A5008479047- Polyomavirus and related diseases
- Reproductive tract infections research
- Full-Duplex Wireless Communications
- Reproductive System and Pregnancy
- Occupational and environmental lung diseases
- Antenna Design and Analysis
- Cervical Cancer and HPV Research
- Gut microbiota and health
- Tumors and Oncological Cases
- COVID-19 Impact on Reproduction
- HIV-related health complications and treatments
- Parvovirus B19 Infection Studies
- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Viral-associated cancers and disorders
- Urinary Tract Infections Management
- HIV Research and Treatment
- Pelvic floor disorders treatments
- Endometriosis Research and Treatment
- Preterm Birth and Chorioamnionitis
- Pleural and Pulmonary Diseases
- Multiple Sclerosis Research Studies
- Medical Imaging and Pathology Studies
- HIV/AIDS Research and Interventions
- Pregnancy and Medication Impact
IRCCS Materno Infantile Burlo Garofolo
2016-2025
University of Trieste
2010-2020
University of Ferrara
2020
Istituti di Ricovero e Cura a Carattere Scientifico
2011
Regarding bacterial vaginosis (BV), the relevance of vaginal microbiota to women's health fulfils a key role but knowledge gaps regarding aerobic vaginitis (AV) exist. This study aims characterize microbiome and its relationship with local immune mediators providing an opportunity define link between commensal microorganisms opportunistic pathogens in relation given community state type (CST). A total 90 samples from Caucasian asymptomatic women reproductive age (18y–40y) attending yearly...
The presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been recently demonstrated in the sputum or saliva, suggesting how shedding viral RNA outlasts end symptoms. Recent data from transcriptome analysis show that oral cavity mucosa harbors high levels angiotensin-converting enzyme (ACE2) and transmembrane protease, serine (TMPRSS2), highlighting its role as a double-edged sword for SARS-CoV-2 body entrance interpersonal transmission. Here, we studied microbiota...
The microbiota fulfils a key role in the training and function of immune system, which contributes to symbiosis between host complex microbial communities. In this study, we characterized interplay vaginal bacteria local mediators during dysbiosis selected women reproductive age who were grouped according Nugent's criteria. abundance Gardnerella vaginalis Bifidobacterium breve was increased intermediate dysbiotic status, while presence plethora non-resident group with overt vaginosis....
Abstract Background The systemic inflammatory syndrome called “cytokine storm” has been described in COVID-19 pathogenesis, contributing to disease severity. analysis of cytokine and chemokine levels the blood 21 SARS-CoV-2 positive patients throughout phases pandemic studied understand immune response dysregulation identify potential biomarkers for new treatments. present work reports sera from a small cohort individuals primarily infected with during first wave Milan (Italy). Results Among...
Abstract To explore the involvement of simian polyomavirus SV40 in human colon cancer, a molecular case–control study was undertaken patients and their relatives living an area where spread has already been documented. From 2006 to 2008, 94 cancer (age: 37–90 years) 91 subjects 32–70 each index case were enrolled. A blood sample specimen tissue or biopsy collected, from patient control, respectively. Samples analyzed twice for Polyomavirus (i.e., SV40, JCV, BKV) by PCR quantitative real‐time...
Background Asbestos-induced mesothelial inflammatory processes are thought to be the basic mechanisms underlying Malignant Mesothelioma (MM) development. Detection of MM often occurs at late stage due long and unpredictable latent period low incidence in asbestos exposed individuals. The aim this study was investigate early immunological biomarkers characterize prognostic profile a possible asbestos-induced disease, subjects from hyperendemic area. Methods Luminex Multiplex Panel Technology...
Altered miRNA expression is an early event upon exposure to occupational/environmental carcinogens; thus, identification of a novel asbestos-related profile miRNAs able distinguish asbestos-induced cancer from with different etiology can be useful for diagnosis. We therefore performed study identify associated malignancies.Four groups patients were included in the study, including (NSCLCAsb) and asbestos-unrelated non-small cell lung (NSCLC) or malignant pleural mesothelioma (MPM),...
Chronic psychosocial stress at workplace is an important factor in the development of physical and mental illness. Objective biological measures chronic are still lacking, but inflammatory response growth factors increasingly considered as potential biomarkers. Therefore, we investigated relationship between psychophysical strain serum levels 48 chemokines, cytokines measured using a multiplex immunoassay, brain-derived neurotrophic (BDNF) by ELISA. Severity was scored 115 healthy hospital...
Recent evidence has highlighted the role of gut–brain axis in progression autism spectrum disorder (ASD), with significant changes gut microbiome individuals this condition. This report investigates effects probiotics and human milk oligosaccharide (HMO) supplements on microbiome, inflammatory cytokine profile, clinical outcomes an ASD adolescent chronic gastrointestinal dysfunction cognitive impairment. Following treatment, we observed a decrease proinflammatory cytokines’ concentration...
Endometriosis (EM) is a chronic inflammatory disorder with multifactorial etiologies (i.e., genetics and environmental factors, hormonal immunological changes, microbiome alterations). The complement system one of the most frequently dysregulated pathways in EM. Mannose-binding lectin (MBL), carbohydrate pattern recognition molecule, first described subcomponent pathway (LP). Here, we unveiled interplay among MBL polymorphisms, plasma levels, LP functionality, microbiota as potential...
Abstract Polyomavirus infection occurring during childhood is followed by a lifelong latency in immunocompetent subjects. The major site of polyomavirus persistence are the uroepithelial cells which leads to oral transmission. It has recently been hypothesized that tonsils could be possible reservoir. role tonsil, adenoid, and peripheral blood mononuclear (PBMCs) as sites JCV, BKV, SV40 young healthy children was assessed. Two hundred fifteen fresh specimens, including 57 80 78 PBMC samples...
In recent years the incidence of male infertility has increased. Many risk factors have been taken into consideration, including viral infections. Investigations agents and mainly focused on human papillomaviruses, while no reports published polyomaviruses infertility. The aim this study was to verify whether JC virus BK are associated with Matched semen urine samples from 106 infertile males 100 fertile males, as controls, were analyzed. Specific PCR analyses carried out detect quantify...
Background The causal interpretation of cervical immune response to Human Papillomavirus (HPV) infection is complex and poorly characterized mainly due the delicate balance that exists between viral infection, increase inflammatory cytokines host risk factors. This study aims explore significance mediators associated cell survival, angiogenesis interaction with response, in predicting develop HPV-related intraepithelial lesions. Methods A panel 48 growth factors were explored a selected...
Chronic inflammatory response is one of major contributors in the development hepatocellular carcinoma (HCC). Inflammatory molecules, such as cytokines and growth factors circulation, can be useful diagnosis prognosis patients. The stem cell factor beta (SCGFβ), a newly found protein, secreted sulfated glycoprotein it functions for primitive hematopoietic progenitor cells. level SCGFβ had been reported to elevated several cancer types. However, there very few or even no information on this...
Malignant pleural mesothelioma (MPM) is an aggressive tumour resistant to treatments. It has been postulated that cancer stem cells (CSCs) persist in tumours causing relapse after multimodality treatment. In the present study, a novel miRNA-based therapy approach proposed. MPM-derived spheroids have treated with exosome-delivered miR-126 (exo-miR) and evaluated for their anticancer effect. The exo-miR treatment increased MPM stem-cell like stemness inhibited cell proliferation. However, at...
Cerebrospinal fluid (CSF) analysis in patients with particular neurologic disorders is a powerful tool to evaluate specific central nervous system inflammatory markers for diagnostic needs, because CSF represents the immune micro-environment system.CSF samples from 49 multiple sclerosis (MS), chronic demyelinating polyneuropathy (CIDP), and non-inflammatory (NIND) as controls were submitted protein expression profiles of 47 biomarkers by multiplex Luminex bead assay investigate possible...
The sterile-womb dogma in uncomplicated pregnancy has been lively debated. Data regarding the utero microbiome environment are based mainly on studies performed at time of delivery. Aim: To determine whether human placenta and amniotic fluid populated by a bacterial microbiota first second trimesters pregnancy. Materials & methods: We analyzed next-generation sequencing method 24 29 samples from chorionic villus sampling (CVS) amniocentesis (AC), respectively. V3 region 16S rRNA gene was...
The in utero microbiome hypothesis has been long debated. This will change our comprehension of the pioneer human if proved correct. In 60 uncomplicated pregnancies, we profiled chorionic villi (CV) and amniotic fluids (AF) relation to maternal saliva, rectum, vagina soluble cytokines cascade vagina, CV AF. series, 12/37 (32%) AF 10/23 (44%) tested positive for bacterial DNA. harbored DNA Streptococcus Lactobacillus, overlapping that matched oral vaginal niches, which showed a dysbiotic...