A5059663572- Signaling Pathways in Disease
- Histone Deacetylase Inhibitors Research
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Retinoids in leukemia and cellular processes
- Platelet Disorders and Treatments
- Angiogenesis and VEGF in Cancer
- Immune cells in cancer
- RNA Interference and Gene Delivery
- High Altitude and Hypoxia
- Diabetes and associated disorders
- Macrophage Migration Inhibitory Factor
- Adipose Tissue and Metabolism
- Chemokine receptors and signaling
- Kruppel-like factors research
- HIV Research and Treatment
- Telomeres, Telomerase, and Senescence
- Extracellular vesicles in disease
- Muscle Physiology and Disorders
- Galectins and Cancer Biology
- Phagocytosis and Immune Regulation
- Protein Degradation and Inhibitors
- Apelin-related biomedical research
Istituto Superiore di Sanità
2009-2024
University of Rome Tor Vergata
2015
Metabolism in acute myeloid leukemia (AML) cells is dependent primarily on oxidative phosphorylation. However, order to sustain their high proliferation rate and metabolic demand, leukemic blasts use a number of strategies, including glycolytic metabolism. Understanding whether monocarboxylate transporters MCT1 MCT4, which remove the excess lactate produced by cancer cells, represent new hematological targets, respective inhibitors, AR-C155858 syrosingopine, can be useful therapy, may reveal...
Abstract Background and Aims Intestinal fibrosis is a common complication of inflammatory bowel diseases. Medical treatment intestinal an unmet therapeutic need. CD147 overexpression can induce myofibroblast differentiation associated with extracellular matrix deposition, favouring the development fibrosis. To understand whether may promote fibrosis, we analysed its expression blocked function by using specific inhibitor AC-73 [3-{2-[([1,1’-biphenyl]-4-ylmethyl) amino]-1-hydroxyethyl}...
CXCR4 is a negative prognostic marker in acute myeloid leukemias (AMLs). Therefore, it necessary to develop novel ways inhibit expression leukemia. AMD3100 an inhibitor of currently used mobilize cancer cells. target microRNA (miR)-146a that may represent new tool expression. We then investigated regulation by miR-146a primary AMLs and found inverse correlation between protein levels all AML subtypes. As the lowest were observed M5 AML, we analyzed control normal leukemic monocytic cells...
CD147 is a transmembrane glycoprotein with multiple functions in human healthy tissues and diseases, particular cancer. Overexpression of correlates biological that promote tumor progression confers resistance to chemotherapeutic drugs. In contrast solid tumors, the role has not been extensively studied leukemia. Understanding whether represents new hematologic target its inhibitor AC-73 may be used leukemia therapy reveal an alternative treatment strategy patients acute myeloid (AML). We...
MicroRNA miR-146a and PLZF are reported as major players in the control of hematopoiesis, immune function cancer. is described a repressor, whereas CXCR4 TRAF6 were identified direct targets different cell types. co-receptor CD4 molecule that facilitates HIV-1 entry into T lymphocytes myeloid cells, involved response. Thus, role infection currently being thoroughly investigated. In this study, we found mediates suppression to increases protein levels human primary CD4+ lymphocytes. We show...
Coagulation disorders are described in COVID-19 and long COVID patients. In particular, SARS-CoV-2 infection megakaryocytes, which precursors of platelets involved thrombotic events COVID-19, and, rare cases, vaccinated individuals, requires further investigation, particularly with the emergence new variants. CD147, regulation inflammation required to fight virus infection, can facilitate entry into megakaryocytes. MCT4, a co-binding protein CD147 key player glycolytic metabolism, could also...
High expression of the chemokine receptor 4, CXCR4, associated with a negative prognosis in acute myeloid leukemia, is related to hypoxia. Because CXCR4 under post-transcriptional control microRNA-146a normal and leukemic monocytic cells, we first investigated impact hypoxia on during monocytopoiesis leukemia. We then analyzed effects drug sensitivity CXCR4-expressing cells. found that target hypoxia-inducible factor-1α or -2α relation stage level hypoxia, demonstrated regulation...
Background The transmembrane 9 superfamily protein member 4, TM9SF4, belongs to the TM9SF family of proteins highly conserved through evolution. TM9SF4 homologs, previously identified in many different species, were mainly involved cellular adhesion, innate immunity and phagocytosis. In human, function biological significance are currently under investigation. However, was found overexpressed human metastatic melanoma a small subset acute myeloid leukemia (AMLs) myelodysplastic syndromes,...
The tyrosine kinase Tie-2 and its ligands Angiopoietins (Angs) transduce critical signals for angiogenesis in endothelial cells. This receptor Ang-1 are coexpressed hematopoietic stem cells a subset of megakaryocytes, though possible role angiopoietins megakaryocytic differentiation/proliferation remains to be demonstrated. To investigate effect Ang-1/Ang-2 on proliferation/differentiation we have used both normal CD34+ induced differentiation the UT7 engineered express thrombopoietin (TPOR,...
Hematological malignancies refer to a heterogeneous group of neoplastic conditions lymphoid and hematopoietic tissues classified in leukemias, Hodgkin non-Hodgkin lymphomas multiple myeloma, according their presumed cell origin, genetic abnormalities, clinical features. Metabolic adaptation immune escape, which influence various cellular functions including proliferation survival hematological malignant tumor cells, are major aspects these that lead therapeutic drug resistance. Targeting...
Duchenne Muscular Dystrophy, a genetic disorder that results in gradual breakdown of muscle, is associated to mild severe cognitive impairment about one-third dystrophic patients. The brain dysfunction independent the muscular pathology, occurs early, and most likely due defects assembly Dystrophin-associated Protein Complex (DPC) during embryogenesis. We have recently described interaction DPC component β-dystrobrevin with members complexes regulate chromatin dynamics, suggested may play...