A5017977476- Cerebrovascular and Carotid Artery Diseases
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- COVID-19 Clinical Research Studies
- Research on Leishmaniasis Studies
- SARS-CoV-2 and COVID-19 Research
- Mosquito-borne diseases and control
- Malaria Research and Control
- Electrospun Nanofibers in Biomedical Applications
- Long-Term Effects of COVID-19
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Advanced Nanomaterials in Catalysis
- Mesenchymal stem cell research
- Physiological and biochemical adaptations
- vaccines and immunoinformatics approaches
- Respiratory Support and Mechanisms
- Systemic Lupus Erythematosus Research
- Erythrocyte Function and Pathophysiology
- Hydrogen's biological and therapeutic effects
- Microbial Metabolism and Applications
- Diabetic Foot Ulcer Assessment and Management
- Inflammasome and immune disorders
- Thermal Regulation in Medicine
- Chromosomal and Genetic Variations
University of Milan
2018-2024
IRCCS Policlinico San Donato
2022
Abstract Background The systemic inflammatory syndrome called “cytokine storm” has been described in COVID-19 pathogenesis, contributing to disease severity. analysis of cytokine and chemokine levels the blood 21 SARS-CoV-2 positive patients throughout phases pandemic studied understand immune response dysregulation identify potential biomarkers for new treatments. present work reports sera from a small cohort individuals primarily infected with during first wave Milan (Italy). Results Among...
Introduction: Human Endogenous RetroViruses (HERVs) account for approximately 8% of the human genome, where they are integrated and typically remain silent. Despite their inactivation, numerous retroviral sequences retain intact open reading frames (ORFs) capable producing transcripts and/or proteins, which have been detected in colon cancer. Methods: Three different cohorts patients who underwent surgery at three hospitals, comprising 167 Italian Tunisian cancer patients, were analyzed. The...
Wound healing is a complex process regulated by multiple signals and consisting of several phases known as haemostasis, inflammation, proliferation, remodelling. Keratinocytes, endothelial cells, macrophages, fibroblasts are the major cell populations involved in wound process. Hypoxia plays critical role this since cells sense respond to hypoxic conditions changing gene expression. This study assessed vitro expression 77 genes angiogenesis, metabolism, growth, proliferation apoptosis human...
In the novel pandemic of Coronavirus Disease 2019, high levels pro-inflammatory cytokines lead to endothelial activation and dysfunction, promoting a pro-coagulative state, thrombotic events, microvasculature injuries. The aim present work was investigate effect SARS-CoV-2 on cytokines, tissue factor, chemokine release, with Human Microvascular Endothelial Cells (HMEC-1). ACE2 receptor expression evaluated by western blot analysis. infection assessed one-step RT-PCR until 7 days...
Abstract Background The innate immune response against various life cycle stages of the malaria parasite plays an important role in protection disease and regulation its severity. Phagocytosis asexual erythrocytic is well documented, but little contrasting results are available about phagocytic clearance sexual stages, gametocytes, which responsible for transmission parasites from humans to mosquitoes. Similarly, activation host macrophages by gametocytes has not yet been carefully...
Abstract Haemozoin is a by-product of haemoglobin digestion by intraerythrocytic malaria parasites, which induces immunologic responses on different tissues, including endothelial cells. In the present paper, incubation human microvascular cells with haemozoin significantly inhibited MTT reduction, measure cytotoxicity, without increasing release cytoplasmic lactate dehydrogenase. Moreover, did not induce apoptosis or cell cycle arrest nor decreased number live cells, suggesting that...