A5069912344- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- RNA modifications and cancer
- Cannabis and Cannabinoid Research
- Acute Myeloid Leukemia Research
- Cancer-related gene regulation
- Pancreatic function and diabetes
- Retinoids in leukemia and cellular processes
- Kruppel-like factors research
- Oral Health Pathology and Treatment
- Ubiquitin and proteasome pathways
- Photodynamic Therapy Research Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Diet, Metabolism, and Disease
- Heme Oxygenase-1 and Carbon Monoxide
- Protein Degradation and Inhibitors
- Polyamine Metabolism and Applications
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Connexins and lens biology
- Head and Neck Cancer Studies
University of Perugia
2008-2024
General Department of Preventive Medicine
2012
MicroRNAs (miRNAs) are small non-coding RNAs which contribute to the regulation of many physiological and pathological processes. Conventionally, miRNAs perform their activity in cytoplasm where they regulate gene expression by interacting a sequence-specific manner with mature messenger RNAs. Recent studies point presence nucleus. This review summarizes current findings regarding molecular activities nuclear miRNAs. These molecules can at transcriptional level directly binding DNA on...
Non-small cell lung cancer (NSCLC) is the primary cause of cancer-related death worldwide, with a low 5-year survival rate even in fully resected early-stage disease. Novel biomarkers to identify patients at higher risk relapse are needed. We studied prognostic value 84 circulating microRNAs (miRNAs) 182 NSCLC (99 adenocarcinoma (ADC), 83 squamous carcinoma (SCC)) from whom peripheral blood samples were collected pre-surgery. miRNA expression was analyzed relation disease-free (DFS) and...
Abstract Objectives The aim of this work is to investigate the biological effects IQOS smoking on human gingival fibroblasts and keratinocytes analysing cell viability, morphology, migration, apoptosis cycle. Background Electronic cigarettes tobacco heating systems have been marketed reduce damages caused by combustion. Methods Human viability was determined a colorimetric assay measuring mitochondrial dehydrogenase activity (MTT assay); after an in vitro exposure 24 h, morphology analysed...
Retinoic acid controls hematopoietic differentiation through the transcription factor activity of its receptors. They act on specific target genes by recruiting protein complexes that deacetylate or acetylate histones and modify chromatin status. The regulation this process is affected histone methyltransferases, which can inhibit activate depending their amino target. We show here retinoic treatment cells induces expression BTG2. Overexpression increases RARalpha transcriptional response to...
Advances in the understanding of epigenetic events underlying regulation developmental genes expression and cell lineage commitment are revealing novel regulatory networks. These also involve distinct components pathways, including chromatin histone modification, DNA methylation, repression by polycomb complexes microRNAs. Changes structure, methylation status microRNA levels represent flexible, reversible heritable mechanisms for maintenance stem states fate decisions. We recently provided...
Epigenetic alterations, including aberrant DNA methylation, contribute to tumor development and progression. Silencing of suppressor genes may be ascribed promoter hypermethylation, a reversible phenomenon intensely investigated as potential therapeutic target. Previously, we demonstrated that eicosapentaenoic acid (EPA) exhibits demethylating action promotes the re-expression gene CCAAT/enhancer-binding protein δ (C/EBPδ). The C/EBPβ/C/EBPδ heterodimer formed appears essential for monocyte...
MicroRNAs are small non-coding RNAs, which contribute to the regulation of many physiolog-ical and pathological processes. Conventionally, miRNAs perform their activity in cyto-plasm, where they regulate gene expression by interacting a sequence-specific manner with mature messenger RNAs. Recent studies point presence nucleus. This review summarizes current findings regarding molecular activities nuclear miRNAs. These molecules can at transcriptional level directly binding DNA on promoter or...
In cancer cells, global genomic hypomethylation is found together with localized hypermethylation of CpG islands within the promoters and regulatory regions silenced tumor suppressor genes. Demethylating agents may reverse hypermethylation, thus promoting gene re-expression. Unfortunately, demethylating strategies are not efficient in solid cells. DNA demethylation mediated by ten-eleven translocation (TET) enzymes. They sequentially convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine...