A5025884837- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
- Pomegranate: compositions and health benefits
- Malaria Research and Control
- Phytochemical compounds biological activities
- Nuts composition and effects
- Medicinal Plant Research
- Phytochemistry and Biological Activities
- Edible Oils Quality and Analysis
- Cannabis and Cannabinoid Research
- Cholesterol and Lipid Metabolism
- Horticultural and Viticultural Research
- Antioxidant Activity and Oxidative Stress
- Natural Products and Biological Research
- Natural Antidiabetic Agents Studies
- Protease and Inhibitor Mechanisms
- Toxin Mechanisms and Immunotoxins
- Traditional and Medicinal Uses of Annonaceae
- Tannin, Tannase and Anticancer Activities
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Bioactive Compounds
- Helicobacter pylori-related gastroenterology studies
- Wound Healing and Treatments
- Insect Pest Control Strategies
University of Milan
2016-2025
Instituto de Histología y Embriología de Mendoza
2022
Consejo Nacional de Investigaciones Científicas y Técnicas
2022
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
2022
University of Padua
2022
Icesi University
2022
Mylan (Switzerland)
2015-2019
Milano University Press
2015
Pharmac
2010
Università di Camerino
2009
Cultured primary human keratinocytes are frequently employed for studies of immunological and inflammatory responses; however, interpretation experimental data may be complicated by donor to variability, the relatively short culture lifetime, variations between passages. To standardize in vitro on keratinocytes, we investigated use HaCaT cells, a long-lived, spontaneously immortalized keratinocyte line which is able differentiate , as suitable model follow release repair mediators response...
Plant extracts traditionally used for male impotence (Tribulus terrestris, Ferula hermonis, Epimedium brevicornum, Cinnamomum cassia), and the individual compounds cinnamaldehyde, ferutinin, icariin, were screened against phosphodiesterase-5A1 (PDE5A1) activity. Human recombinant PDE5A1 was as enzyme source. Only E. brevicornum extract (80% inhibition at 50 microg/mL) its active principle icariin (1) (IC50 5.9 microM) active. To improve inhibitory activity, 1 subjected to various structural...
Ellagitannins have shown anti-inflammatory and anti-Helicobacter pylori properties; however, their activity at gastric level was not previously investigated. The aim of this research to evaluate the effects ellagitannins from Rubus berries on inflammation. Ellagitannin enriched extracts (ETs) were prepared fruticosus L. (blackberry) idaeus (raspberry). tested cell line AGS stimulated by TNF-α IL-1β for evaluating effect NF-kB driven transcription, nuclear translocation IL-8 secretion. In...
Skin inflammatory diseases result from complex events that include dysregulation and abnormal expression of mediators or their receptors in skin cells. The present study investigates the potential effect a Cannabis sativa L. ethanolic extract standardized cannabidiol as antiinflammatory agent skin, unraveling molecular mechanisms human keratinocytes fibroblasts. inhibited release inflammation involved wound healing processes occurring skin. mode action impairment nuclear factor‐kappa B...
The Mediterranean diet reduces the risk of coronary artery disease as a consequence its high content antioxidants, namely, hydroxytyrosol (HT) and oleuropein aglycone (OleA), typical virgin olive oil. Because intercellular vascular cell adhesion molecules (ICAM-1 VCAM-1) E-selectin are crucial for endothelial activation, role phenolic extract from extra oil (OPE), OleA, HT, homovanillyl alcohol (HVA) on surface mRNA expression in human umbilical cells (HUVEC) was evaluated. OPE strongly...
The sun-dried rind of the immature fruit pomegranate (Punica granatum) is presently used as a herbal formulation (OMARIA, Orissa Malaria Research Indigenous Attempt) in Orissa, India, for therapy and prophylaxis malaria. pathogenesis cerebral malaria, complication infection by Plasmodium falciparum, an inflammatory cytokine-driven disease associated to up-regulation activity metalloproteinase-9 increase TNF production. vitro anti-plasmodial Punica granatum (Pg) was recently described. aim...
Fresh grapes contain phenolic compounds that have shown to exert antioxidant and anti-inflammatory activities at gastric level.
Cutibacterium acnes (C. acnes) is recognized as one of the main triggers cutaneous inflammatory response in acne vulgaris, a chronic skin disorder with multifactorial origin. Witch hazel (Hamamelis virginiana L.) plant widely used for conditions, some preliminary anti-inflammatory evidence on skin, but lacking data conditions. This study aimed to evaluate effect glycolic extract from Hamamelis bark (HVE) versus C. acnes-induced inflammation human keratinocytes (HaCaT). Phytochemical...
Helicobacter pylori (H. pylori) is an etiologic factor of peptic ulcer disease and gastric cancer. Virulent strains H. are correlated with the severity gastritis, due to NF-κB activation IL-8 expression at epithelial level. Ellagitannins have been documented for antibacterial anti-inflammatory activities, thus suggesting their potential use in gastritis. Recently, several authors, including our group, demonstrated that tannin-rich extracts from chestnut byproducts, present considered...
A high number of varieties from corn (Zea mays L.) have been consumed for long time all over the world, however pigmented are recently gaining renewed attention due to their beneficial effects and polyphenolic content. The natural lack gluten makes suitable consumption by celiac population, who need control inflammatory state through an appropriate gluten-free diet. biological polyphenols poorly investigated in context disease. In this work, we analyzed HPLC-DAD phenolic composition two...
The aim of the present study was to confirm that olive oil phenols reduce human platelet aggregability and verify hypothesis cAMP- cGMP- phosphodiesterases (PDE) could be one targets biological effect. Four extracts from oils characterized by a high phenol content (HPE), low levels (LPE) were prepared analyzed quali- quantitatively HPLC-UV electrospray ionization–MS/MS. Human washed platelets stimulated with thrombin used for aggregation assay. cAMP-PDE recombinant PDE5A1 as enzyme source....
We describe here an innovative, non-transgenic animal model of Alzheimer's disease. This mimics early stages sporadic disease, which represents the vast majority cases. The was obtained by interfering with complex between a disintegrin and metalloproteinase domain containing protein 10 (ADAM10), main α-secretase candidate, its partner, synapse-associated 97, postsynaptic density-membrane associated guanylate kinase family. Association ADAM10 97 governs enzyme trafficking activity at...
In vivo studies suggest that the phenolic component contributes to anti-inflammatory and antiatherosclerotic actions of olive oil; however, effects in circulating cells are not fully characterized. Monocytes play a key role inflammation-based diseases by expressing several molecules, including metalloproteinases (MMPs). present study, we investigated oil extract individual compounds on MMP-9 THP-1 cells, human monocyte-like cell line. Olive prevented stimulation expression secretion tumor...
<italic>Vitis vinifera</italic>L. water extract from dried leaves maintains its anti-inflammatory activity after<italic>in vitro</italic>gastric digestion.