A5051331291- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- Long-Term Effects of COVID-19
- Asthma and respiratory diseases
- Vaccine Coverage and Hesitancy
- Air Quality and Health Impacts
- Occupational exposure and asthma
- COVID-19 and Mental Health
- Allergic Rhinitis and Sensitization
- Infection Control and Ventilation
- vaccines and immunoinformatics approaches
- Contact Dermatitis and Allergies
- COVID-19 Pandemic Impacts
- COVID-19 and healthcare impacts
- Data-Driven Disease Surveillance
- Health, psychology, and well-being
- Stoma care and complications
- Basque language and culture studies
- Respiratory and Cough-Related Research
- Public Health Policies and Education
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Smoking Behavior and Cessation
- School Health and Nursing Education
University of Verona
2020-2024
Azienda Ospedaliera Universitaria Integrata Verona
2024
Institute of Occupational Medicine
2020
Introduction: The impact of long-COVID-19 syndrome is rather variable, since it influenced by several residual confounders. This study aimed to investigate the prevalence long COVID-19 in healthcare workers (HCWs) from four university hospitals north-eastern Italy: Trieste, Padua, Verona, and Modena-Reggio Emilia. Methods: During period June 2022-August 2022, HCWs were surveyed for past infections, medical history, any acute as well post-COVID-19 symptoms. was estimated at 30-60 days or 61+...
Anti SARS-CoV-2 vaccination initially showed high effectiveness in preventing COVID-19. However, after the surge of variants concern, dropped. Several studies investigated if this was related to decrease humoral response over time; however, issue is still unclear. The aim study understand whether anti-S IgG levels can be used predict breakthrough infection risk and define timing for further booster doses administration.
The SARS-CoV-2 vaccination campaign began on 27 December 2020 in Europe, primarily involving health workers. This study aimed to assess the effectiveness, as assessed by reductions incidence, symptom severity, and further infection spreading.A retrospective cohort was conducted 9811 workers operating at Verona University Hospital, Italy, from 3 May 2021. All were offered with Comirnaty (BNT162b2, BioNTech/Pfizer, Mainz, Germany/New York, United States), a surveillance program implemented...
The research aimed to investigate the incidence of SARS-CoV-2 breakthrough infections and their determinants in a large European cohort more than 60,000 health workers.A multicentric retrospective study, involving 12 centers, was carried out within ORCHESTRA project, collecting data up 18 November 2021 on fully vaccinated workers. cumulative investigated with its association occupational social-demographic characteristics (age, sex, job title, previous infection, antibody titer levels, time...
Background The duration of immune response to COVID-19 vaccination is major interest. Our aim was analyze the determinants anti-SARS-CoV-2 IgG titer at 6 months after 2-dose in an international cohort vaccinated healthcare workers (HCWs). Methods We analyzed data on levels Spike antibodies and sociodemographic clinical characteristics 6,327 HCWs from 8 centers Germany, Italy, Romania Slovakia. Time between 1 st dose serology ranged 150-210 days. Serological were log-transformed account for...
SARS-CoV-2 breakthrough infections (BI) after vaccine booster dose are a relevant public health issue.Multicentric longitudinal cohort study within the ORCHESTRA project, involving 63,516 workers (HW) from 14 European settings. The investigated cumulative incidence of BI and its correlation with age, sex, job title, previous infection, time since third dose.13,093 (20.6%) were observed. was higher in women HW aged < 50 years, but nearly halved 60 years. Nurses experienced highest incidence,...
Variant-adapted vaccines are recommended in vulnerable populations to address the waning immunity and emergence of immune-escaping SARS-CoV-2 variants, yet data about immune responses such people living with HIV (PLWH) limited. We therefore aimed assess long-term an original–BA.4/5 mRNA booster this population. In prospective longitudinal study, PLWH receiving either bivalent or original monovalent HIV-negative healthcare workers (HCWs) a were enrolled sampled before (T0), 1 month (T1), 4–9...
Introduction: Characterizing immunological response following COVID-19 vaccination is an important public health issue. The objectives of the present analysis were to investigate proportion, level and determinants humoral from 21 days three months after first dose in vaccinated healthcare workers (HCWs). Methods: We abstracted data on anti-SARS-CoV-2 Spike antibodies (IgG) sociodemographic characteristics 17,257 HCWs hospitals authorities centers Northern Italy who underwent (average 70.6...
Understanding antibody persistence concerning multimorbidity is crucial for vaccination policies. Our goal to assess the link between and serological response SARS-CoV-2 nine months post-first vaccine. We analyzed Healthcare Workers (HCWs) from three cohorts Italy, one each Germany, Romania, Slovakia, Spain. Seven groups of chronic diseases were analyzed. included 2941 HCWs (78.5% female, 73.4% ≥ 40 years old). Multimorbidity was present in 6.9% HCWs. The prevalence condition ranged 1.9%...
Background: The effectiveness of the immunity provided by SARS-CoV-2 vaccines is an important public health issue. We analyzed determinants 12-month serology in a multicenter European cohort vaccinated healthcare workers (HCW). Methods: sociodemographic characteristics and levels anti-SARS-CoV-2 spike antibodies (IgG) 16,101 HCW from eleven centers Germany, Italy, Romania, Slovakia Spain. Considering skewness distribution, serological were transformed using log or cubic standardization...
People living with HIV (PLWH) despite having an appreciable depletion of CD4
Abstract Background Gastroesophageal reflux disease (GERD) has been reported to be significantly associated with chronic rhinosinusitis, but the strength of association is still debated. Aims To evaluate between gastritis/GERD and non-allergic rhinitis (NAR)/allergic (AR)/sinusitis. Methods We investigated 2887 subjects aged 20–84 years, who underwent a clinical visit in seven Italian centres (Ancona, Palermo, Pavia, Terni, Sassari, Torino, Verona) within study on Gene Environment...
Objectives Wheat flour exposure in bakers can elicit respiratory and skin symptoms. Scarce data are available on the prevalence of such conditions bakers. We investigated work-related rhinitis, asthma-like symptoms dermatitis according to job task type allergens involved. Methods Of 229 traditional bakeries Verona area who were invited participate a cross-sectional survey, 211 (92%) accepted; 727 employees these answered modified version questionnaire tasks; allergen within bakery; nasal,...
Wheat allergens are responsible for symptoms in 60-70% of bakers with work-related allergy, and knowledge, at the molecular level, this disorder is progressively accumulating. The aim present study to investigate panel wheat IgE positivity allergic Italian bakers, evaluating a possible contribution novel included water/salt soluble fraction. water/salt-soluble flour proteins from cultivar Bolero were separated by using 1-DE 2-DE gel electrophoresis. IgE-binding detected pooled sera 26...
Background: The persistence of antibody levels after COVID-19 vaccination has public health relevance. We analyzed the determinants quantitative serology at 9 months in a multicenter cohort. Methods: data on anti-SARS-CoV-2 spike from first dose vaccinated HCW eight centers Italy, Germany, Spain, Romania and Slovakia. Serological were log-transformed to account for skewness distribution normalized by dividing them center-specific standard errors. fitted multivariate regression models...
Background: Health care workers (HCWs) were on the frontline of current pandemic. We aimed at identifying determinants SARS-CoV-2 infection and effectiveness personal protection equipment (PPE) worn by HCWs before vaccination. Methods: abstracted data based positive PCR results sociodemographic characteristics 38,793 from public hospitals health authorities 10 European centers. fitted cohort-specific multivariate logistic regression models to identify combined using random-effects...
Background: To report the baseline phase of SIEROEPID study on SARS-CoV-2 infection seroprevalence among health workers at University Hospital Verona, Italy, between spring and fall 2020; to compare performances several laboratory tests for antibody detection. Methods: 5299 voluntary were enrolled from 28 April 2020 July assess immunological response throughout IgM, IgG IgA serum levels titration by four tests. Association titre with demographic variables, swab performance (sensitivity,...
We investigated changes in serologic measurements after COVID-19 vaccination 19,422 subjects. An individual-level analysis was performed on standardized measurements. Age, infection, vaccine doses, time between doses and serologies, type were associated with levels within 13 months. Persistence of immunization is key for prevention. the difference two anti-COVID-19 S1 antibodies an vaccinated healthcare workers (HCW) from Italy, Spain, Romania, Slovakia, tested months first dose. Differences...
Excessive salt consumption is one of the leading causes high blood pressure. Worldwide intake largely exceeds WHO recommended amount. This study aimed to evaluate prevalence consumers and effectiveness a short-term workplace educational intervention among health workers. An online survey, assessing daily through MINISAL-SIIA questionnaire, was sent 4911 workers employed by University Hospital Verona, Italy. Health who had (total score ≥ 10) or moderate = 8/9) associated with obesity arterial...
Co-exposures and polysensitization to several pollen species are very common in real life practice. However, little information exists on allergic symptoms airway inflammation related natural exposure large general population samples.To assess the combined effect of sensitization and/or one or more Fraction exhaled Nitric Oxide (FeNO) levels.Within Gene Environment Interactions Respiratory Diseases (GEIRD) multicase-control study, 1070 adults from Verona, Italy, underwent a clinical...
Abstract People living with HIV (PLWH) despite having appreciable depletion of CD4 + T-cell show a good SARS- CoV-2 vaccination response. The underlying mechanism(s) are currently not understood. We studied serological and polyfunctional responses in PLWH receiving anti-retroviral therapy stratified on counts as PLWH-high (CD4 ≥500 cells/μL) PLWH-low (<500 cells/μL). Responses were assessed longitudinally before the first (T0), 1-month after dose (T1), 3- months (T2), 6-months (T3) second...
occupational exposure to vapours, gases, dusts and fumes (VGDF) plays an important role in the development exacerbation of respiratory diseases. The aim this study is evaluate possible association airborne pollutants chronic