A5025742350- Neuroblastoma Research and Treatments
- Cancer Treatment and Pharmacology
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Extracellular vesicles in disease
- Lung Cancer Treatments and Mutations
- Melanoma and MAPK Pathways
- MicroRNA in disease regulation
- Lung Cancer Research Studies
- Cutaneous Melanoma Detection and Management
- HER2/EGFR in Cancer Research
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Neonatal Respiratory Health Research
- Cytokine Signaling Pathways and Interactions
- Estrogen and related hormone effects
- RNA Research and Splicing
- Anesthesia and Pain Management
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Circular RNAs in diseases
- Urological Disorders and Treatments
- RNA modifications and cancer
- CAR-T cell therapy research
- Horticultural and Viticultural Research
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2018-2025
University of Parma
2019-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2004-2024
University of Trento
2013-2018
Genomics (United Kingdom)
2014
Intensive Care Foundation
2014
University of Bologna
2004-2012
Policlinico S.Orsola-Malpighi
2005-2012
Università Cattolica del Sacro Cuore
2011
Università di Camerino
2008
Post-transcriptional regulation (PTR) of gene expression is now recognized as a major determinant cell phenotypes. The recent availability methods to map protein-RNA interactions in entire transcriptomes such RIP, CLIP and their variants, together with global polysomal ribosome profiling techniques, are driving the exponential accumulation vast amounts data on mRNA contacts cells, corresponding predictions PTR events. However, this exceptional quantity information cannot be exploited at its...
Non-small cell lung cancer (NSCLC) is the primary cause of cancer-related death worldwide, with a low 5-year survival rate even in fully resected early-stage disease. Novel biomarkers to identify patients at higher risk relapse are needed. We studied prognostic value 84 circulating microRNAs (miRNAs) 182 NSCLC (99 adenocarcinoma (ADC), 83 squamous carcinoma (SCC)) from whom peripheral blood samples were collected pre-surgery. miRNA expression was analyzed relation disease-free (DFS) and...
The steroid receptor coactivator 3 gene (SRC-3) (AIB1/ACTR/pCIP/RAC3/TRAM1) is a p160 family transcription and known oncogene. Despite its importance, the functional regulation of SRC-3 remains poorly understood within cellular context. Using novel combination live-cell, high-throughput, fluorescent microscopy, we report to be nucleocytoplasmic shuttling protein whose intracellular mobility, solubility, localization are regulated by phosphorylation estrogen alpha (ERalpha) interactions. We...
The fungus Fusarium verticillioides is commonly associated with maize production in temperate regions of the world, producing ear rot and grain contamination by fumonisins. Genetic resistance best preventive action against fumonisin contamination, although at present no commercial hybrids are completely resistant. Several studies relationship between other species suggest that these fungal interact similar ways host plant. Consequently, plant to one pathogen could be another. aim this study...
We examined the reliability of main prenatal and postnatal prognosis-related indexes that can be used to evaluate congenital diaphragmatic hernia (CDH) outcome.Seventy-seven neonates with CDH were analyzed according factors, divided into findings, clinical values predictive outcome scores applied at birth within first 12-24 h. The data are compared between two groups: survivors non-survivors.During age, major associated anomalies, intrathoracic stomach, diagnosis prior 25 weeks gestational...
Abstract Novel druggable targets have been discovered in neuroblastoma (NB), paving the way for more effective treatments. However, children with high-risk NB still show high mortality rates prompting a search of novel therapeutic options. Here, we aimed at repurposing FDA-approved drugs treatment by performing high-content screening 349 anticancer compounds library. In primary screening, employed three cell lines, grown as three-dimensional (3D) multicellular spheroids, which were treated...
Abstract Background Factors to accurately stratify patients with early-stage non-small cell lung cancer (NSCLC) in different prognostic groups are still needed. This study aims investigate 1) the potential of circulating cell-free (CF) and extracellular vesicles (EVs)-derived microRNA (miRNAs), 2) their added value respect known factors (PFs). Methods The RESTING is a multicentre prospective observational cohort on resected stage IA-IIIA NSCLC. primary end-point was disease-free survival...
The nerve growth factor (NGF) receptor tyrosine-kinase TrkA is a well-known determinant of the melanocytic lineage, through modulation MAPK and AKT cascades. While gene frequently rearranged in cancers, its involvement malignant melanoma (MM) development still unclear.We analyzed dataset primary cutaneous MM (n = 31) by array comparative genomic hybridization (aCGH), to identify amplifications associated with tumor progression. analysis was validated quantitative PCR (qPCR) on an extended...
Analysis of circulating cell-free tumor DNA (cftDNA) has emerged as a specific and sensitive blood-based approach to detect epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) patients. Still, there is some debate on what should be the preferential clinical method for plasma-derived cftDNA analysis. We tested 31 NSCLC patients treated with anti-EGFR tyrosine kinase inhibitors (TKIs), at baseline serially during therapy, by comparing three methodologies...
The mutational status of the epidermal growth factor receptor ( EGFR ) guides stratification non‐small cell lung cancer (NSCLC) patients for treatment with tyrosine kinase inhibitors (TKIs). A liquid biopsy test on cell‐free DNA is recommended as a clinical decision‐supporting tool, although it has limited sensitivity. Here, we comparatively investigated extracellular vesicle (EV)‐RNA an independent source multidimensional and longitudinal profiling in cohort 27 NSCLC patients. We introduced...
Identification of prognostic melanoma-associated copy number alterations (CNAs) is still an area active research. Here, we investigated by high-resolution array comparative genomic hybridization (aCGH) a cohort 31 paraffin-preserved primary malignant melanomas (MMs), whose prognosis was not predictable on the basis conventional histopathological parameters. Although identified variety highly recurrent sites lesions, total CNAs per patient discriminator MM outcome. Furthermore, validation...
Background: Metastatic melanoma remains one of the most aggressive forms cancer, with a survival expectation above six months only in rare cases. Despite advances characterization underlying molecular pathways and development specific targeted treatments, available chemo- immuno-therapy are unable to prolong significantly advanced-stage melanoma. Rai like protein (RaLP) is newly identified Src homology 2 domain containing (Shc) family member selectively expressed during transition metastatic...
Abstract Background and Aims At the rear edge of distribution species, extreme isolation small population size influence genetic diversity differentiation plant populations. This may be particularly true for Arctic-alpine species in mid-latitude mountains, but exactly how peripherality has shaped their reproductive characteristics is poorly investigated. The present study, focused on Salix herbacea, aims at providing new insights into causes behind ongoing demographic dynamics consequences...
Very few data are reported in the literature on association between elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) and prognosis advanced colorectal cancer. Moreover, there is no information available relation to response antiangiogenic treatment. We analyzed EMAST vascular endothelial growth factor-B (VEGF-B) status, together with standard instability (MSI), 141 patients metastatic cancer (mCRC) treated chemotherapy (CT) alone (n = 51) or bevacizumab (B) (CT...