A5032780441- Tuberculosis Research and Epidemiology
- MicroRNA in disease regulation
- Mycobacterium research and diagnosis
- Liver physiology and pathology
- Echinoderm biology and ecology
- vaccines and immunoinformatics approaches
- Hepatocellular Carcinoma Treatment and Prognosis
- Neurological Disease Mechanisms and Treatments
- Advanced biosensing and bioanalysis techniques
- Reproductive System and Pregnancy
- Liver Disease Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Endometriosis Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- Bioactive Compounds and Antitumor Agents
- Fibroblast Growth Factor Research
- Marine Sponges and Natural Products
- Pancreatic and Hepatic Oncology Research
- Extracellular vesicles in disease
- Public Health and Nutrition
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- Inflammatory Biomarkers in Disease Prognosis
- Diverse Scientific Research Studies
- Computational Drug Discovery Methods
Hasanuddin University
2017-2025
Fondazione Italiana Fegato
2017-2018
Background Endometriosis, a chronic gynecological disorder characterized by the ectopic growth of endometrial tissue, involves complex inflammatory and angiogenic mechanisms. MicroRNAs (miRNAs), particularly Let-7a-1 Let-7f-1, have been identified as key regulators these pathways, influencing progression symptoms disease. Objectives This review aims to explore roles miRNA Let-7f-1 in regulation pathways endometriosis, highlighting their potential biomarkers therapeutic targets. Materials...
Colorectal cancer (CRC) is one of the most frequent malignancies. Insufficient comprehensive screening by health authorities raises colorectal risk in developing countries. While colonoscopy gold standard for CRC diagnosis, it has limitations. Faecal immunochemical test (FIT) and guaiac faecal occult blood (gFOBT) are famous tests. FIT more sensitive specific than gFOBT. However, both gFOBT have limited accuracy diagnosing advanced adenoma proximal colon cancer. Matrix-metalloproteinase-9...
Tuberculosis (TB) remains a significant public health challenge worldwide. Currently, Bacillus Calmette-Guerin (BCG) is the only vaccine available for TB prophylaxis. However, efficacy of BCG against adult pulmonary considered inconsistent. This condition encourages researchers to look more effective options, such as subunit vaccines. requires development protect active in productive and ages. There an urgent need vaccines, Calmette-Guérin currently has inconsistent partially adults....
Chronic inflammatory response is one of major contributors in the development hepatocellular carcinoma (HCC). Inflammatory molecules, such as cytokines and growth factors circulation, can be useful diagnosis prognosis patients. The stem cell factor beta (SCGFβ), a newly found protein, secreted sulfated glycoprotein it functions for primitive hematopoietic progenitor cells. level SCGFβ had been reported to elevated several cancer types. However, there very few or even no information on this...
Diagnosis and management of latent tuberculosis (TB) infections are one the challenges eradicating pulmonary TB. A critical aspect controlling TB spread is early diagnosis. One biological marker type under evaluation microRNAs (miRNAs). Mycobacterium infection causes epigenetic changes. The upregulation miRNA-29a-3p suppresses immune response by post-transcriptionally inhibiting interferon (INF)-γ expression in T cells, increasing susceptibility to This study aimed assess as a biomarker...
The efficacy of the BCG vaccine, a widely recognized tuberculosis has shown varying degrees effectiveness, ranging from 0% to 80%. Sirohydrochlorin cobaltochelatase (CbiX), found in Mycobacterium tuberculosis, plays crucial role bacteria metabolism, making it promising target for future vaccine and drug development. Although several studies had been published regarding its M. vitamin B-12 potentials CbiX protein as candidate not discussed nor explored. This study focuses on cloning...
<ns3:p>Background When the brain is deprived of oxygen and nutrients due to stenosis or arterial rupture, neurons in affected area suffer irreversible damage cellular death. MicroRNA has been shown regulate target genes implicated hypertension, atherosclerosis, diabetes mellitus, all which influence risk ischemic stroke through inflammation, oxidative stress, cell proliferation, apoptosis. The study aims determine changes miRNA expression, namely miRNA-21, between acute patients controls...
Eradicating tuberculosis (TB) globally is increasingly challenging with the growing number of drug-resistant Mycobacterium (M. tuberculosis) strains. The development more potent TB vaccines critical to complement overall control strategies and overcome challenge drug resistance. In this study, recombinant plasmid pGEM-T Easy- Rv2873 + Rv3875 has been generated by inserting gene, which encodes ESAT6 protein, into vector at BamHI/HindIII cloning site. Following transformation E. coli JM109,...
Aims: Glutamate cysteine ligase (GCL) enzyme is involved in the synthesis of glutathione, which functions as an antioxidant.Polymorphisms sequence amino acids making up gene GCLC will cause differences expression and activity.Gene that influenced by oxidative stress can be used to measure markers such F2-isoprostanes.This study aims examine association between polymorphism with glutathione plasma level F2-isoprostanes contacts person infectious tuberculosis (TB).Methodology results: Samples...
ABSTRACT Introduction Fas/CD95 is a member of the death receptor superfamily that can induce apoptosis and it functions as key component extrinsic pathway. This study reports on relevant function Fas regulate transcription factors p53, MYC, NF-κ B pro-apoptotic gene PUMA, are important in intrinsic pathway hepatocellular carcinoma (HCC). Material methods For vivo study, genes Fas, FasL from 111 samples (39 HCC, 30 peri-HCC, 31 cirrhosis, 11 normal) patients undergoing liver resection without...