A5071136269- Acute Myeloid Leukemia Research
- Angiogenesis and VEGF in Cancer
- Histone Deacetylase Inhibitors Research
- Hemoglobinopathies and Related Disorders
- Cell death mechanisms and regulation
- Neuroscience and Neuropharmacology Research
- Signaling Pathways in Disease
- Retinoids in leukemia and cellular processes
- MicroRNA in disease regulation
- Erythrocyte Function and Pathophysiology
- Immune Cell Function and Interaction
- Blood properties and coagulation
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Craniofacial Disorders and Treatments
- Neurological disorders and treatments
- Identification and Quantification in Food
- Molecular Biology Techniques and Applications
- Cleft Lip and Palate Research
- Receptor Mechanisms and Signaling
- RNA and protein synthesis mechanisms
- Phagocytosis and Immune Regulation
- Chronic Lymphocytic Leukemia Research
Istituto Superiore di Sanità
2012-2024
University of Rome Tor Vergata
2001-2015
MultiMedica
2010
Fondazione Santa Lucia
2001-2003
Sidney Kimmel Cancer Center
2003
Thomas Jefferson University
2003
Istituti di Ricovero e Cura a Carattere Scientifico
2003
Metabolism in acute myeloid leukemia (AML) cells is dependent primarily on oxidative phosphorylation. However, order to sustain their high proliferation rate and metabolic demand, leukemic blasts use a number of strategies, including glycolytic metabolism. Understanding whether monocarboxylate transporters MCT1 MCT4, which remove the excess lactate produced by cancer cells, represent new hematological targets, respective inhibitors, AR-C155858 syrosingopine, can be useful therapy, may reveal...
Abstract Background and Aims Intestinal fibrosis is a common complication of inflammatory bowel diseases. Medical treatment intestinal an unmet therapeutic need. CD147 overexpression can induce myofibroblast differentiation associated with extracellular matrix deposition, favouring the development fibrosis. To understand whether may promote fibrosis, we analysed its expression blocked function by using specific inhibitor AC-73 [3-{2-[([1,1’-biphenyl]-4-ylmethyl) amino]-1-hydroxyethyl}...
CD147 is a transmembrane glycoprotein with multiple functions in human healthy tissues and diseases, particular cancer. Overexpression of correlates biological that promote tumor progression confers resistance to chemotherapeutic drugs. In contrast solid tumors, the role has not been extensively studied leukemia. Understanding whether represents new hematologic target its inhibitor AC-73 may be used leukemia therapy reveal an alternative treatment strategy patients acute myeloid (AML). We...
BackgroundThe human hemoglobin switch (HbF→HbA) takes place in the peri/post-natal period.In adult life, however, residual HbF (<1%) may be partially reactivated by chemical inducers and/or cytokines such as kit ligand (KL).MicroRNAs (miRs) play a pivotal role normal hematopoiesis: downmodulation of miR-221/222 stimulates erythropoietic proliferation through upmodulation receptor. Design and MethodsWe have explored possible kit/KL perinatal Hb switching evaluating: i) expression levels both...
Background Ovarian cancer remains a leading cause of death in women and development new therapies is essential. Second mitochondria derived activator caspase (SMAC) has been described to sensitize for apoptosis. We have explored the pro-apoptotic activity LBW242, mimic SMAC/DIABLO, on ovarian cell lines (A2780 cells its chemoresistant derivative A2780/ADR, SKOV3 HEY cells) primary cells. The effects LBW242 was determined by proliferation, apoptosis biochemical assays. Principal Findings...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been reported to exhibit therapeutic activity in cancer. However, many tumors remain resistant treatment with TRAIL. Therefore, small molecules that potentiate the cytotoxic effects of TRAIL could be used for combinatorial therapy. Here we found ionophore antibiotic salinomycin acts synergism TRAIL, enhancing TRAIL-induced apoptosis glioma cells. Treatment low doses combination augmented activation caspase-3 and increased...
Coagulation disorders are described in COVID-19 and long COVID patients. In particular, SARS-CoV-2 infection megakaryocytes, which precursors of platelets involved thrombotic events COVID-19, and, rare cases, vaccinated individuals, requires further investigation, particularly with the emergence new variants. CD147, regulation inflammation required to fight virus infection, can facilitate entry into megakaryocytes. MCT4, a co-binding protein CD147 key player glycolytic metabolism, could also...
We have investigated the expression of transferrin receptor (TfR) iron regulatory protein‐1 (IRP‐1) and protein‐2 (IRP‐2) in liquid suspension culture purified hematopoietic progenitor cells (HPCs) induced by a growth factor stimulus to proliferation unilineage differentiation/maturation through erythroid, granulocytic, monocytic megakaryocytic lineages. In initial HPC differentiation, TfR is both erythroid granulopoietic cultures. late differentiation (i.e. starting from day 5 culture) then...
High expression of the chemokine receptor 4, CXCR4, associated with a negative prognosis in acute myeloid leukemia, is related to hypoxia. Because CXCR4 under post-transcriptional control microRNA-146a normal and leukemic monocytic cells, we first investigated impact hypoxia on during monocytopoiesis leukemia. We then analyzed effects drug sensitivity CXCR4-expressing cells. found that target hypoxia-inducible factor-1α or -2α relation stage level hypoxia, demonstrated regulation...
Summary Previous studies suggested an important role for vascular endothelial growth factor (VEGF) and its receptors in postnatal haemopoiesis. However, it is unclear how VEGF receptor (VEGFR) signalling could interact with that issued from the activation of haematopoietic receptors. To elucidate this point we explored VEGF‐R2 granulocyte‐macrophage colony‐stimulating (GM‐CSFR) membrane localization cell TF1‐KDR cells (TF1 leukaemic overexpress VEGF‐R2/KDR). Activation either GM‐CSFR or was...
The tyrosine kinase Tie-2 and its ligands Angiopoietins (Angs) transduce critical signals for angiogenesis in endothelial cells. This receptor Ang-1 are coexpressed hematopoietic stem cells a subset of megakaryocytes, though possible role angiopoietins megakaryocytic differentiation/proliferation remains to be demonstrated. To investigate effect Ang-1/Ang-2 on proliferation/differentiation we have used both normal CD34+ induced differentiation the UT7 engineered express thrombopoietin (TPOR,...
Hematological malignancies refer to a heterogeneous group of neoplastic conditions lymphoid and hematopoietic tissues classified in leukemias, Hodgkin non-Hodgkin lymphomas multiple myeloma, according their presumed cell origin, genetic abnormalities, clinical features. Metabolic adaptation immune escape, which influence various cellular functions including proliferation survival hematological malignant tumor cells, are major aspects these that lead therapeutic drug resistance. Targeting...
Abstract We investigated the expression of Tie-2 in primary blasts from 111 patients with acute myeloid leukemia (AML) to evaluate a possible linkage between this receptor and immunophenotypic biologic properties leukemic blasts. was expressed at moderate high levels 39 23 AMLs, respectively. The analysis immunophenotype clearly showed that AML associated monocytic features. Interestingly, on concomitant other receptors for endothelial growth factors, such as vascular factor 1 (VEGF-R1),...