea
2011-2018
European Commission
2017
University of Bologna
1969-2015
Mylan (Switzerland)
2001-2015
Istituto di Scienze Marine del Consiglio Nazionale delle Ricerche
2004-2009
Institute of Structure of Matter
2007-2009
NATO Centre for Maritime Research and Experimentation
2009
Institute of Pharmacology
1978-2008
Interleukin (IL)-1β is a proinflammatory cytokine implicated in various pathophysiological conditions of the CNS involving NMDA receptor activation. Circumstantial evidence suggests that IL-1β and receptors can functionally interact. Using primary cultures rat hippocampal neurons, we investigated whether affects function(s) by studying (1) receptor-induced [Ca 2+ ] i increase (2) NMDA-mediated neurotoxicity. IL1β (0.01-0.1 ng/ml) dose-dependently enhances NMDA-induced increases with maximal...
Abstract —Essential fatty acid (EFA) deficiency initiated in rats prior to birth and continued for one year affects brain lipids an extent which differs the two sexes. It was found that: (1) Brain weight lipid content were decreased deficient conditions, especially males. (2) Total phospholipids present lower concentrations, particularly male brain, while percentage of major phospholipid classes‐ethanolamine phosphoglyceride (EPG), choline (CPG) serine (SPG) did not change. (3) EPG, CPG SPG...
The EFSA Panel on Contaminants in the Food Chain (CONTAM) established a tolerable daily intake (TDI) for fumonisin B
Cow's milk allergy is quite frequent in the first years of human life. When breast-feeding not possible, a cow's substitute must be provided for allergic subjects. Different alternatives to have been suggested as protein sources (soy, hydrolysed proteins, goat's milk, etc.), but all these dietetic solutions are without risks polyallergic or more sensitive subjects.To obtain new information on suitability other mammalian milks children, we evaluated cross-reactivity between proteins from...
Patulin is a mycotoxin produced by certain species of Penicillium and Aspergillus, often detectable in mouldy fruits their derivatives. On the basis PMTDI 0.4 microgram/kg bw, limit values 50 micrograms/kg or micrograms/l patulin have been set fruit To estimate quantity that can be taken with diet, we analysed HPLC samples apples apple derivatives which are most likely to contaminated patulin. In juices homogenized baby-foods, concentration was always below established limits, while some...
Abstract Erythropoietin, the principal regulator of erythroids progenitor cells, also promotes neuronal survival. Using primary cultures rat hippocampal neurons, we investigated whether erythropoietin could mediate neuroprotection favouring transcription brain‐derived neurotrophic factor (BDNF). Erythropoietin 2.7 n m reduced by ∼ 50% death triggered prototypic neurotoxicant trimethyltin (TMT) and time‐dependently induced BDNF mRNA. This effect resulted in an increased production...