A5002853488- Lipoproteins and Cardiovascular Health
- Clinical Laboratory Practices and Quality Control
- Fatty Acid Research and Health
- Iron Metabolism and Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- Antioxidant Activity and Oxidative Stress
- Ion channel regulation and function
- Liver Disease Diagnosis and Treatment
- Muscle metabolism and nutrition
- Hepatitis C virus research
- Dialysis and Renal Disease Management
- Air Quality and Health Impacts
- Hormonal Regulation and Hypertension
- Ion Transport and Channel Regulation
- Cholesterol and Lipid Metabolism
- Trace Elements in Health
- Autoimmune Neurological Disorders and Treatments
- SARS-CoV-2 and COVID-19 Research
- Erythrocyte Function and Pathophysiology
- Lipid metabolism and disorders
- Diet, Metabolism, and Disease
- Retinoids in leukemia and cellular processes
- Peripheral Neuropathies and Disorders
- Smoking Behavior and Cessation
University of Verona
2007-2022
British American Tobacco (United Kingdom)
2010
Western University
2007
University of Maiduguri
1999-2006
Azienda Ospedaliera Universitaria Integrata Verona
2004-2005
University of Padua
1988-1996
University of Naples Federico II
1992-1995
Medica (Italy)
1987
Institute of Molecular Biology and Pathology
1987
The metabolic syndrome, clinically defined by the Adult Treatment Panel III (ATPIII) (1), affects ∼25% of western adults (2). syndrome is closely linked to insulin resistance and implies an increased cardiovascular risk (3,4). Accumulating evidence suggests a link between body iron excess metabolism (5). Studies have shown association serum ferritin one or more feature (6–11). Moreover, characterized hepatic overload (HIO) associated with features (insulin resistance–associated HIO...
Background. Iron deficiency (ID) is the main cause of hyporesponsiveness to erythropoietin in haemodialysis patients and its detection value since it easily corrected by intravenous iron. Markers iron supply erythron, including erythrocyte zinc protoporphyrin (Er‐ZPP), percentage hypochromic erythrocytes (Hypo), reticulocyte haemoglobin content (CHr) soluble transferrin receptor (sTfR), may be more accurate predictors ID than ferritin (Fer) saturation (TSat), but relative diagnostic power...
Article Assessment of immune response to SARS-CoV-2 with fully automated MAGLUMI 2019-nCoV IgG and IgM chemiluminescence immunoassays was published on July 1, 2020 in the journal Clinical Chemistry Laboratory Medicine (CCLM) (volume 58, issue 7).
Current evidence suggests that no single serum biomarker displays satisfactory diagnostic performance in patients with endometrial carcinoma (EC), the most frequent gynecological cancer developed countries. However, aberrant tissue microRNA (miRNA) expression has been recently described EC. Therefore, this study aimed to investigate differential of 4 miRNAs and their association CA125 (cancer antigen 125) HE4 (human epididymis protein 4) EC a control population.Forty-six consecutive women 28...
Total quality in coagulation testing is a necessary requisite to achieve clinically reliable results. Evidence was provided that poor standardization the extra-analytical phases of process has greatest influence on test results, though little information available so far prevalence and type pre-analytical variability testing.The present study designed describe all problems inpatients routine stat samples recorded our laboratory over 2-year period clustered according their source (hospital...
Abstract Background: Despite the importance of manual pipetting fluids such as water, solutions, buffers, reagents, or biological samples in daily laboratory practice, intra- and inter-individual imprecision this activity has not been recently described scientific publications. Methods: Twenty operators were randomly enrolled for study. Imprecision was estimated by asking each professional to dispense 1 mL, 100 μL 10 distilled water consecutive times with three certified pipettes into a...
Several polymorphisms in the apolipoprotein C-III (apoC-III) gene have been associated with hypertriglyceridemia, but link coronary artery disease risk is still controversial. In particular, apoC-III promoter sequence variants insulin responsive element (IRE), constitutively resistant to downregulation by insulin, never investigated this connection. We studied a total of 800 patients, 549 whom had angiographically documented atherosclerosis, whereas 251 normal arteriograms. measured plasma...
1. In this study we sought to test the possibility that an olive-oil-rich diet might influence membrane lipid composition and cation transport mechanisms in erythrocytes. 2. To end, 11 normotensive normolipidaemic healthy volunteers were given a standard relatively low fat (28% of total energy) for 3 weeks, followed by high (38% energy), olive-oil (100 g/day)-enriched subsequent metabolic ward. The two diets contained same amount cholesterol (400 mg), polyunsaturated fatty acid/saturated...
Anomalies in the erythrocyte transport of anions and cations have been described idiopathic calcium oxalate nephrolithiasis seem to play a pathogenetic role this disease. In consideration hypothesis that complex array ion flux cell abnormalities is an epiphenomenon anomaly composition membranes, study investigated cell-membrane lipid composition. renal stone formers, which were present, healthy control subjects, plasma membrane composition, exchange, Na/K/2Cl cotransport activity evaluated....
Abstract Despite the well-documented role of cigarette smoke in development chronic obstructive pulmonary disease (COPD), lung cancer and cardiovascular disease, biomarkers for screening or monitoring progression outcome remain elusive, particularly COPD cancer. Inflammatory cells mediators are likely to be involved processes, but their importance is still poorly understood. The purpose this study was investigate early changes immunological markers associated with smoking healthy monozygotic...
Abstract Background: Apolipoprotein C-III (apo C-III) is a marker of cardiovascular disease risk associated with triglyceride (TG)-rich lipoproteins. The T−455C polymorphism in the insulin-responsive element APOC3 gene influences TG and apo concentrations. Long-chain n-3 polyunsaturated fatty acids (PUFAs) contained fish have well-known C-III-lowering properties. Methods: We investigated possibility an interactive effect between variant erythrocyte PUFAs, suitable markers dietary intake...
To investigate tools for evaluation of smoking-associated disease initiation and progression, we examined basic clinical parameters biomarkers cardiovascular risk, in a group healthy volunteers with an average 10-year smoking history. A small cross-sectional study never-smokers, moderate smokers was performed. Caucasians were recruited to match pre-defined cigarette tar yields cigarettes smoked per day. For haematological parameters, significant differences between never-smokers all female...
The verification/validation of laboratory test results is one the most critical aspects total testing process, which may produce conflicts between competencies and duties at point professional crossroads. This process has centered for decades on human component, with positive effects as well potential adverse consequences (postanalytical errors). Manual validation data a time-consuming activity, inherently subjective arbitrary, requires constant presence postgraduate physicians or biologists...
Abstract: Medical science has undergone a substantial revolution in recent years, wherein the traditional approach to diagnosing and treating many human diseases gradually evolved from generalized conception of health disease an individualized entailing decisions interventions tailored single patient according individual responses or risk disease. This axiom concept practice, been translated into notion "personalized" "precision" medicine. Although precision (personalized) medicine will be...
In C6 glioma cells exposed to chemical hypoxia a massive release of lactate dehydrogenase (LDH) occurred at 3 and 6 h, coupled with an increased number propidium‐iodide positive dead cells. Extracellular Na + removal, which activates the ‐Ca 2+ exchanger as efflux pathway prevents entrance, significantly reduced LDH propidium iodide During hypoxia, in presence extracellular ions, progressive increase [Ca ] i occurred; absence ions was enhanced greater extent. The blockade by amiloride...
Background: Serum paraoxonase (PON1) exerts antiatherogenic effects. Novel PON1 enzymatic tests have been recently developed: 5-thiobutyl butyrolactone (TBBL) estimates lactonase activity, whereas 7-O-diethylphosphoryl-3-cyano-4-methyl-7-hydroxycoumarin (DEPCyMC) is considered a surrogate marker of concentration. The TBBL to DEPCyMC ratio provides the normalized activity (NLA), which may reflect degree catalytic stimulation. aim this study was evaluate for first time TBBLase and DEPCyMCase...