A5038537226- Phytochemicals and Antioxidant Activities
- Natural product bioactivities and synthesis
- Essential Oils and Antimicrobial Activity
- Nuts composition and effects
- Cannabis and Cannabinoid Research
- Contact Dermatitis and Allergies
- Natural Products and Biological Research
- Pomegranate: compositions and health benefits
- Toxin Mechanisms and Immunotoxins
- Wound Healing and Treatments
- Dermatology and Skin Diseases
- Microbial Metabolites in Food Biotechnology
- Helicobacter pylori-related gastroenterology studies
- Medicinal Plant Research
- Colorectal Cancer Surgical Treatments
- Hops Chemistry and Applications
- Allergic Rhinitis and Sensitization
- Horticultural and Viticultural Research
- Urticaria and Related Conditions
- Advanced Chemical Sensor Technologies
- Colorectal and Anal Carcinomas
- Tannin, Tannase and Anticancer Activities
- Fermentation and Sensory Analysis
- Powdery Mildew Fungal Diseases
- Edible Oils Quality and Analysis
University of Milan
2015-2024
Pontifícia Universidade Católica do Rio Grande do Sul
2024
Ospedali Riuniti di Ancona
2005-2023
Instituto de Histología y Embriología de Mendoza
2022
Consejo Nacional de Investigaciones Científicas y Técnicas
2022
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
2022
University of Padua
2022
Icesi University
2022
Faculdade de Tecnologia e Ciências
2020
Mylan (Switzerland)
2015-2019
Cultured primary human keratinocytes are frequently employed for studies of immunological and inflammatory responses; however, interpretation experimental data may be complicated by donor to variability, the relatively short culture lifetime, variations between passages. To standardize in vitro on keratinocytes, we investigated use HaCaT cells, a long-lived, spontaneously immortalized keratinocyte line which is able differentiate , as suitable model follow release repair mediators response...
Skin inflammatory diseases result from complex events that include dysregulation and abnormal expression of mediators or their receptors in skin cells. The present study investigates the potential effect a Cannabis sativa L. ethanolic extract standardized cannabidiol as antiinflammatory agent skin, unraveling molecular mechanisms human keratinocytes fibroblasts. inhibited release inflammation involved wound healing processes occurring skin. mode action impairment nuclear factor‐kappa B...
Fresh grapes contain phenolic compounds that have shown to exert antioxidant and anti-inflammatory activities at gastric level.
Cutibacterium acnes (C. acnes) is recognized as one of the main triggers cutaneous inflammatory response in acne vulgaris, a chronic skin disorder with multifactorial origin. Witch hazel (Hamamelis virginiana L.) plant widely used for conditions, some preliminary anti-inflammatory evidence on skin, but lacking data conditions. This study aimed to evaluate effect glycolic extract from Hamamelis bark (HVE) versus C. acnes-induced inflammation human keratinocytes (HaCaT). Phytochemical...
Helicobacter pylori (H. pylori) is an etiologic factor of peptic ulcer disease and gastric cancer. Virulent strains H. are correlated with the severity gastritis, due to NF-κB activation IL-8 expression at epithelial level. Ellagitannins have been documented for antibacterial anti-inflammatory activities, thus suggesting their potential use in gastritis. Recently, several authors, including our group, demonstrated that tannin-rich extracts from chestnut byproducts, present considered...
A high number of varieties from corn (Zea mays L.) have been consumed for long time all over the world, however pigmented are recently gaining renewed attention due to their beneficial effects and polyphenolic content. The natural lack gluten makes suitable consumption by celiac population, who need control inflammatory state through an appropriate gluten-free diet. biological polyphenols poorly investigated in context disease. In this work, we analyzed HPLC-DAD phenolic composition two...
<h3>Objective.</h3> —To assess prospectively the impact on survival and health-related quality of life two follow-up protocols in patients with early breast cancer. <h3>Design.</h3> —Randomized controlled clinical trial. <h3>Setting.</h3> —Multicenter study involving 26 general hospitals Italy. <h3>Patients.</h3> —A consecutive sample 1320 women younger than 70 years stage I, II, III unilateral primary <h3>Intervention.</h3> —Patients were randomly assigned to an intensive surveillance,...
We analysed the expression of microsatellite instability, p53, p21, vascular endothelial growth factor and thymidylate synthase (TS) in pretreatment biopsy specimens from 57 locally advanced rectal cancers. The aim study was to correlate these markers with pathological response. Nineteen patients were treated preoperative concomitant radiotherapy (RT) fluorouracil/oxaliplatin-based chemotherapy (RCT), while 38 had RT alone. Pathological complete remission (pCR) microfoci residual tumour...
<italic>Vitis vinifera</italic>L. water extract from dried leaves maintains its anti-inflammatory activity after<italic>in vitro</italic>gastric digestion.
A wide range of people in the world use natural remedies as primary approaches against illnesses. Accordingly, understanding mechanisms action phytochemicals has become great interest. In this context, Centella asiatica L. is extensively used, not only anti-inflammatory or antioxidant agent but also brain tonic. On basis, purpose study was to evaluate whether chronic administration C. adult male rats able improve expression Bdnf, one main mediators plasticity. Moreover, we assessed treatment...
Raisins (Vitis vinifera L.) are dried grapes largely consumed as important source of nutrients and polyphenols. Several studies report health benefits raisins, including anti-inflammatory antioxidant properties, whereas the activity at gastric level hydro-alcoholic extracts, which mostly used for food supplements preparation, was not reported until now. The aim this study to compare five raisin extracts focusing on Interleukin (IL)-8 Nuclear Factor (NF)-κB pathway. Raisin were characterized...
Psoriasis is a chronic cutaneous condition characterized by the release of pro-inflammatory mediators and oxidative stress. The reduction these factors currently most effective strategy to inhibit symptoms pathology. Antioxidants from natural sources are increasingly used improve skin conditions. Dried red leaves grapevine (Vitis vinifera L., cv Teinturiers) showed anti-inflammatory anti-bacterial activities, but their possible effects on keratinocytes have not been previously investigated....
Atherosclerosis is characterized by interaction between immune and vascular endothelial cells which mediated adhesion molecules occurring on the surface of endothelium leading to massive release proinflammatory mediators.
In Cameroon, local plants are traditionally used as remedies for a variety of ailments. this regard, several papers report health benefits Cameroonian spices, which include antioxidant and anti-microbial properties, whereas gastric anti-inflammatory activities have never been previously considered. The present study investigates the hydro-alcoholic extracts eleven spices in epithelial cells (AGS GES-1 cells). showed properties cell-free system reduced H2O2-induced ROS generation cells. After...
Sumac (Rhus coriaria L.) is a spice and medicinal herb traditionally used in the Mediterranean region Middle East. Since we previously demonstrated biological activity model of tumor necrosis factor alpha (TNF-α)-induced skin inflammation, present work aimed at further demonstrating potential role inflammatory disorders, focusing on gastritis. For this purpose, different polar extracts (water-W, ethanol-water-EW, ethanol-E, ethanol macerated-Em, acetone-Ac, ethylacetate-EtA) were...
Hamamelis virginiana L. bark extract is a traditional remedy for skin affections, including atopic dermatitis/eczema (AD). preparations contain tannins, hamamelitannin (HT), although their pharmacological role in AD still unknown. This study aimed to the rational its topical use by considering impact of crucial biomarkers on pathogenesis. A standardized (HVE) (0.5−125 μg/mL) was compared main compound (0.5−5 μg/mL), model human keratinocytes (HaCaTs), challenged with an AD-like cytokine...
Acne vulgaris is a prevalent skin disorder affecting many young individuals, marked by keratinization, inflammation, seborrhea, and colonization Cutibacterium acnes (C. acnes). Ellagitannins, known for their antibacterial anti-inflammatory properties, have not been widely studied anti-acne effects. Chestnut (Castanea sativa Mill., C. sativa), rich ellagitannin source, including castalagin whose acne-related bioactivity was previously unexplored, investigated in this study. The research...
In this study, we investigated the ability of a phenolic extract from extra virgin olive oil (OPE) to modulate inflammatory response in intestinal epithelial cells. Undifferentiated and differentiated Caco-2 cells were challenged with LPS (50 μg/mL) or IL-1β (5 ng/mL) mimic early intermediate phase inflammation, respectively. The effects OPE on nuclear factor-κB-driven transcription IL-8 promoter activity evaluated transfection assays, coupled p65 translocation. Modulation mRNA levels by was...
Wound healing is a complex process regulated by multiple signals and consisting of several phases known as haemostasis, inflammation, proliferation, remodelling. Keratinocytes, endothelial cells, macrophages, fibroblasts are the major cell populations involved in wound process. Hypoxia plays critical role this since cells sense respond to hypoxic conditions changing gene expression. This study assessed vitro expression 77 genes angiogenesis, metabolism, growth, proliferation apoptosis human...
Inflammation and oxidative stress are two mechanisms involved in the pathogenesis of celiac disease (CD). Since direct effect gliadin on intestinal epithelia is less studied, aims this study were development a specific cellular model based use as pro-inflammatory stimulus evaluation potential antioxidant anti-inflammatory properties extracts from different black rice framework CD. The vitro digested, characterized terms phenolic compounds capacity, tested Caco-2 cells to investigate their...