A5063665446- Health Systems, Economic Evaluations, Quality of Life
- Infectious Diseases and Tuberculosis
- Respiratory and Cough-Related Research
- Diphtheria, Corynebacterium, and Tetanus
- Bacterial Infections and Vaccines
- Hematological disorders and diagnostics
- Neonatal Respiratory Health Research
- Global Health Care Issues
- Pneumocystis jirovecii pneumonia detection and treatment
- Intramuscular injections and effects
- Botulinum Toxin and Related Neurological Disorders
- COVID-19 Clinical Research Studies
- Adrenal Hormones and Disorders
- Kawasaki Disease and Coronary Complications
- Pharmaceutical Economics and Policy
- Viral Infections and Immunology Research
- Cardiac pacing and defibrillation studies
- Herbal Medicine Research Studies
- Infections and bacterial resistance
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- Immune Response and Inflammation
- Radiopharmaceutical Chemistry and Applications
- Biomedical Ethics and Regulation
- Myasthenia Gravis and Thymoma
Manchester University NHS Foundation Trust
2024
Bocconi University
2015-2023
Newcastle University
2019
European Society of Cardiology
2015
Imperial College London
2005-2009
University of Oxford
2009
Leatherhead Food Research
1963
West Park Hospital
1933-1954
Marie Curie Hospice
1952
Public Health Laboratory
1950
IFNs lambda1, lambda2, and lambda3, or type III IFNs, are recently identified cytokines distantly related to I IFNs. Despite an early evolutionary divergence, the 2 types of display similar antiviral activities, both produced primarily in dendritic cells. Although virus induction IFN-beta gene had served as a paradigm regulation, relatively little is known about regulation IFN-lambda expression. Studies IFN-lambda1 essential role IFN regulatory factors (IRF) 3 7, which bind DNA sequence near...
The objective of this paper was to compare health outcomes and hospital care use very low birth weight (VLBW), preterm (VLGA) infants in seven European countries. Analysis performed on linkable patient-level registry data from countries between 2006 2008 (Finland, Hungary, Italy (the Province Rome), the Netherlands, Norway, Scotland, Sweden). Mortality length stay (LoS) were adjusted for differences gestational age (GA), sex, intrauterine growth, Apgar score at five minutes, parity multiple...
More than 230 million women live with FGM/C worldwide, a condition linked to adverse health consequences, and for which the quality of available care is often inadequate. As it hard identify reach migrant living in host countries, research on this population group Europe limited. This paper focuses Italian context. The aim investigate probability immigrants coming from countries where practiced be hospitalised FGM/C-related obstetrical issues, using data Hospital Discharge Records year 2019....
The incidence of Gestational Diabetes Mellitus (GDM) is rising in all developed countries. This study aimed at assessing the short-term economic burden GDM from Italian healthcare system perspective.A model was built over last pregnancy trimester (i.e., 28th gestational week until childbirth included). National Hospital Discharge Database (2014) accessed to estimate delivery outcome probabilities and inpatient costs normal pregnancies euglycemia). International Classification Disease-9th...
Differing contexts have greatly influenced HTA development in various countries, with considerable effort recently made by international networks (e.g., EUnetHTA) and the European Union (EU) to make a more coherent, equal, efficient process. Medical devices (MDs) present particular challenges for because of frequent, rapid innovation, outcomes end-user competence, dynamic pricing often low-quality scientific evidence. Our objective is describe development, structure governance National...
Introduction The new European Union (EU) Regulations for medical devices (MDs) and health technology assessment (HTA) are welcome developments that should increase the quality of clinical evidence MDs reduce fragmentation in EU market access process. To fully exploit anticipated benefits, their respective processes be closely coordinated, particularly promising, highly innovative MDs. Accelerated approval is worth exploring certain categories high-risk to keep regulatory process competitive...
Abstract Despite established efficacy for cardiac implantable electrical devices (CIEDs), large differences in CIED implant rates have been documented across and within countries. The aim of this paper is to investigate the influence socio‐economic, epidemiological supply side factors on 57 Regions 5 EU countries assess feasibility using administrative data purpose. A total 1 330 098 hospitalizations procedures extracted from hospital discharge databases Austria, England, Germany, Italy...
Common methodologies for analysis of analogous data sets are needed international comparisons treatment and outcomes. This study tests using administrative hospital discharge (HD) databases in five European countries to investigate variation/trends pacemaker (PM) implantable cardioverter defibrillator (ICD) implant rates terms patient characteristics/management, device subtype, initial implantation vs. replacement, compares findings with existing literature Heart Rhythm Association (EHRA)...
Immigrants face multiple barriers in accessing healthcare; however, empirical assessment of access presents serious methodological issues, and evidence on undocumented immigrants is scant based mainly non-representative samples. We examine avoidable hospitalization (AH) as an indicator poor to primary care (PC) Italy, where a universal healthcare system guarantees but fails assign general practitioners immigrants.Using anonymized national hospital discharge records 2019, were identified...
Despite recent advances in medical therapies for inflammatory bowel disease [IBD], little is known about their impact on inpatient management. Our objectives were to explore hospitalisation and surgery trends all IBD patients Italy at three time points over 7 years.National hospital discharge records retrospectively reviewed admissions with a Crohn's [CD, 555*] or ulcerative colitis [UC, 556*] diagnosis 2005, 2008, 2011. Quantitative variables [mean, standard deviation] categorical...
Abstract Background The generation of large amounts microarray data presents challenges for collection, annotation, exchange and analysis. Although there are now widely accepted formats, minimum standards content ontologies data, only a few groups using them together to build populate large-scale databases. Structured environments management crucial making full use these data. Description MiMiR database provides comprehensive infrastructure storage is based on the MAGE format....
To explore the role of novel cardiac output response to stress (CORS), test in current diagnostic pathway for heart failure and opportunities challenges potential implementation primary care. Qualitative study using semistructured in-depth interviews which were audio recorded transcribed verbatim. Data from analysed thematically an inductive approach. Newcastle upon Tyne, UK. Fourteen healthcare professionals (six males, eight females) (general practitioners (GPs), nurses, assistant,...