Colorectal cancer (CRC) is one of the most frequent malignancies. Insufficient comprehensive screening by health authorities raises colorectal risk in developing countries. While colonoscopy gold standard for CRC diagnosis, it has limitations. Faecal immunochemical test (FIT) and guaiac faecal occult blood (gFOBT) are famous tests. FIT more sensitive specific than gFOBT. However, both gFOBT have limited accuracy diagnosing advanced adenoma proximal colon cancer. Matrix-metalloproteinase-9...

Background and objectives. Radiological examinations help clinicians establish the diagnosis of acute appendicitis, thereby reducing number diagnostic errors. However, many emergency departments have limited radiological facilities. The Labeda score is an appendicitis scoring system that might be a good alternative. This study aims to determine correlation between severity level appendicitis. Materials methods. preliminary cross-sectional was conducted using clinical findings, preoperative...

The increase of superoxide dismutase (SOD) level in colorectal cancer (CRC) patients based on the examination staging and grade differentiation still evidently represents a clinical problem. SOD raises at certain reduce differentiation. For that reason, this study aimed to assess association between variables analyzed study.This was observational using cross-sectional research design measure as well CRC incidence. conducted our institution from January until March 2018.Statistical analyses...

Tumors most often develop due to inflammatory factors, including cells that produce cytokines and cytotoxic mediators can stimulate malignant transformation. Knowing interleukin-6 (IL-6) C-reactive protein (CRP) factor into the development of colorectal cancer (CRC), we aimed assess IL-6 CRP's relationship with stage differentiation CRC.In a sample 46 patients CRC, as confirmed by histopathological examination, plasma levels CRP were measured from peripheral venous blood samples before...

The 5-year overall survival (OS) rate for colorectal cancer (CRC) has been reported as 39%, and the recurrence-free (RFS) 14%. Various prognostic factors have associated with differences in rates among CRC patients. This study investigated difference between several OS RFS of patients at Dr. Wahidin Sudirohusodo General Hospital Makassar Indonesia.The group comprised all treated Division Digestive Surgery from 2014 to 2016. Prognostic factor data were collected medical records 293 analyzed...

An inguinal hernia is a protrusion of abdominal-cavity contents through the canal. Protection against an depends on integrity fascial tissue, which maintained by collagen. Collagen structural protein consisting amino acids, most common glycine. This study aimed to determine relationship between glycine and appearance lateral hernias. To this end, researchers examined profile collagen levels in tissue sheath rectus femoris patients with (indirect hernia).The used cross-sectional design...

Stomach cancer is the fifth most common malignancy. In 2012, 952,000 cancers were diagnosed worldwide, which led to 723,000 deaths. Elderly men are frequently observed category of gastric patients, mostly affecting antrum. The objective this study was analyze association age with sex, tumor sites, types surgical intervention, and anatomical pathologies in cases cancer. This cross-sectional descriptive analyzed associations between age, among total incidences during medical treatments from...

Introduction: According to the WHO’s GLOBOCAN database, ~1,931,590 new colorectal cancer (CRC) cases and 915,607 CRC-related deaths occurred in 2020. The incidence of CRC Indonesia is 8.6%, making it fourth most common cancer. With CRC, matrix metalloproteinase-9 (MMP-9) has a role tumour development progression, such that patients with higher MMP-9 expression had poorer survival. This study aimed analyze relationship between clinicopathology patients. Methods: was an analytic observational...

Currently, the prevalence of colorectal cancer (CRC) ranks among top four diseases in world. Indonesia third CRC, with poor survival rates. The high CRC requires early diagnosis and intervention. This is expected to improve rate patients CRC. aim this study was compare based on age pathological categories. an observational, analytic a cross-sectional approach consisting 470 diagnosed our institution. Data obtained from medical records, univariate, bivariate, multivariate data analyses...

Introduction: In pancreatic cancer, the carcinogenesis can not be separated from genetics mutations. The portraits of genes alterations majorily including oncogenes (KRAS, HER2, PD-L1) and tumor supressor (P53, CDKN2A, SMAD4). Besides being notorious a screening marker, genetic mutations were related to prognosis cancer. aim this study is determine portrait in predicting overall survival Methods: network meta analysis (NMA) was registered PROSPERO (CRD42023397976) conducted accordance with...

A hernia is a protrusion of an organ or tissue through abnormal anatomical channel opening. Epidemiological data indicated increased prevalence inguinal hernias in patients with connective diseases. The biomechanical strength highly dependent on the constituent matrix, including collagen. Fibroblasts produce and secrete procollagen containing high concentrations proline lysine. Collagen integrity plays essential role preventing formation abdominal wall. To investigate relationship between...

Introduction: Tumor markers combination (CEA, CA19-9, and CA125) can increase sensitivity due to interactions between several epitopes tumor cells, especially in colorectal cancer (CRC) diagnosis. Therefore, this study aimed assess the relationship triple CA 19-9, 125) CRC metastases. Materials Methods: The research samples were patients at Dr. Wahidin Sudirohusodo Hospital, Makassar from November 2019 April 2020. histopathology data collected through endoscopic or anal biopsy, CEA, 125,...

BACKGROUND: Colorectal cancer (CRC) is more common in developed countries. However, with globalization and lifestyle changes, CRC will become developing countries, an estimated 2.5 million new cases worldwide by 2035. A complete blood count test one of the most routine tests performed clinical practice. In recent years, red cell distribution width (RDW) has been used to assess several non-hematological diseases, including cancer. high RDW may indicate a systemic inflammatory state types...

Introduction and importance: Occurring in only 1% of cases anorectal malignancy, malignant melanoma generally appears the fifth sixth decades life, with complaints bleeding or pain. The prognosis is poor. Although currently lacks a recommended treatment, surgery alone remains primary modality role adjuvant therapy minimal, survival rate improves early diagnosis. Presentation case : Here, we report two rare rectum treated abdominoperineal resection local excision. first 60-year-old man...

Colorectal cancer (CRC) staging is essential for effective treatment planning and prognosis. While platelet indices have shown promise in indicating CRC aggressiveness, a index-based predictor has not been established Indonesia. This study aimed to explore the relationship between stage develop predictive model application.

Background: Authors hypothesized the qSOFA score would be useful in sepsis patients caused by gastric perforation. The present study investigated relationship of value to outcome with perforation Samarinda.Methods: This research was analytical, descriptive method using cross-sectional design 70 patients. Data analysis obtained see between age, gender, vital sign and survival patients.Results: Mean systolic blood pressure significantly higher subjects who lived than those died, i.e. 105.5 vs...

Most cases of Hirschsprung disease (HD) are known in newborns or infants. Nevertheless, some with mild symptoms not identified until acute presentations, such as bowel obstruction present adolescence adulthood. We reported a 25-year-old male history chronic constipation from childhood presenting due to HD. As an emergency operation, the Hartmann procedure was performed overcome obstruction. The histological result showed aganglionic segment, confirming plan definitive Duhamel endorectal...

The most prevalent malignancy of the biliary system and fifth common cancer gastrointestinal tract is gallbladder cancer. This extremely aggressive with a 19 % 5-year survival rate. Herein, we report case an ambiguous symptom upper abdominal pain.A 51-year-old woman presented pain persisting for 3 months. On examination, lump on right abdomen measuring 7 × 5 cm was found. Ultrasound showed mass 8 cm, magnetic resonance imaging infiltrating suggestive segment VI liver malignancy. patient...

BACKGROUND: Fistulas are abnormal connections between two epithelial surfaces, such as the anal canal epithelium and perianal skin epidermis. While fistula cases at Dr. Wahidin Sudirohusodo Hospital Makassar considered rare, compared to other diseases, complications can aggravate if not treated immediately. Therefore, this study aimed describe risk factors affecting incidence in detail.METHODS: This cross-sectional used a descriptive observational design. It examined medical records...

BACKGROUND: The 5-year survival rate for colorectal cancer (CRC) in Italy is 47%. Variations patient rates have been linked to different prognostic variables. This study examined the relationship between several variables and CRC at Dr. Wahidin Sudirohusodo General Hospital Makassar (RSWS) Makassar, Indonesia.METHODS: included all patients who underwent gastrointestinal surgery from 2012 2016. Data on factors were collected medical records 513 patients. analyzed using Kaplan-Meier method...

BACKGROUND: Pancreatic cancer is the seventh leading cause of death worldwide. The diagnosis pancreatic tumors remains difficult since resectability challenging to reveal by computed tomography, and unidentified metastases are possible, usually confirmed only on operating table. D-dimer has been reported be a marker hypercoagulability, its appearance in various significantly associated with metastatic stage. Therefore, this study aimed examine association between level tumors.METHODS: We...

BACKGROUND: Implementation of enhanced recovery after surgery (ERAS) protocols has been shown to reduce the length stay (LOS) and complications in colorectal surgery. However, this benefit is closely related protocol compliance, which a significant implementation challenge. This study aimed compare effectiveness implementing an ERAS with conventional terms LOS complications.METHODS: was retrospective conducted at Dr. Wahidin Sudirohusodo Hospital. We collected data from medical records...

BACKGROUND: Many patients suffering from colorectal cancer (CRC) are asymptomatic during the early development of disease (since has a silent progression); however, benign polyps and inflammation colon can cause chronic pain hematochezia affect defecation patterns. These symptoms make it difficult to correctly diagnose problem as CRC. Tenascin C (TNC) is one potential serum biomarkers for CRC cases. In vitro studies have shown that TNC expression influence cell behavior in several ways. The...

Introduction: BRAF mutations (v-RAF murine sarcoma homogeneous viral oncogene B1) has been associated with aggressive phenotypes and are the main prognostic biomarkers for poor outcomes, especially in late-stage colorectal cancer (CRC). Faecal DNA testing become a valid reliable non-invasive procedure detection of CRC. This study aims to determine relationship V600E mutation CRC patients' faecal location, histopathology, degree tumour differentiation. Material Methods: used data from 43...

Background: The conversion from laparoscopic cholecystectomy to open often results pericholecystic Adhesion. Pericholecystic Adhesion is a result of cholecystitis in the case cholelithiasis. C-Reactive Protein (CRP) and Erythrocyte Sedimentation Rate (ESR) can be increased used as predictive factor for degree difficulty cholecystectomy. This study aims determine relationship between CRP ESR with gall bladder adhesion on at Abdul Wahab Sjahranie Hospital, Samarinda.Method: A cross-sectional...