A5033177175- Redox biology and oxidative stress
- Sulfur Compounds in Biology
- Dialysis and Renal Disease Management
- Advanced Glycation End Products research
- Nanoparticles: synthesis and applications
- Alcohol Consumption and Health Effects
- Antioxidant Activity and Oxidative Stress
- Glutathione Transferases and Polymorphisms
- Protein Interaction Studies and Fluorescence Analysis
- Folate and B Vitamins Research
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Genomics, phytochemicals, and oxidative stress
- Biochemical effects in animals
- Air Quality and Health Impacts
- Environmental Toxicology and Ecotoxicology
- Advanced biosensing and bioanalysis techniques
- Hemoglobin structure and function
- Nitric Oxide and Endothelin Effects
- Advanced Nanomaterials in Catalysis
- Iron Metabolism and Disorders
- Diet and metabolism studies
- Animal Behavior and Reproduction
- Polyamine Metabolism and Applications
- Heme Oxygenase-1 and Carbon Monoxide
University of Milan
2016-2025
ASST Fatebenefratelli Sacco
2020
Neuroscience Institute
2015
National Research Council
2015
National Academies of Sciences, Engineering, and Medicine
2015
Charité - Universitätsmedizin Berlin
2013
Gruppo CLAS (Italy)
1986
Patients with end‐stage renal disease (ESRD) undergoing haemodialysis (HD) experience oxidative/carbonyl stress, which is postulated to increase after the HD session. The influence of diabetes mellitus and sex on oxidation plasma proteins in ESRD has not yet been clarified despite that diabetic nephropathy most common cause developed developing countries increasingly emerging differences between males females epidemiology, pathophysiology, clinical manifestations, outcomes for several...
Collagen-based skin-like scaffolds (CBSS) are promising alternatives to skin grafts repair wounds and injuries. In this work, we propose that the common marine invertebrate sea urchin represents a eco-friendly source of native collagen develop innovative CBSS for injury treatment. Sea food waste after gonad removal was here used extract fibrillar glycosaminoglycan (GAG)-rich produce bilayer (2D + 3D) CBSS. Microstructure, mechanical stability, permeability water proteins, ability exclude...
It is well known that copper oxide nanoparticles (CuO NPs) are heavily toxic on in vitro systems. In human alveolar epithelial cells, the mechanism of toxicity mostly related to oxidative insults, coming from intracellularly dissolved ions, finally leading apoptotic or autophagic cell death. Our hypothesis based possible early events specific NP surface reactivity able undermine integrity and drive death, independently Lysosomal-Enhanced Trojan Horse mechanism. Two types CuO NPs, with...
Cigarette smoking is a major risk factor for developing pulmonary and cardiovascular diseases as well some forms of cancer. Understanding the mechanisms by which contributes to disease remains research focus. Increased levels carbonylated serum proteins are present in smokers; albumin protein bronchoalveolar lavage fluid older smokers. We have investigated susceptibility human (HSA) α,β-unsaturated aldehyde-induced carbonylation when exposed whole-phase cigarette smoke extract (CSE)....
Pigmentation of body surface in animals can have multiple determinants and accomplish diverse functions. Eumelanin pheomelanin are the main animal pigments, being responsible yellow, brownish-red black hues, partly common biosynthetic pathways. Many populations vertebrates show individual variation melanism, putatively with large heritable component. Genes for eu- or pheomelanogenesis pleiotropic but contrasting effects on life-history traits, explaining patterns covariation observed between...
Background It is amply demonstrated that cigarette smoke (CS) has a high impact on lung tumor progression worsening cancer patient prognosis and response to therapies. Alteration of immune cell types functions in smokers’ lungs have been strictly related with detrimental effects. However, the role CS dictating an inflammatory or immunosuppressive microenvironment still needs be elucidated. Here, we investigated effect vitro exposure extract (CSE) focusing macrophages. Methods Immortalized...
Myotonic dystrophy type 1 (DM1) and 2 (DM2) are progressive multisystemic disorders caused by similar mutations at two different genetic loci. The common key feature of DM pathogenesis is nuclear accumulation mutant RNA which causes aberrant alternative splicing specific pre-mRNAs altering the functions binding proteins, MBNL1 CUGBP1. However, DM1 DM2 show disease-specific features that make them clearly separate diseases suggesting other cellular molecular pathways may be involved. In this...
Oxidative stress experienced during early development can negatively affect diverse life-history traits, and organisms have evolved complex defence systems against its detrimental effects. Bird eggs contain maternally derived exogenous antioxidants that play a major role in embryo protection from oxidative damage, including the negative effects on telomere dynamics. In this study yellow-legged gull ( Larus michahellis ), we manipulated concentration of vitamin E (VE) egg yolk analysed...