A5041626117- Health Systems, Economic Evaluations, Quality of Life
- Sodium Intake and Health
- Blood Pressure and Hypertension Studies
- Innovation Policy and R&D
- Pharmaceutical Economics and Policy
- Hormonal Regulation and Hypertension
- Oral and gingival health research
- Medieval European Literature and History
- Bone and Dental Protein Studies
- BRCA gene mutations in cancer
- Glioma Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Theology and Canon Law Studies
- Management, Economics, and Public Policy
- Ovarian cancer diagnosis and treatment
- Pancreatic and Hepatic Oncology Research
- PARP inhibition in cancer therapy
- Delphi Technique in Research
- Neuroendocrine Tumor Research Advances
- Heart Failure Treatment and Management
- Cancer Cells and Metastasis
- Obstructive Sleep Apnea Research
- Periodontal Regeneration and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Medication Adherence and Compliance
Bocconi University
2018-2024
University of Catania
2023
Hospital Sírio-Libanês
2016
Fondazione Humanitas per la Ricerca
2007-2011
University of Milan
2005-2010
Istituto Ortopedico Galeazzi
2010
Morpho (United States)
2009
Istituto Nazionale di Fisica Nucleare, Laboratori Acceleratori e Superconduttività Applicata
2006
University of Bologna
1981-1993
Policlinico S.Orsola-Malpighi
1992-1993
1. The sodium concentration in lymphocytes was measured a group of 66 normotensive subjects (40 without familial hypertension and 26 with hypertension), 81 patients essential 14 secondary hypertension. 2. mean value (+/- SD) no history 21.9 +/- 3.1 mmol/kg wet weight, which significantly lower (P less than 0.005) that (mean 27.9 4.2 mmol/kg). Lymphocyte higher (33.2 3.3 mmol/kg; P 0.001) the normal blood pressure 3. In there significant correlation between lymphocyte systolic 0.005),...
Early access programs (EAPs) generally refer to patient medicines/indications before marketing authorization, possibly extended price and reimbursement approval. These include compassionate use, which is usually covered by pharmaceutical companies, EAPs reimbursed third-party payers. This paper aims at comparing in four European countries (France, Italy, Spain, UK) providing empirical evidence on Italy. The comparative analysis was conducted through a literature review (including scientific...
The effects of a moderate dietary salt restriction on intralymphocytic sodium content and pressor response to stress (mental arithmetic, handgrip, bicycle exercise) were tested in 25 young subjects with borderline hypertension. study was performed by randomized, cross-over, within-patient, experimental design. Diet did not significantly reduce blood pressure at rest but so both systolic diastolic during exercise. Variations induced stimulation correlated before low-salt diet whereas no...
Sperm protein 17 (Sp17) is a highly conserved mammalian characterized in rabbit, mouse, monkey, baboon, macaque, human testis and spermatozoa. mRNA encoding Sp17 has been detected range of murine somatic tissues. It was also recognized two myeloma cell lines neoplastic cells from patients with multiple ovarian carcinoma. These data all indicate that widely distributed humans, expressed not only germinal variety tissues, but unrelated origin. expression analyzed by immunocytochemistry...
Differing contexts have greatly influenced HTA development in various countries, with considerable effort recently made by international networks (e.g., EUnetHTA) and the European Union (EU) to make a more coherent, equal, efficient process. Medical devices (MDs) present particular challenges for because of frequent, rapid innovation, outcomes end-user competence, dynamic pricing often low-quality scientific evidence. Our objective is describe development, structure governance National...
Ovarian cancer (OC) is the eighth most common among women, and homologous recombination deficiency (HRD) present in approximately 50% of these patients. For this group, poly(ADP-ribose) polymerase (PARP) inhibitors are more likely to be effective. The aim study was investigate cost-effectiveness HRD testing versus BRCA (which identifies mutations only 25% patients) Italy optimize treatment management, possibly with PARP inhibitors. A partition survival model developed estimate expected costs...
The overall value of treatments for chronic lymphocytic leukemia (CLL) depends on several factors, including preferences the general population, who contributes to financing health systems. This study investigated societal attributes CLL in Italy. An online large-scale survey was designed using a discrete choice experiment (DCE) methodology and delivered Italian adult population. Ten treatment were identified, covering efficacy, safety, operational aspects (hypothetical) out-of-pocket cost....
This paper illustrates analysis of opinions collected from selected European payers (HTA organisations, authorities/committees assessing, appraising and negotiating drug prices) experts (researchers/consultants identified through LinkedIn groups) on price regulation, managed entry agreements, transparency HTA advice. Expert payer were gathered a structured questionnaire, validated by three potential respondents self-administered online between July November 2021. Respondents totalled 39...
Cerebral palsy (CP) is a nonprogressive central nervous system lesion clinically characterized by impairment of voluntary movement related to spasticity, time activation, and strength skeletal muscle. Altered muscular control may act on tendon structure influence extracellular matrix homeostasis, in particular, collagen. The effect spasticity collagen turnover CP patients' tendons has not been described previously. We studied genes the gracilis semitendinosus diplegic (n = 6) quadriplegic...
We characterized the effect of chronic ochratoxin A (OTA) on rat kidney cortex, analyzing collagen content and turnover major markers epithelial-to-mesenchymal transition (EMT), such as α-smooth muscle actin (αSMA), cadherins, MMP-9. Because OTA nephrotoxicity is mediated by free radicals, we also investigated whether antioxidants in red wine provided protection for attenuated OTA-induced EMT. Collagen content, determined computerized analysis Sirius red-stained sections, increased OTA,...
The NASA/American Cancer Society (ACS) flow cytometer can simultaneously analyze the electronic nuclear volume (ENV) and DNA content of cells. This study describes schematics, resolution, reproducibility, sensitivity biological standards analyzed on this unit.Calibrated beads (lymphocytes, trout erythrocytes [TRBC], calf thymocytes, tumor cells) were for ENV versus content. Parallel data (forward scatter DNA) from a conventional obtained.ENV linearity studies yielded an R value 0.999. TRBC...
1. A highly significant correlation between intralymphocytic sodium concentration and basal diastolic blood pressure can be found only in patients with sustained essential hypertension. 2. In subjects borderline hypertension normotensive familial a the increase induced by mental arithmetic or handgrip exercise. 3. The recorded during genetic is significantly greater if than 26 mmol/kg.
Glioblastoma is a highly malignant tumor, characterized by an unfavorable prognosis even in response to multidisciplinary treatment strategies, owing its high-invasive phenotype. Ukrain, semisynthetic thiophosphoric acid derivative of the purified alkaloid chelidonine, has been used therapy several solid tumors, but little known about effect on glioblastoma and, general, molecular mechanisms responsible for effects. In particular, we previously demonstrated that Ukrain modulates expression...
We investigated whether Ukrain modulates the malignant phenotype of clear cell renal carcinoma (ccRCC) cells Caki-1, Caki-2, and ACHN treated with four doses (5, 10, 20, 40 μmol/l) for 24 48 h. The epithelial-to-mesenchymal transition markers E-cadherin, β-catenin, vimentin were analyzed by immunofluorescence as well actin tubulin; matrix metalloproteinase-2 metalloproteinase-9 activity was SDS-zymography, intracellular secreted SPARC levels western blot, cycle flow cytometry. did not induce...
Major depressive disorder is considered one of the most frequent diseases in general population, and treatment-resistant depression (TRD) represents subset with more significant clinical social impact. Large, robust phase III studies have shown safety efficacy esketamine nasal spray plus SSRI/SNRI antidepressants (ADs) compared placebo patients TRD. The main aim this study was to perform a cost-utility analysis comparing ADs alone TRD patients, from societal perspective Italy. A secondary...
Abstract Background Asthma is a common chronic inflammatory airway affecting over 260 million people worldwide, and characterized, in the large majority of cases, by so-called “type 2 inflammation”. Fractional exhaled nitric oxide (FE NO ) testing noninvasive point-of-care tool to assess type inflammation therefore improve asthma management. It has been suggested determine eligibility for specific biologic therapy predict likelihood respond. The aim this study was estimate overall economic...